结直肠癌的风险和参与粪便免疫化学测试筛查

IF 3.2 3区医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Public Health Pub Date : 2025-09-08 DOI:10.1016/j.puhe.2025.105938

H.J. van de Schootbrugge-Vandermeer , L. de Jonge , M.E. van Leerdam , A.J. van Vuuren , E. Dekker , M.C.W. Spaander , I.D. Nagtegaal , F.J. van Kemenade , I. Lansdorp-Vogelaar , E. Toes-Zoutendijk

{"title":"结直肠癌的风险和参与粪便免疫化学测试筛查","authors":"H.J. van de Schootbrugge-Vandermeer , L. de Jonge , M.E. van Leerdam , A.J. van Vuuren , E. Dekker , M.C.W. Spaander , I.D. Nagtegaal , F.J. van Kemenade , I. Lansdorp-Vogelaar , E. Toes-Zoutendijk","doi":"10.1016/j.puhe.2025.105938","DOIUrl":null,"url":null,"abstract":"<div><h3>Objectives</h3><div>Participation rates in fecal immunochemical test (FIT)-based colorectal cancer (CRC) screening differ across socio-demographic subgroups. The largest health gains could be achieved in subgroups with low participation rates and high risk of CRC. We investigated the CRC risk within different socio-demographic subgroups with low participation in the Dutch CRC screening program.</div></div><div><h3>Study design</h3><div>Population-based cohort study.</div></div><div><h3>Methods</h3><div>All individuals invited for the Dutch CRC screening program in 2018 and 2019 were included. Data from a previous study, including screening data and demographic characteristics, were augmented with CRC diagnoses in 2018 and 2019. A multivariable logistic regression was used to assess the association between socio-demographic factors and risk of CRC.</div></div><div><h3>Results</h3><div>Overall participation was 72.3% and age-adjusted CRC incidence was 30.3 per 10,000 individuals. Males showed lower participation (69.7 %) but had a higher-than-average CRC risk (35.1). The difference in CRC risk between males and females was less pronounced among non-participants (OR: 1.28, 95% CI: 1.20–1.36) than participants (OR: 1.41, 95% CI: 1.35–1.47). Lower income groups also had lower participation (down to 60.0 %) and higher risk of CRC (down to 30.7), but the difference in CRC risk between low-income groups and high-income groups was only significant among participants (OR lowest vs highest quintile: 1.22, 95% CI: 1.14–1.32). Conversely, individuals with a Turkish/Moroccan migration background had lower participation (48.7 %), but their CRC risk was also lower (18.8; OR: 0.54, 95% CI: 0.46–0.63).</div></div><div><h3>Conclusions</h3><div>CRC risk varies significantly between low-participation groups in the Dutch CRC screening program. Interventions should prioritize the most vulnerable groups, considering both participation and risk of CRC.</div></div>","PeriodicalId":49651,"journal":{"name":"Public Health","volume":"248 ","pages":"Article 105938"},"PeriodicalIF":3.2000,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Risk of colorectal cancer and participation in fecal immunochemical test-based screening\",\"authors\":\"H.J. van de Schootbrugge-Vandermeer , L. de Jonge , M.E. van Leerdam , A.J. van Vuuren , E. Dekker , M.C.W. Spaander , I.D. Nagtegaal , F.J. van Kemenade , I. Lansdorp-Vogelaar , E. Toes-Zoutendijk\",\"doi\":\"10.1016/j.puhe.2025.105938\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Objectives</h3><div>Participation rates in fecal immunochemical test (FIT)-based colorectal cancer (CRC) screening differ across socio-demographic subgroups. The largest health gains could be achieved in subgroups with low participation rates and high risk of CRC. We investigated the CRC risk within different socio-demographic subgroups with low participation in the Dutch CRC screening program.</div></div><div><h3>Study design</h3><div>Population-based cohort study.</div></div><div><h3>Methods</h3><div>All individuals invited for the Dutch CRC screening program in 2018 and 2019 were included. Data from a previous study, including screening data and demographic characteristics, were augmented with CRC diagnoses in 2018 and 2019. A multivariable logistic regression was used to assess the association between socio-demographic factors and risk of CRC.</div></div><div><h3>Results</h3><div>Overall participation was 72.3% and age-adjusted CRC incidence was 30.3 per 10,000 individuals. Males showed lower participation (69.7 %) but had a higher-than-average CRC risk (35.1). The difference in CRC risk between males and females was less pronounced among non-participants (OR: 1.28, 95% CI: 1.20–1.36) than participants (OR: 1.41, 95% CI: 1.35–1.47). Lower income groups also had lower participation (down to 60.0 %) and higher risk of CRC (down to 30.7), but the difference in CRC risk between low-income groups and high-income groups was only significant among participants (OR lowest vs highest quintile: 1.22, 95% CI: 1.14–1.32). Conversely, individuals with a Turkish/Moroccan migration background had lower participation (48.7 %), but their CRC risk was also lower (18.8; OR: 0.54, 95% CI: 0.46–0.63).</div></div><div><h3>Conclusions</h3><div>CRC risk varies significantly between low-participation groups in the Dutch CRC screening program. Interventions should prioritize the most vulnerable groups, considering both participation and risk of CRC.</div></div>\",\"PeriodicalId\":49651,\"journal\":{\"name\":\"Public Health\",\"volume\":\"248 \",\"pages\":\"Article 105938\"},\"PeriodicalIF\":3.2000,\"publicationDate\":\"2025-09-08\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Public Health\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0033350625003841\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Public Health","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0033350625003841","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH","Score":null,"Total":0}

