类鼻炎患者BimABm阳性及其对临床表现和结果的影响：一项回顾性队列研究

IF 1.7 Q4 INFECTIOUS DISEASES

IJID regions Pub Date : 2025-09-01 DOI:10.1016/j.ijregi.2025.100723

Nitin Gupta , Tirlangi Praveen Kumar , Soumi Chowdhury , Chiranjay Mukhopadhyay

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引用次数: 0

摘要

目的假性伯克霍尔德菌引起的类鼻疽病临床表现多样。神经系统受累虽然罕见，但却是一种严重的并发症。BimABm等位基因是伯克霍尔德氏菌胞内运动a （BimA）毒力基因的一种变体，与嗜神经性有关，但来自印度的这一关联的数据有限。方法：我们对印度南部一家三级保健中心138例经培养证实的类鼻疽患者进行了回顾性队列研究。采用聚合酶链反应法检测存档分离株的BimABm等位基因。比较BimABm阳性组和阴性组的临床特征和28天死亡率。结果在5.8%的分离株中检出BimABm等位基因。神经系统受累在bimabm阳性患者中更为常见（50% [4/8]vs 2.3% [3/130], P < 0.001）。两组患者的合并症和28天死亡率无显著差异。结论BimABm等位基因虽然不常见，但与印度南部神经性类鼻瘤病密切相关。

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BimABm positivity in melioidosis and its impact on clinical profile, and outcomes: a retrospective cohort study

Objectives

Melioidosis, caused by Burkholderia pseudomallei presents with diverse clinical features. Neurological involvement, though rare, is a severe complication. The BimA_Bm allele, a variant of the Burkholderia intracellular motility A (BimA) virulence gene, has been linked to neurotropism, but data from India on this association are limited.

Methods

We conducted a retrospective cohort study of 138 culture-confirmed melioidosis patients at a tertiary care center in southern India. A polymerase chain reaction assay was used to detect the BimA_Bm allele in archived isolates. Clinical features and 28-day mortality were compared between BimA_Bm -positive and -negative groups.

Results

The BimA_Bm allele was detected in 5.8% of isolates. Neurological involvement was significantly more common in BimA_Bm-positive patients (50% [4/8] vs 2.3% [3/130], P < 0.001). No significant differences in comorbidities or 28-day mortality were observed between the two groups.