Drug Design, Development and Therapy

Drug Design, Development and Therapy is an international, peer-reviewed, open access journal that spans the spectrum of drug design, discovery and development through to clinical applications. The journal is characterized by the rapid reporting of high-quality original research, reviews, expert opinions, commentary and clinical studies in all therapeutic areas. Specific topics covered by the journal include: Drug target identification and validation Phenotypic screening and target deconvolution Biochemical analyses of drug targets and their pathways New methods or relevant applications in molecular/drug design and computer-aided drug discovery* Design, synthesis, and biological evaluation of novel biologically active compounds (including diagnostics or chemical probes) Structural or molecular biological studies elucidating molecular recognition processes Fragment-based drug discovery Pharmaceutical/red biotechnology Isolation, structural characterization, (bio)synthesis, bioengineering and pharmacological evaluation of natural products** Distribution, pharmacokinetics and metabolic transformations of drugs or biologically active compounds in drug development Drug delivery and formulation (design and characterization of dosage forms, release mechanisms and in vivo testing) Preclinical development studies Translational animal models Mechanisms of action and signalling pathways Toxicology Gene therapy, cell therapy and immunotherapy Personalized medicine and pharmacogenomics Clinical drug evaluation Patient safety and sustained use of medicines.

《Drug Design, Development and Therapy》是一本国际性、同行评审、开放获取的期刊，涵盖药物设计、发现和开发直至临床应用的各个领域。 该期刊的特点是快速报道所有治疗领域的高质量原创研究、评论、专家意见、评论和临床研究。 该期刊涵盖的具体主题包括： 药物靶标识别和验证 表型筛选和靶标反卷积 药物靶标及其途径的生化分析 分子/药物设计和计算机辅助药物发现的新方法或相关应用* 新型生物活性化合物的设计、合成和生物学评价（包括诊断或化学探针） 阐明分子识别过程的结构或分子生物学研究 基于片段的药物发现 制药/红色生物技术 天然产物的分离、结构表征、（生物）合成、生物工程和药理学评价** 药物开发中药物或生物活性化合物的分布、药代动力学和代谢转化 药物输送和配方（剂型的设计和表征、释放机制和体内测试） 临床前开发研究 转化动物模型 作用机制和信号通路 毒理学 基因治疗、细胞治疗和免疫治疗 个性化医疗和药物基因组学 临床药物评价 患者安全和持续用药。