引用次数: 0

摘要

目的基于粪便免疫化学试验（FIT）的结直肠癌（CRC）筛查的参与率在不同的社会人口亚组中存在差异。最大的健康收益可以在低参与率和CRC高风险的亚组中实现。我们调查了参与荷兰CRC筛查计划的不同社会人口亚组的CRC风险。研究设计基于人群的队列研究。方法纳入2018年和2019年荷兰CRC筛查项目邀请的所有个体。先前研究的数据，包括筛查数据和人口统计学特征，在2018年和2019年得到了CRC诊断的补充。采用多变量logistic回归来评估社会人口因素与结直肠癌风险之间的关系。结果总体参与率为72.3%，年龄调整后的CRC发病率为30.3 / 10000人。男性的参与率较低（69.7%），但CRC风险高于平均水平（35.1%）。在非参与者中，男性和女性之间结直肠癌风险的差异（OR: 1.28, 95% CI: 1.20-1.36）比参与者（OR: 1.41, 95% CI: 1.35-1.47）更不明显。低收入群体也有较低的参与度（降至60.0%）和较高的CRC风险（降至30.7%），但低收入群体和高收入群体之间的CRC风险差异仅在参与者中显着（OR最低五分位数vs最高五分位数：1.22,95% CI: 1.14-1.32）。相反，具有土耳其/摩洛哥移民背景的个体参与率较低（48.7%），但他们的CRC风险也较低（18.8;OR: 0.54, 95% CI: 0.46-0.63）。结论在荷兰CRC筛查项目中，低参与率组的CRC风险差异显著。干预措施应优先考虑最弱势群体的参与和CRC的风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Risk of colorectal cancer and participation in fecal immunochemical test-based screening

Objectives

Participation rates in fecal immunochemical test (FIT)-based colorectal cancer (CRC) screening differ across socio-demographic subgroups. The largest health gains could be achieved in subgroups with low participation rates and high risk of CRC. We investigated the CRC risk within different socio-demographic subgroups with low participation in the Dutch CRC screening program.

Study design

Population-based cohort study.

Methods

All individuals invited for the Dutch CRC screening program in 2018 and 2019 were included. Data from a previous study, including screening data and demographic characteristics, were augmented with CRC diagnoses in 2018 and 2019. A multivariable logistic regression was used to assess the association between socio-demographic factors and risk of CRC.

Results

Overall participation was 72.3% and age-adjusted CRC incidence was 30.3 per 10,000 individuals. Males showed lower participation (69.7 %) but had a higher-than-average CRC risk (35.1). The difference in CRC risk between males and females was less pronounced among non-participants (OR: 1.28, 95% CI: 1.20–1.36) than participants (OR: 1.41, 95% CI: 1.35–1.47). Lower income groups also had lower participation (down to 60.0 %) and higher risk of CRC (down to 30.7), but the difference in CRC risk between low-income groups and high-income groups was only significant among participants (OR lowest vs highest quintile: 1.22, 95% CI: 1.14–1.32). Conversely, individuals with a Turkish/Moroccan migration background had lower participation (48.7 %), but their CRC risk was also lower (18.8; OR: 0.54, 95% CI: 0.46–0.63).

Conclusions

CRC risk varies significantly between low-participation groups in the Dutch CRC screening program. Interventions should prioritize the most vulnerable groups, considering both participation and risk of CRC.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Public Health 医学-公共卫生、环境卫生与职业卫生

CiteScore

7.60

自引率

0.00%

发文量

280

审稿时长

37 days

期刊介绍： Public Health is an international, multidisciplinary peer-reviewed journal. It publishes original papers, reviews and short reports on all aspects of the science, philosophy, and practice of public health.