Dang Thi Ngoc Hoa, Nguyen Duc Hong, Pham Thang Long, Bui Le Thanh Nhan, Nguyen Ngoc Nam and Do Mai Nguyen
{"title":"利用还原氧化石墨烯修饰电极对氨苄西林进行绿色电化学传感","authors":"Dang Thi Ngoc Hoa, Nguyen Duc Hong, Pham Thang Long, Bui Le Thanh Nhan, Nguyen Ngoc Nam and Do Mai Nguyen","doi":"10.1039/D5LF00127G","DOIUrl":null,"url":null,"abstract":"<p >A “green” electrochemical sensor for the detection of ampicillin (AMP) was developed using a reduced graphene oxide-modified glassy carbon electrode (rGO/GCE). The sensor exhibited good performance with a linear detection range from 0.02 μM to 2.56 μM and a low detection limit of 6.75 nM. Characterization of the rGO material was carried out using Fourier-transform infrared (FT-IR) and Raman spectroscopy, confirming the successful reduction of graphene oxide and the restoration of electrical conductivity. The rGO/GCE sensor demonstrated high selectivity, minimal interference from common compounds, and good repeatability, reproducibility and long-term stability. Real-sample analysis in spiked urine achieved recovery rates of 97–103%, validated by high-performance liquid chromatography (HPLC). The results highlight the rGO/GCE sensor as a sensitive, reliable, and cost-effective platform for AMP monitoring in pharmaceutical applications.</p>","PeriodicalId":101138,"journal":{"name":"RSC Applied Interfaces","volume":" 5","pages":" 1209-1219"},"PeriodicalIF":0.0000,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/lf/d5lf00127g?page=search","citationCount":"0","resultStr":"{\"title\":\"Green electrochemical sensing of ampicillin using reduced graphene oxide-modified electrodes\",\"authors\":\"Dang Thi Ngoc Hoa, Nguyen Duc Hong, Pham Thang Long, Bui Le Thanh Nhan, Nguyen Ngoc Nam and Do Mai Nguyen\",\"doi\":\"10.1039/D5LF00127G\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p >A “green” electrochemical sensor for the detection of ampicillin (AMP) was developed using a reduced graphene oxide-modified glassy carbon electrode (rGO/GCE). The sensor exhibited good performance with a linear detection range from 0.02 μM to 2.56 μM and a low detection limit of 6.75 nM. Characterization of the rGO material was carried out using Fourier-transform infrared (FT-IR) and Raman spectroscopy, confirming the successful reduction of graphene oxide and the restoration of electrical conductivity. The rGO/GCE sensor demonstrated high selectivity, minimal interference from common compounds, and good repeatability, reproducibility and long-term stability. Real-sample analysis in spiked urine achieved recovery rates of 97–103%, validated by high-performance liquid chromatography (HPLC). The results highlight the rGO/GCE sensor as a sensitive, reliable, and cost-effective platform for AMP monitoring in pharmaceutical applications.</p>\",\"PeriodicalId\":101138,\"journal\":{\"name\":\"RSC Applied Interfaces\",\"volume\":\" 5\",\"pages\":\" 1209-1219\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-05-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://pubs.rsc.org/en/content/articlepdf/2025/lf/d5lf00127g?page=search\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"RSC Applied Interfaces\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://pubs.rsc.org/en/content/articlelanding/2025/lf/d5lf00127g\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"RSC Applied Interfaces","FirstCategoryId":"1085","ListUrlMain":"https://pubs.rsc.org/en/content/articlelanding/2025/lf/d5lf00127g","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Green electrochemical sensing of ampicillin using reduced graphene oxide-modified electrodes
A “green” electrochemical sensor for the detection of ampicillin (AMP) was developed using a reduced graphene oxide-modified glassy carbon electrode (rGO/GCE). The sensor exhibited good performance with a linear detection range from 0.02 μM to 2.56 μM and a low detection limit of 6.75 nM. Characterization of the rGO material was carried out using Fourier-transform infrared (FT-IR) and Raman spectroscopy, confirming the successful reduction of graphene oxide and the restoration of electrical conductivity. The rGO/GCE sensor demonstrated high selectivity, minimal interference from common compounds, and good repeatability, reproducibility and long-term stability. Real-sample analysis in spiked urine achieved recovery rates of 97–103%, validated by high-performance liquid chromatography (HPLC). The results highlight the rGO/GCE sensor as a sensitive, reliable, and cost-effective platform for AMP monitoring in pharmaceutical applications.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
