套细胞淋巴瘤伴严重白细胞增多和骨髓浸润。

IF 0.6 4区医学 Q4 MEDICAL LABORATORY TECHNOLOGY

Clinical laboratory Pub Date : 2025-09-01 DOI:10.7754/Clin.Lab.2024.250251

Shanmei Lv, Hongkun Xv, Zhe Chen, Yi Feng

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引用次数: 0

摘要

背景：套细胞淋巴瘤（MCL）是一种以b细胞增生为特征的非霍奇金淋巴瘤亚型。严重的白细胞增多症是一种罕见的表现，可使MCL的诊断和治疗复杂化。方法：我们报告一例80岁男性MCL患者，其症状包括严重的白细胞增多症、淋巴结病和明显的骨髓浸润。诊断程序包括全血细胞计数、骨髓活检、淋巴结穿刺活检和流式细胞术来确认诊断。结果：患者白细胞计数超过491.28 × 109/L，外周血异常细胞占65.0%，骨髓分析显示成熟b细胞浸润超过90%。对于CyclinD1（+）套细胞淋巴瘤，考虑淋巴结活检的免疫组织化学结果。结论：该病例强调了在出现严重白细胞增多症的患者中，需要仔细鉴别MCL和其他淋巴细胞白血病。准确的识别对于适当的管理和治疗至关重要。

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Mantle Cell Lymphoma with Severe Hyperleukocytosis and Bone Marrow Infiltration.

Background: Mantle cell lymphoma (MCL) is a subtype of non-Hodgkin lymphoma characterized by the proliferation of B-cells. Severe hyperleukocytosis is an uncommon presentation that can complicate the diagnosis and management of MCL.

Methods: We present the case of an 80-year-old male patient suffering from MCL, who exhibited symptoms including severe hyperleukocytosis, lymphadenopathy, and significant bone marrow infiltration. Diagnostic procedures included complete blood count, bone marrow biopsy, lymph node needle biopsy, and flow cytometry to confirm the diagnosis.

Results: The patient exhibited a leukocyte count exceeding 491.28 x 109/L, 65.0% abnormal cell in peripheral blood, with bone marrow analysis revealing over 90% infiltration by mature B-cells. Immunohistochemical results of lymph node biopsy were considered for CyclinD1 (+) mantle cell lymphoma.

Conclusions: This case highlights the need for careful differential diagnosis between MCL and other lymphoblastic leukemias in patients presenting with severe hyperleukocytosis. Accurate identification is essential for appropriate management and treatment.

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来源期刊

Clinical laboratory 医学-医学实验技术

CiteScore

1.50

自引率

0.00%

发文量

494

审稿时长

3 months

期刊介绍： Clinical Laboratory is an international fully peer-reviewed journal covering all aspects of laboratory medicine and transfusion medicine. In addition to transfusion medicine topics Clinical Laboratory represents submissions concerning tissue transplantation and hematopoietic, cellular and gene therapies. The journal publishes original articles, review articles, posters, short reports, case studies and letters to the editor dealing with 1) the scientific background, implementation and diagnostic significance of laboratory methods employed in hospitals, blood banks and physicians'' offices and with 2) scientific, administrative and clinical aspects of transfusion medicine and 3) in addition to transfusion medicine topics Clinical Laboratory represents submissions concerning tissue transplantation and hematopoietic, cellular and gene therapies.