共轭神经紧张素-银纳米颗粒的制备及其对过敏性哮喘病理生理的影响。

IF 2.1 4区 医学 Q3 ALLERGY
Allergologia et immunopathologia Pub Date : 2025-09-01 eCollection Date: 2025-01-01 DOI:10.15586/aei.v53i5.1391
Yu Yang, Entezar Mehrabi Nasab, Seyyed Shamsadin Athari
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引用次数: 0

摘要

哮喘是一种呼吸道疾病,以炎症和气道阻塞为特征。炎症细胞在过敏性哮喘中起着重要作用,哮喘没有完全治愈的方法。医药领域的新方法之一是基于纳米粒子的治疗。本研究的目的是在纳米医学中引入一种新的神经紧张素治疗方法。制备了共轭肽纳米颗粒并对其进行了表征,并给药于哮喘小鼠。进行气道高反应性(AHR)试验、支气管肺泡灌洗液(BALF)细胞计数、细胞因子水平及组织病理学研究。肽纳米颗粒治疗可以控制AHR、BALF中嗜酸性粒细胞百分比、白细胞介素4 (IL-4)、IL-5和IL-33水平、气道周围和血管周围嗜酸性粒细胞炎症。新型肽纳米药物的研制和应用为控制变应性哮喘的病理相关机制开辟了新的治疗途径。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Fabrication and production of conjugated neurotensin-silver nanoparticles and evaluation of its effect on pathophysiology of allergic asthma.

Asthma, a respiratory tract disease, is characterized by inflammation and obstruction of airway. Inflammatory cells play a significant role in allergic asthma, and there is no complete cure for asthma. One of the new approaches in medicines is nanoparticle-base treatment. The aim of the current study is to introduce a new therapeutic approach in nano-medicine with neurotensin. Conjugated peptide nanoparticles were prepared and characterized, and then administrated to asthmatic mice. Airway hyperresponsiveness (AHR) test, broncho-alveolar lavage fluid (BALF) cells counting, cytokines level, and histopathology study were conducted. Treatment with peptide nanoparticles could control AHR, percentage of eosinophils in BALF, levels of interleukin 4 (IL-4), IL-5, and IL-33, peri-airways and perivascular eosinophilic inflammation. Producing and using of new peptide nano-drugs could introduce new therapeutic approach in controlling pathological-related mechanisms in allergic asthma.

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来源期刊
CiteScore
3.70
自引率
0.00%
发文量
131
审稿时长
6-12 weeks
期刊介绍: Founded in 1972 by Professor A. Oehling, Allergologia et Immunopathologia is a forum for those working in the field of pediatric asthma, allergy and immunology. Manuscripts related to clinical, epidemiological and experimental allergy and immunopathology related to childhood will be considered for publication. Allergologia et Immunopathologia is the official journal of the Spanish Society of Pediatric Allergy and Clinical Immunology (SEICAP) and also of the Latin American Society of Immunodeficiencies (LASID). It has and independent international Editorial Committee which submits received papers for peer-reviewing by international experts. The journal accepts original and review articles from all over the world, together with consensus statements from the aforementioned societies. Occasionally, the opinion of an expert on a burning topic is published in the "Point of View" section. Letters to the Editor on previously published papers are welcomed. Allergologia et Immunopathologia publishes 6 issues per year and is included in the major databases such as Pubmed, Scopus, Web of Knowledge, etc.
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