Edmund C. Mbegbu , Ikechukwu R. Obidike , Chinelo G. Ikele , Patience C. Ugwu , Chuka Ezema , Lawrence O. Aka , Abdussamad M. Abdussamad , John J. Parrish
{"title":"酿酒酵母益生菌对阴囊局部热暴露后免疫反应、睾丸功能、血清垂体性腺激素和应激标志物的影响","authors":"Edmund C. Mbegbu , Ikechukwu R. Obidike , Chinelo G. Ikele , Patience C. Ugwu , Chuka Ezema , Lawrence O. Aka , Abdussamad M. Abdussamad , John J. Parrish","doi":"10.1016/j.jtherbio.2025.104261","DOIUrl":null,"url":null,"abstract":"<div><div>Owing to the anti-inflammatory and anti-oxidant benefits of <em>Saccharomyces cerevisiae</em> (SC), 20 mature male albino rats, assigned into four groups (A-D; n = 5), were used to investigate its ameliorative effects on heat stress-induced testicular and humoral alterations. Group A rats were neither treated with SC nor exposed to heat [-SC, -HS]. Group B rats were treated with 7 mg/kg of SC<em>,</em> but were not exposed to heat [+SC, -HS]. Group C rats did not receive 7 mg/kg of SC<em>,</em> but were exposed to heat at 43 °C for 15 min [-SC, +HS]. Group D rats were treated with 7 mg/kg of SC<em>,</em> and were exposed to heat at 43 °C for 15 min [+SC, +HS]. Probiotic administration was done orally every other day for five consecutive weeks, when blood and testicular samples were collected for analyses. Probiotic treatment after heat exposure significantly increased (<em>p</em> < 0.05) the total WBC, lymphocyte count, neutrophil count and monocyte count. Cortisol concentration significantly increased (<em>p < 0.05</em>) in Groups B-D, while only Group C had a significantly higher (<em>p < 0.05</em>) total cholesterol. Exposure to heat (in Groups C and D) significantly decreased (p < 0.05) the mean left and right testicular weights, as well as the testicular and epididymal sperm counts. The histology of the testis revealed regeneration of the germinal epithelium of the seminiferous tubules in the group exposed to heat and treated with SC. Findings from this work proved that the probiotic potentials of SC could be harnessed for mitigating heat-induced humoral and spermatogenic alterations in male albino rats.</div></div>","PeriodicalId":17428,"journal":{"name":"Journal of thermal biology","volume":"132 ","pages":"Article 104261"},"PeriodicalIF":2.9000,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Probiotic effects of Saccharomyces cerevisiae on immune response, testicular function, serum pituitary-gonadal hormones and stress markers following localized scrotal heat exposure\",\"authors\":\"Edmund C. Mbegbu , Ikechukwu R. Obidike , Chinelo G. Ikele , Patience C. Ugwu , Chuka Ezema , Lawrence O. Aka , Abdussamad M. Abdussamad , John J. Parrish\",\"doi\":\"10.1016/j.jtherbio.2025.104261\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Owing to the anti-inflammatory and anti-oxidant benefits of <em>Saccharomyces cerevisiae</em> (SC), 20 mature male albino rats, assigned into four groups (A-D; n = 5), were used to investigate its ameliorative effects on heat stress-induced testicular and humoral alterations. Group A rats were neither treated with SC nor exposed to heat [-SC, -HS]. Group B rats were treated with 7 mg/kg of SC<em>,</em> but were not exposed to heat [+SC, -HS]. Group C rats did not receive 7 mg/kg of SC<em>,</em> but were exposed to heat at 43 °C for 15 min [-SC, +HS]. Group D rats were treated with 7 mg/kg of SC<em>,</em> and were exposed to heat at 43 °C for 15 min [+SC, +HS]. Probiotic administration was done orally every other day for five consecutive weeks, when blood and testicular samples were collected for analyses. Probiotic treatment after heat exposure significantly increased (<em>p</em> < 0.05) the total WBC, lymphocyte count, neutrophil count and monocyte count. Cortisol concentration significantly increased (<em>p < 0.05</em>) in Groups B-D, while only Group C had a significantly higher (<em>p < 0.05</em>) total cholesterol. Exposure to heat (in Groups C and D) significantly decreased (p < 0.05) the mean left and right testicular weights, as well as the testicular and epididymal sperm counts. The histology of the testis revealed regeneration of the germinal epithelium of the seminiferous tubules in the group exposed to heat and treated with SC. Findings from this work proved that the probiotic potentials of SC could be harnessed for mitigating heat-induced humoral and spermatogenic alterations in male albino rats.</div></div>\",\"PeriodicalId\":17428,\"journal\":{\"name\":\"Journal of thermal biology\",\"volume\":\"132 \",\"pages\":\"Article 104261\"},\"PeriodicalIF\":2.9000,\"publicationDate\":\"2025-08-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of thermal biology\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0306456525002189\",\"RegionNum\":2,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of thermal biology","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0306456525002189","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOLOGY","Score":null,"Total":0}
Probiotic effects of Saccharomyces cerevisiae on immune response, testicular function, serum pituitary-gonadal hormones and stress markers following localized scrotal heat exposure
Owing to the anti-inflammatory and anti-oxidant benefits of Saccharomyces cerevisiae (SC), 20 mature male albino rats, assigned into four groups (A-D; n = 5), were used to investigate its ameliorative effects on heat stress-induced testicular and humoral alterations. Group A rats were neither treated with SC nor exposed to heat [-SC, -HS]. Group B rats were treated with 7 mg/kg of SC, but were not exposed to heat [+SC, -HS]. Group C rats did not receive 7 mg/kg of SC, but were exposed to heat at 43 °C for 15 min [-SC, +HS]. Group D rats were treated with 7 mg/kg of SC, and were exposed to heat at 43 °C for 15 min [+SC, +HS]. Probiotic administration was done orally every other day for five consecutive weeks, when blood and testicular samples were collected for analyses. Probiotic treatment after heat exposure significantly increased (p < 0.05) the total WBC, lymphocyte count, neutrophil count and monocyte count. Cortisol concentration significantly increased (p < 0.05) in Groups B-D, while only Group C had a significantly higher (p < 0.05) total cholesterol. Exposure to heat (in Groups C and D) significantly decreased (p < 0.05) the mean left and right testicular weights, as well as the testicular and epididymal sperm counts. The histology of the testis revealed regeneration of the germinal epithelium of the seminiferous tubules in the group exposed to heat and treated with SC. Findings from this work proved that the probiotic potentials of SC could be harnessed for mitigating heat-induced humoral and spermatogenic alterations in male albino rats.
期刊介绍:
The Journal of Thermal Biology publishes articles that advance our knowledge on the ways and mechanisms through which temperature affects man and animals. This includes studies of their responses to these effects and on the ecological consequences. Directly relevant to this theme are:
• The mechanisms of thermal limitation, heat and cold injury, and the resistance of organisms to extremes of temperature
• The mechanisms involved in acclimation, acclimatization and evolutionary adaptation to temperature
• Mechanisms underlying the patterns of hibernation, torpor, dormancy, aestivation and diapause
• Effects of temperature on reproduction and development, growth, ageing and life-span
• Studies on modelling heat transfer between organisms and their environment
• The contributions of temperature to effects of climate change on animal species and man
• Studies of conservation biology and physiology related to temperature
• Behavioural and physiological regulation of body temperature including its pathophysiology and fever
• Medical applications of hypo- and hyperthermia
Article types:
• Original articles
• Review articles