Sungjoo Lee, Min Young Chun, Hyemin Jang, Michael Weiner, Suzanne E. Schindler, Daeun Shin, Heekyung Kang, Sohyun Yim, Eun Hye Lee, Kyunga Kim, Hee Jin Kim, Duk L. Na, Jun Pyo Kim, Sang Won Seo, the ADNI, A4, and K-ROAD studies
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Subgroup analyses examined apolipoprotein E (<i>APOE</i>) ε4 and sex effects.</p>\n </section>\n \n <section>\n \n <h3> RESULTS</h3>\n \n <p>Age-related centile curves of Aβ PET Centiloid values showed stable distributions in the lower percentiles, increasing with age in the upper percentiles. NHWs exhibited steeper Aβ accumulation trajectories, particularly among <i>APOE</i> ε4 carriers. Calibration with longitudinal data confirmed the reliability of this cross-sectional method.</p>\n </section>\n \n <section>\n \n <h3> DISCUSSION</h3>\n \n <p>We developed a statistical model of age-related Aβ PET trajectories using baseline data, validated with longitudinal data. NHWs exhibited steeper trajectories than Koreans, suggesting population-specific differences in Aβ accumulation.</p>\n </section>\n \n <section>\n \n <h3> Highlights</h3>\n \n <div>\n <ul>\n \n <li>A generalized additive model for location, scale, and shape model was applied to examine age-related amyloid beta (Aβ) trajectories with baseline data.</li>\n \n <li>Trajectories were validated using longitudinal data, confirming model reliability.</li>\n \n <li>Non-Hispanic Whites exhibited steeper trajectories than Koreans, especially in apolipoprotein E ε4 carriers.</li>\n \n <li>Our approach enables scalable modeling of Aβ dynamics for Alzheimer's disease prevention strategies.</li>\n \n <li>Findings highlight the importance of multi-ethnic research in Aβ accumulation.</li>\n </ul>\n </div>\n </section>\n </div>","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"21 9","pages":""},"PeriodicalIF":11.1000,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://alz-journals.onlinelibrary.wiley.com/doi/epdf/10.1002/alz.70675","citationCount":"0","resultStr":"{\"title\":\"Age-related amyloid beta dynamics modeled with the generalized additive model for location, scale, and shape (GAMLSS) across diverse populations: Cross-sectional trajectories and longitudinal validation\",\"authors\":\"Sungjoo Lee, Min Young Chun, Hyemin Jang, Michael Weiner, Suzanne E. Schindler, Daeun Shin, Heekyung Kang, Sohyun Yim, Eun Hye Lee, Kyunga Kim, Hee Jin Kim, Duk L. Na, Jun Pyo Kim, Sang Won Seo, the ADNI, A4, and K-ROAD studies\",\"doi\":\"10.1002/alz.70675\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> INTRODUCTION</h3>\\n \\n <p>We developed and validated age-related amyloid beta (Aβ) positron emission tomography (PET) trajectories using a statistical model in cognitively unimpaired (CU) individuals.</p>\\n </section>\\n \\n <section>\\n \\n <h3> METHODS</h3>\\n \\n <p>We analyzed 849 CU Korean and 521 CU non-Hispanic White (NHW) participants after propensity score matching. Aβ PET trajectories were modeled using the generalized additive model for location, scale, and shape (GAMLSS) based on baseline data and validated with longitudinal data. 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Age-related amyloid beta dynamics modeled with the generalized additive model for location, scale, and shape (GAMLSS) across diverse populations: Cross-sectional trajectories and longitudinal validation
INTRODUCTION
We developed and validated age-related amyloid beta (Aβ) positron emission tomography (PET) trajectories using a statistical model in cognitively unimpaired (CU) individuals.
METHODS
We analyzed 849 CU Korean and 521 CU non-Hispanic White (NHW) participants after propensity score matching. Aβ PET trajectories were modeled using the generalized additive model for location, scale, and shape (GAMLSS) based on baseline data and validated with longitudinal data. Subgroup analyses examined apolipoprotein E (APOE) ε4 and sex effects.
RESULTS
Age-related centile curves of Aβ PET Centiloid values showed stable distributions in the lower percentiles, increasing with age in the upper percentiles. NHWs exhibited steeper Aβ accumulation trajectories, particularly among APOE ε4 carriers. Calibration with longitudinal data confirmed the reliability of this cross-sectional method.
DISCUSSION
We developed a statistical model of age-related Aβ PET trajectories using baseline data, validated with longitudinal data. NHWs exhibited steeper trajectories than Koreans, suggesting population-specific differences in Aβ accumulation.
Highlights
A generalized additive model for location, scale, and shape model was applied to examine age-related amyloid beta (Aβ) trajectories with baseline data.
Trajectories were validated using longitudinal data, confirming model reliability.
Non-Hispanic Whites exhibited steeper trajectories than Koreans, especially in apolipoprotein E ε4 carriers.
Our approach enables scalable modeling of Aβ dynamics for Alzheimer's disease prevention strategies.
Findings highlight the importance of multi-ethnic research in Aβ accumulation.
期刊介绍：
Alzheimer's & Dementia is a peer-reviewed journal that aims to bridge knowledge gaps in dementia research by covering the entire spectrum, from basic science to clinical trials to social and behavioral investigations. It provides a platform for rapid communication of new findings and ideas, optimal translation of research into practical applications, increasing knowledge across diverse disciplines for early detection, diagnosis, and intervention, and identifying promising new research directions. In July 2008, Alzheimer's & Dementia was accepted for indexing by MEDLINE, recognizing its scientific merit and contribution to Alzheimer's research.
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