RNA测序在分子肿瘤学中的作用

IF 50 1区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Nature Medicine Pub Date : 2025-09-09 DOI:10.1038/s41591-025-03973-4

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引用次数: 0

摘要

我们通过分析从婴儿到老年人的大规模泛癌症队列，评估了RNA测序在分子诊断中的效用。该技术对基因改变的识别高度敏感，可以指导诊断和靶向治疗，并且可以对标准dna测序方案之外的发现进行额外的生物学和临床解释。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

The power of RNA sequencing in molecular oncology

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The power of RNA sequencing in molecular oncology

We assessed the utility of RNA sequencing in molecular diagnostics by analyzing a large pan-cancer cohort ranging in age from infants to seniors. This technique is highly sensitive for the identification of gene alterations that can guide diagnosis and targeted therapy, and enables additional biological and clinical interpretation of findings beyond standard DNA-sequencing protocols.

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来源期刊

Nature Medicine 医学-生化与分子生物学

CiteScore

100.90

自引率

0.70%

发文量

525

审稿时长

1 months

期刊介绍： Nature Medicine is a monthly journal publishing original peer-reviewed research in all areas of medicine. The publication focuses on originality, timeliness, interdisciplinary interest, and the impact on improving human health. In addition to research articles, Nature Medicine also publishes commissioned content such as News, Reviews, and Perspectives. This content aims to provide context for the latest advances in translational and clinical research, reaching a wide audience of M.D. and Ph.D. readers. All editorial decisions for the journal are made by a team of full-time professional editors. Nature Medicine consider all types of clinical research, including: -Case-reports and small case series -Clinical trials, whether phase 1, 2, 3 or 4 -Observational studies -Meta-analyses -Biomarker studies -Public and global health studies Nature Medicine is also committed to facilitating communication between translational and clinical researchers. As such, we consider “hybrid” studies with preclinical and translational findings reported alongside data from clinical studies.