伴有巨噬细胞增多的口腔扁平苔藓患者的贫血、血凝素缺乏、高同型半胱氨酸血症和血清胃壁细胞抗体阳性

IF 3.1 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Dental Sciences Pub Date : 2025-07-10 DOI:10.1016/j.jds.2025.06.023

Julia Yu-Fong Chang , Yu-Hsueh Wu , Yi-Pang Lee , Yi-Ping Wang , Andy Sun , Chun-Pin Chiang

{"title":"伴有巨噬细胞增多的口腔扁平苔藓患者的贫血、血凝素缺乏、高同型半胱氨酸血症和血清胃壁细胞抗体阳性","authors":"Julia Yu-Fong Chang , Yu-Hsueh Wu , Yi-Pang Lee , Yi-Ping Wang , Andy Sun , Chun-Pin Chiang","doi":"10.1016/j.jds.2025.06.023","DOIUrl":null,"url":null,"abstract":"<div><h3>Background/purpose</h3><div>Macrocytosis is defined as having the mean corpuscular volume (MCV) ≥ 100 fL. This study evaluated whether 36 oral lichen planus (OLP) patients with macrocytosis (macrocytosis/OLP patients) had significantly higher frequencies of anemia, hematinic deficiencies, hyperhomocysteinemia, and serum gastric parietal cell antibody (GPCA) positivity than 588 healthy control subjects or 588 OLP patients.</div></div><div><h3>Materials and methods</h3><div>Complete blood count, serum iron, vitamin B12, folic acid, homocysteine, and GPCA levels in 36 macrocytosis/OLP patients, 588 OLP patients, and 588 healthy control subjects were measured and compared.</div></div><div><h3>Results</h3><div>We found that 66.7 %, 8.3 %, 91.7 %, 0.0 %, 94.4 %, and 80.6 % of 36 macrocytosis/OLP patients were diagnosed as having blood hemoglobin and serum iron, vitamin B12, and folic acid deficiencies, hyperhomocysteinemia, and serum GPCA positivity, respectively. Moreover, 36 macrocytosis/OLP patients had significantly higher frequencies of blood hemoglobin and serum vitamin B12 deficiencies, hyperhomocysteinemia, and serum GPCA positivity than 588 healthy control subjects or 588 OLP patients (all <em>P</em>-values <0.001). In addition, 36 macrocytosis/OLP patients also had a significantly higher frequency of serum iron deficiency than 588 healthy control subjects (<em>P</em> < 0.001). Pernicious anemia was found in 17 macrocytosis/OLP patients.</div></div><div><h3>Conclusion</h3><div>There are significantly higher frequencies of anemia and serum iron and vitamin B12 deficiencies, hyperhomocysteinemia, and serum GPCA positivity in 36 macrocytosis/OLP patients than in 588 healthy control subjects. Moreover, 36 macrocytosis/OLP patients also have significantly higher frequencies of anemia, serum vitamin B12 deficiency, hyperhomocysteinemia, and serum GPCA positivity than 588 OLP patients.</div></div>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"20 4","pages":"Pages 2204-2210"},"PeriodicalIF":3.1000,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Anemia, hematinic deficiencies, hyperhomocysteinemia, and serum gastric parietal cell antibody positivity in oral lichen planus patients with macrocytosis\",\"authors\":\"Julia Yu-Fong Chang , Yu-Hsueh Wu , Yi-Pang Lee , Yi-Ping Wang , Andy Sun , Chun-Pin Chiang\",\"doi\":\"10.1016/j.jds.2025.06.023\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background/purpose</h3><div>Macrocytosis is defined as having the mean corpuscular volume (MCV) ≥ 100 fL. This study evaluated whether 36 oral lichen planus (OLP) patients with macrocytosis (macrocytosis/OLP patients) had significantly higher frequencies of anemia, hematinic deficiencies, hyperhomocysteinemia, and serum gastric parietal cell antibody (GPCA) positivity than 588 healthy control subjects or 588 OLP patients.</div></div><div><h3>Materials and methods</h3><div>Complete blood count, serum iron, vitamin B12, folic acid, homocysteine, and GPCA levels in 36 macrocytosis/OLP patients, 588 OLP patients, and 588 healthy control subjects were measured and compared.</div></div><div><h3>Results</h3><div>We found that 66.7 %, 8.3 %, 91.7 %, 0.0 %, 94.4 %, and 80.6 % of 36 macrocytosis/OLP patients were diagnosed as having blood hemoglobin and serum iron, vitamin B12, and folic acid deficiencies, hyperhomocysteinemia, and serum GPCA positivity, respectively. Moreover, 36 macrocytosis/OLP patients had significantly higher frequencies of blood hemoglobin and serum vitamin B12 deficiencies, hyperhomocysteinemia, and serum GPCA positivity than 588 healthy control subjects or 588 OLP patients (all <em>P</em>-values <0.001). In addition, 36 macrocytosis/OLP patients also had a significantly higher frequency of serum iron deficiency than 588 healthy control subjects (<em>P</em> < 0.001). Pernicious anemia was found in 17 macrocytosis/OLP patients.</div></div><div><h3>Conclusion</h3><div>There are significantly higher frequencies of anemia and serum iron and vitamin B12 deficiencies, hyperhomocysteinemia, and serum GPCA positivity in 36 macrocytosis/OLP patients than in 588 healthy control subjects. Moreover, 36 macrocytosis/OLP patients also have significantly higher frequencies of anemia, serum vitamin B12 deficiency, hyperhomocysteinemia, and serum GPCA positivity than 588 OLP patients.</div></div>\",\"PeriodicalId\":15583,\"journal\":{\"name\":\"Journal of Dental Sciences\",\"volume\":\"20 4\",\"pages\":\"Pages 2204-2210\"},\"PeriodicalIF\":3.1000,\"publicationDate\":\"2025-07-10\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Dental Sciences\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1991790225002351\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"DENTISTRY, ORAL SURGERY & MEDICINE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Dental Sciences","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1991790225002351","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"DENTISTRY, ORAL SURGERY & MEDICINE","Score":null,"Total":0}

