口腔潜在恶性疾病和口腔癌中Wnt和Notch信号通路的科学计量学研究

IF 3.1 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Dental Sciences Pub Date : 2025-06-27 DOI:10.1016/j.jds.2025.06.015

Xiaoliang Luo , Yiwen Deng , Hao Wu

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引用次数: 0

摘要

背景/目的越来越多的证据表明，某些细胞信号通路的异常激活在口腔癌的发生和发展过程中发生。本研究的目的是分析口腔潜在恶性疾病（OPMD）和口腔鳞状细胞癌（OSCC）中Wnt和Notch通路的科学计量学特征。材料与方法综合检索Scopus数据库中所有关于OPMD/OSCC中Wnt和Notch通路的论文。结果共检索到OPMD/OSCC领域有关Wnt和Notch信号通路的论文301篇和169篇。对于OPMD/OSCC研究中的Wnt通路，有特色的关键词包括典型Wnt信号、β-catenin、CTNNB1蛋白、cyclin D1、卷曲蛋白、Myc、Bcl-2、转录因子、DNA甲基化、长链非编码RNA、microRNA。Notch通路在生物研究方面的特色关键词有肿瘤干细胞、血管生成、遗传关联、癌基因、Jagged1等。代谢、遗传学、信号转导、凋亡、细胞增殖、癌变、肿瘤标志物、上皮间质转化、蛋白质功能、药物筛选、基因突变等生物研究方面的常用关键词相同。结论本研究首次阐明了所有关于Wnt和Notch通路在OPMD/OSCC中的科学计量学特征，为研究人员深入研究Wnt和Notch相关OPMD/OSCC的机制并转化为临床研究提供了新的思路。

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A scientometric study on Wnt and Notch signaling pathways in oral potentially malignant disorders and oral cancer

Background/purpose

Accumulating evidence indicates that aberrant activation of certain cellular signaling pathways occurs during the development and progression of oral cancer. The purpose of this study was to analyze the scientometric characteristics of Wnt and Notch pathways in oral potentially malignant disorders (OPMD) and oral squamous cell carcinoma (OSCC).

Materials and methods

All the papers on Wnt and Notch pathways in OPMD/OSCC were comprehensively retrieved from the Scopus database.

Results

A total of 301 and 169 papers on Wnt and Notch signaling pathway in the field of OPMD/OSCC were retrieved, respectively. As for Wnt pathway in OPMD/OSCC research, distinctive keywords included canonical Wnt signaling, β-catenin, CTNNB1 protein, cyclin D1, frizzled protein, Myc, Bcl-2, transcription factor, DNA methylation, long noncoding RNA, and microRNA. As for Notch pathway, distinctive keywords of bioresearch aspect included cancer stem cell, angiogenesis, genetic association, oncogene, and Jagged1. There were the same common keywords of bioresearch aspect, such as metabolism, genetics, signal transduction, apoptosis, cell proliferation, carcinogenesis, tumor marker, epithelial mesenchymal transition, protein function, drug screening, and gene mutation.

Conclusion

This study for the first time elucidated the scientometric characteristics of all the publications on Wnt and Notch pathways in OPMD/OSCC, and would provide new insights for researchers to delve into the mechanisms of Wnt and Notch related OPMD/OSCC and translate into clinical studies.

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来源期刊

Journal of Dental Sciences 医学-牙科与口腔外科

CiteScore

5.10

自引率

14.30%

发文量

348

审稿时长

6 days

期刊介绍： he Journal of Dental Sciences (JDS), published quarterly, is the official and open access publication of the Association for Dental Sciences of the Republic of China (ADS-ROC). The precedent journal of the JDS is the Chinese Dental Journal (CDJ) which had already been covered by MEDLINE in 1988. As the CDJ continued to prove its importance in the region, the ADS-ROC decided to move to the international community by publishing an English journal. Hence, the birth of the JDS in 2006. The JDS is indexed in the SCI Expanded since 2008. It is also indexed in Scopus, and EMCare, ScienceDirect, SIIC Data Bases. The topics covered by the JDS include all fields of basic and clinical dentistry. Some manuscripts focusing on the study of certain endemic diseases such as dental caries and periodontal diseases in particular regions of any country as well as oral pre-cancers, oral cancers, and oral submucous fibrosis related to betel nut chewing habit are also considered for publication. Besides, the JDS also publishes articles about the efficacy of a new treatment modality on oral verrucous hyperplasia or early oral squamous cell carcinoma.