标题刺凤蝶新翅色素。

IF 2.5 4区医学 Q3 CHEMISTRY, MEDICINAL

Journal of Natural Medicines Pub Date : 2025-09-08 DOI:10.1007/s11418-025-01945-z

Liang Shen, Wenhao Mu, Peixin Wang, Maoni Ren, Yating Jia, Xiaoran Min, Jiajia He, Guozheng Huang, Hui Shen, Jianguo Cao

{"title":"标题刺凤蝶新翅色素。","authors":"Liang Shen, Wenhao Mu, Peixin Wang, Maoni Ren, Yating Jia, Xiaoran Min, Jiajia He, Guozheng Huang, Hui Shen, Jianguo Cao","doi":"10.1007/s11418-025-01945-z","DOIUrl":null,"url":null,"abstract":"Two new (1-2) and eight known pterosins (3-10) were obtained from the aerial parts of Hypolepis punctata. One compound (11) was synthesized from compound 4. Their structures were established by spectroscopic methods and the absolute configuration was further determined by single-crystal X-ray diffraction analysis for compounds 1, 3 and 4. Notably, compound 1 showed low toxicity while significantly inhibiting lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW264.7 cells.","PeriodicalId":654,"journal":{"name":"Journal of Natural Medicines","volume":" ","pages":""},"PeriodicalIF":2.5000,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"New pterosins from Hypolepis punctata.\",\"authors\":\"Liang Shen, Wenhao Mu, Peixin Wang, Maoni Ren, Yating Jia, Xiaoran Min, Jiajia He, Guozheng Huang, Hui Shen, Jianguo Cao\",\"doi\":\"10.1007/s11418-025-01945-z\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Two new (1-2) and eight known pterosins (3-10) were obtained from the aerial parts of Hypolepis punctata. One compound (11) was synthesized from compound 4. Their structures were established by spectroscopic methods and the absolute configuration was further determined by single-crystal X-ray diffraction analysis for compounds 1, 3 and 4. Notably, compound 1 showed low toxicity while significantly inhibiting lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW264.7 cells.\",\"PeriodicalId\":654,\"journal\":{\"name\":\"Journal of Natural Medicines\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":2.5000,\"publicationDate\":\"2025-09-08\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Natural Medicines\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/s11418-025-01945-z\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, MEDICINAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Natural Medicines","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s11418-025-01945-z","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}

引用次数: 0

摘要

从斑点鱼的地上部分获得了2个新的（1-2）和8个已知的（3-10）翼红素。由化合物4合成一个化合物（11）。通过光谱方法确定了它们的结构，并通过单晶x射线衍射分析进一步确定了化合物1、3和4的绝对构型。值得注意的是，化合物1在RAW264.7细胞中显示出低毒性，同时显著抑制脂多糖（LPS）诱导的一氧化氮（NO）的产生。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

New pterosins from Hypolepis punctata.

Two new (1-2) and eight known pterosins (3-10) were obtained from the aerial parts of Hypolepis punctata. One compound (11) was synthesized from compound 4. Their structures were established by spectroscopic methods and the absolute configuration was further determined by single-crystal X-ray diffraction analysis for compounds 1, 3 and 4. Notably, compound 1 showed low toxicity while significantly inhibiting lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW264.7 cells.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Journal of Natural Medicines 医学-药学

CiteScore

6.90

自引率

3.00%

发文量

审稿时长

1.7 months

期刊介绍： The Journal of Natural Medicines is an international journal publishing original research in naturally occurring medicines and their related foods and cosmetics. It covers: -chemistry of natural products -biochemistry of medicinal plants -pharmacology of natural products and herbs, including Kampo formulas and traditional herbs -botanical anatomy -cultivation of medicinal plants. The journal accepts Original Papers, Notes, Rapid Communications and Natural Resource Letters. Reviews and Mini-Reviews are generally invited.