引用次数: 0

摘要

背景/目的巨噬细胞增多症被定义为平均红细胞体积(MCV)≥100 fL。本研究评估了36例伴有巨噬细胞增多症的口腔扁平苔藓（OLP）患者（巨噬细胞增多症/OLP患者）的贫血、血液学缺陷、高同型半胱氨酸血症和血清胃壁细胞抗体（GPCA）阳性的频率是否明显高于588名健康对照者或588名OLP患者。材料与方法测定36例巨噬细胞增多/OLP患者、588例OLP患者和588例健康对照者的全血细胞计数、血清铁、维生素B12、叶酸、同型半胱氨酸和GPCA水平并进行比较。结果36例巨噬细胞增多症/OLP患者中分别有66.7%、8.3%、91.7%、0.0%、94.4%和80.6%诊断为血红蛋白和血清铁、维生素B12和叶酸缺乏、高同型半胱氨酸血症和血清GPCA阳性。此外，36例巨噬细胞增多症/OLP患者的血红蛋白和血清维生素B12缺乏症、高同型半胱氨酸血症和血清GPCA阳性的频率显著高于588例健康对照者或588例OLP患者（p值均为0.001）。此外，36例巨噬细胞增多症/OLP患者血清铁缺乏的频率也显著高于588例健康对照（P < 0.001）。巨噬细胞增多症/OLP患者有恶性贫血17例。结论36例巨噬细胞增多症/OLP患者的贫血、血清铁和维生素B12缺乏、高同型半胱氨酸血症和血清GPCA阳性发生率明显高于588例健康对照者。此外，36例巨噬细胞增多症/OLP患者的贫血、血清维生素B12缺乏症、高同型半胱氨酸血症和血清GPCA阳性的频率也明显高于588例OLP患者。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Anemia, hematinic deficiencies, hyperhomocysteinemia, and serum gastric parietal cell antibody positivity in oral lichen planus patients with macrocytosis

Background/purpose

Macrocytosis is defined as having the mean corpuscular volume (MCV) ≥ 100 fL. This study evaluated whether 36 oral lichen planus (OLP) patients with macrocytosis (macrocytosis/OLP patients) had significantly higher frequencies of anemia, hematinic deficiencies, hyperhomocysteinemia, and serum gastric parietal cell antibody (GPCA) positivity than 588 healthy control subjects or 588 OLP patients.

Materials and methods

Complete blood count, serum iron, vitamin B12, folic acid, homocysteine, and GPCA levels in 36 macrocytosis/OLP patients, 588 OLP patients, and 588 healthy control subjects were measured and compared.

Results

We found that 66.7 %, 8.3 %, 91.7 %, 0.0 %, 94.4 %, and 80.6 % of 36 macrocytosis/OLP patients were diagnosed as having blood hemoglobin and serum iron, vitamin B12, and folic acid deficiencies, hyperhomocysteinemia, and serum GPCA positivity, respectively. Moreover, 36 macrocytosis/OLP patients had significantly higher frequencies of blood hemoglobin and serum vitamin B12 deficiencies, hyperhomocysteinemia, and serum GPCA positivity than 588 healthy control subjects or 588 OLP patients (all P-values <0.001). In addition, 36 macrocytosis/OLP patients also had a significantly higher frequency of serum iron deficiency than 588 healthy control subjects (P < 0.001). Pernicious anemia was found in 17 macrocytosis/OLP patients.

Conclusion

There are significantly higher frequencies of anemia and serum iron and vitamin B12 deficiencies, hyperhomocysteinemia, and serum GPCA positivity in 36 macrocytosis/OLP patients than in 588 healthy control subjects. Moreover, 36 macrocytosis/OLP patients also have significantly higher frequencies of anemia, serum vitamin B12 deficiency, hyperhomocysteinemia, and serum GPCA positivity than 588 OLP patients.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Journal of Dental Sciences 医学-牙科与口腔外科

CiteScore

5.10

自引率

14.30%

发文量

348

审稿时长

6 days

期刊介绍： he Journal of Dental Sciences (JDS), published quarterly, is the official and open access publication of the Association for Dental Sciences of the Republic of China (ADS-ROC). The precedent journal of the JDS is the Chinese Dental Journal (CDJ) which had already been covered by MEDLINE in 1988. As the CDJ continued to prove its importance in the region, the ADS-ROC decided to move to the international community by publishing an English journal. Hence, the birth of the JDS in 2006. The JDS is indexed in the SCI Expanded since 2008. It is also indexed in Scopus, and EMCare, ScienceDirect, SIIC Data Bases. The topics covered by the JDS include all fields of basic and clinical dentistry. Some manuscripts focusing on the study of certain endemic diseases such as dental caries and periodontal diseases in particular regions of any country as well as oral pre-cancers, oral cancers, and oral submucous fibrosis related to betel nut chewing habit are also considered for publication. Besides, the JDS also publishes articles about the efficacy of a new treatment modality on oral verrucous hyperplasia or early oral squamous cell carcinoma.