Shengxiang Liang , Li Huang , Jingfang Zhu , Miaoran Lin , Minguang Yang , Jiahui Gao , Chuyi Ma , Xiaolong Yin , Junchao Yang , Lei Yang , Weilin Liu , Jing Tao , Lidian Chen
{"title":"健忘轻度认知障碍患者海马分区域网络异常与情景记忆衰退相关","authors":"Shengxiang Liang , Li Huang , Jingfang Zhu , Miaoran Lin , Minguang Yang , Jiahui Gao , Chuyi Ma , Xiaolong Yin , Junchao Yang , Lei Yang , Weilin Liu , Jing Tao , Lidian Chen","doi":"10.1016/j.ajp.2025.104683","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>Amnestic mild cognitive impairment (aMCI) is characterized by marked episodic memory decline. The hippocampus is essential for episodic memory, and integration of information within its subregions is central to this process. This study examined how alterations in hippocampal subregional network relate to episodic memory impairment in aMCI.</div></div><div><h3>Methods</h3><div>Participants with aMCI (n = 32) were recruited between March 2021 and May 2022, with cognitively normal controls (n = 32) matched for age, sex, and years of education. Episodic memory was evaluated using the Logical Memory subtest of the Wechsler Memory Scale–Revised. Resting-state functional MRI data were acquired. Hippocampal subregional networks were constructed to characterize functional connectivity and topological alterations in aMCI. Pearson correlation analyses were used to assess the relationships between network metrics and episodic memory function.</div></div><div><h3>Results</h3><div>We found impaired integration of the hippocampal subregion network in aMCI, as reflected by increased path length and decreased global efficiency (p < 0.05). Longer path length correlated with lower Logical Memory scores. Functional connectivity decreased between the bilateral parasubiculum and the left granule and molecular layer of the dentate gyrus and between the right parasubiculum and left CA1 (connection-level threshold p < 0.001, network-level threshold pFDR < 0.05). Nodal analyses revealed reduced degree centrality and nodal efficiency in the bilateral parasubiculum and presubiculum (pFDR < 0.05), both positively associated with episodic memory in aMCI (pFDR < 0.05).</div></div><div><h3>Conclusions</h3><div>These findings suggest that episodic memory impairment in aMCI is linked to altered hippocampal subregional integration, with the parasubiculum and presubiculum as potential key regions.</div></div>","PeriodicalId":8543,"journal":{"name":"Asian journal of psychiatry","volume":"112 ","pages":"Article 104683"},"PeriodicalIF":4.5000,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Aberrant hippocampal subregional network associated with episodic memory decline in amnestic mild cognitive impairment\",\"authors\":\"Shengxiang Liang , Li Huang , Jingfang Zhu , Miaoran Lin , Minguang Yang , Jiahui Gao , Chuyi Ma , Xiaolong Yin , Junchao Yang , Lei Yang , Weilin Liu , Jing Tao , Lidian Chen\",\"doi\":\"10.1016/j.ajp.2025.104683\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><div>Amnestic mild cognitive impairment (aMCI) is characterized by marked episodic memory decline. The hippocampus is essential for episodic memory, and integration of information within its subregions is central to this process. This study examined how alterations in hippocampal subregional network relate to episodic memory impairment in aMCI.</div></div><div><h3>Methods</h3><div>Participants with aMCI (n = 32) were recruited between March 2021 and May 2022, with cognitively normal controls (n = 32) matched for age, sex, and years of education. Episodic memory was evaluated using the Logical Memory subtest of the Wechsler Memory Scale–Revised. Resting-state functional MRI data were acquired. Hippocampal subregional networks were constructed to characterize functional connectivity and topological alterations in aMCI. Pearson correlation analyses were used to assess the relationships between network metrics and episodic memory function.</div></div><div><h3>Results</h3><div>We found impaired integration of the hippocampal subregion network in aMCI, as reflected by increased path length and decreased global efficiency (p < 0.05). Longer path length correlated with lower Logical Memory scores. Functional connectivity decreased between the bilateral parasubiculum and the left granule and molecular layer of the dentate gyrus and between the right parasubiculum and left CA1 (connection-level threshold p < 0.001, network-level threshold pFDR < 0.05). Nodal analyses revealed reduced degree centrality and nodal efficiency in the bilateral parasubiculum and presubiculum (pFDR < 0.05), both positively associated with episodic memory in aMCI (pFDR < 0.05).</div></div><div><h3>Conclusions</h3><div>These findings suggest that episodic memory impairment in aMCI is linked to altered hippocampal subregional integration, with the parasubiculum and presubiculum as potential key regions.</div></div>\",\"PeriodicalId\":8543,\"journal\":{\"name\":\"Asian journal of psychiatry\",\"volume\":\"112 \",\"pages\":\"Article 104683\"},\"PeriodicalIF\":4.5000,\"publicationDate\":\"2025-09-05\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Asian journal of psychiatry\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1876201825003260\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"PSYCHIATRY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Asian journal of psychiatry","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1876201825003260","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PSYCHIATRY","Score":null,"Total":0}
Aberrant hippocampal subregional network associated with episodic memory decline in amnestic mild cognitive impairment
Background
Amnestic mild cognitive impairment (aMCI) is characterized by marked episodic memory decline. The hippocampus is essential for episodic memory, and integration of information within its subregions is central to this process. This study examined how alterations in hippocampal subregional network relate to episodic memory impairment in aMCI.
Methods
Participants with aMCI (n = 32) were recruited between March 2021 and May 2022, with cognitively normal controls (n = 32) matched for age, sex, and years of education. Episodic memory was evaluated using the Logical Memory subtest of the Wechsler Memory Scale–Revised. Resting-state functional MRI data were acquired. Hippocampal subregional networks were constructed to characterize functional connectivity and topological alterations in aMCI. Pearson correlation analyses were used to assess the relationships between network metrics and episodic memory function.
Results
We found impaired integration of the hippocampal subregion network in aMCI, as reflected by increased path length and decreased global efficiency (p < 0.05). Longer path length correlated with lower Logical Memory scores. Functional connectivity decreased between the bilateral parasubiculum and the left granule and molecular layer of the dentate gyrus and between the right parasubiculum and left CA1 (connection-level threshold p < 0.001, network-level threshold pFDR < 0.05). Nodal analyses revealed reduced degree centrality and nodal efficiency in the bilateral parasubiculum and presubiculum (pFDR < 0.05), both positively associated with episodic memory in aMCI (pFDR < 0.05).
Conclusions
These findings suggest that episodic memory impairment in aMCI is linked to altered hippocampal subregional integration, with the parasubiculum and presubiculum as potential key regions.
期刊介绍:
The Asian Journal of Psychiatry serves as a comprehensive resource for psychiatrists, mental health clinicians, neurologists, physicians, mental health students, and policymakers. Its goal is to facilitate the exchange of research findings and clinical practices between Asia and the global community. The journal focuses on psychiatric research relevant to Asia, covering preclinical, clinical, service system, and policy development topics. It also highlights the socio-cultural diversity of the region in relation to mental health.