纵向多模态磁共振成像揭示中重度创伤性脑损伤患者语言流畅性随时间的改善。

IF 1.8 Q3 CLINICAL NEUROLOGY
Neurotrauma reports Pub Date : 2025-07-28 eCollection Date: 2025-01-01 DOI:10.1089/neur.2024.0149
Ana Luiza Zaninotto, Fabiola Macruz, Fabricio S Feltrin, Celi S Andrade, Claudia C Leite, Vinicius Monteiro de Paula Guirado, Wellingson S Paiva, Sylvain Bouix
{"title":"纵向多模态磁共振成像揭示中重度创伤性脑损伤患者语言流畅性随时间的改善。","authors":"Ana Luiza Zaninotto, Fabiola Macruz, Fabricio S Feltrin, Celi S Andrade, Claudia C Leite, Vinicius Monteiro de Paula Guirado, Wellingson S Paiva, Sylvain Bouix","doi":"10.1089/neur.2024.0149","DOIUrl":null,"url":null,"abstract":"<p><p>Most individuals with moderate-to-severe diffuse axonal injury (DAI) have impaired verbal fluency (VF) capacity. Still, the relationship between brain and VF recovery post-DAI has remained mostly unknown. The aim was to assess brain changes in 13 cortical thickness regions of interest (ROIs), fractional anisotropy (FA), and free water (FW) in three language-related tracts; the VF performance at 6 and 12 months after the DAI; and whether brain changes from 3 to 6 months predict VF performance from 6- to 12-month post-DAI. Twenty-one adults with moderate and severe DAI were analyzed. Structural and diffusion data were acquired on a 3T system 3 and 6 months after the injury. The differences in cortical thickness, FA, and FW values over time were analyzed as factors for the phonemic and semantic VF scores between the 6th and 12th months following the DAI. All analyses were corrected for multiple comparisons. Cortical thickness increased over time in 7 of the 13 ROIs in the right hemisphere and 5 of the 13 ROIs in the left hemisphere. There was an increase in FA in the right arcuate fasciculus and the inferior longitudinal fasciculus over time. An increase in phonemic VF scores was detected between 6 and 12 months post-traumatic brain injury, but not in semantic VF scores over time. Cortical thickness changes in the left posterior inferior frontal pars opercularis and left anterior superior temporal sulcus from 3 to 6 months were associated with improved phonemic VF scores over time. There was no association between diffusion magnetic resonance imaging metrics and VF scores. Our findings suggest that brain plasticity plays a significant role in the initial year following traumatic brain injury, as evidenced by increased cortical thickness and white matter integrity. Improved VF is associated with increased thickness in cortical motor regions responsible for speech performance. However, a larger sample size is needed to confirm these findings.</p>","PeriodicalId":74300,"journal":{"name":"Neurotrauma reports","volume":"6 1","pages":"600-612"},"PeriodicalIF":1.8000,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12413258/pdf/","citationCount":"0","resultStr":"{\"title\":\"Longitudinal Multimodal Magnetic Resonance Imaging Reveals Improvement in Verbal Fluency Over Time in Moderate-to-Severe Traumatic Brain Injury.\",\"authors\":\"Ana Luiza Zaninotto, Fabiola Macruz, Fabricio S Feltrin, Celi S Andrade, Claudia C Leite, Vinicius Monteiro de Paula Guirado, Wellingson S Paiva, Sylvain Bouix\",\"doi\":\"10.1089/neur.2024.0149\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Most individuals with moderate-to-severe diffuse axonal injury (DAI) have impaired verbal fluency (VF) capacity. Still, the relationship between brain and VF recovery post-DAI has remained mostly unknown. The aim was to assess brain changes in 13 cortical thickness regions of interest (ROIs), fractional anisotropy (FA), and free water (FW) in three language-related tracts; the VF performance at 6 and 12 months after the DAI; and whether brain changes from 3 to 6 months predict VF performance from 6- to 12-month post-DAI. Twenty-one adults with moderate and severe DAI were analyzed. Structural and diffusion data were acquired on a 3T system 3 and 6 months after the injury. The differences in cortical thickness, FA, and FW values over time were analyzed as factors for the phonemic and semantic VF scores between the 6th and 12th months following the DAI. All analyses were corrected for multiple comparisons. Cortical thickness increased over time in 7 of the 13 ROIs in the right hemisphere and 5 of the 13 ROIs in the left hemisphere. There was an increase in FA in the right arcuate fasciculus and the inferior longitudinal fasciculus over time. An increase in phonemic VF scores was detected between 6 and 12 months post-traumatic brain injury, but not in semantic VF scores over time. Cortical thickness changes in the left posterior inferior frontal pars opercularis and left anterior superior temporal sulcus from 3 to 6 months were associated with improved phonemic VF scores over time. There was no association between diffusion magnetic resonance imaging metrics and VF scores. Our findings suggest that brain plasticity plays a significant role in the initial year following traumatic brain injury, as evidenced by increased cortical thickness and white matter integrity. Improved VF is associated with increased thickness in cortical motor regions responsible for speech performance. However, a larger sample size is needed to confirm these findings.</p>\",\"PeriodicalId\":74300,\"journal\":{\"name\":\"Neurotrauma reports\",\"volume\":\"6 1\",\"pages\":\"600-612\"},\"PeriodicalIF\":1.8000,\"publicationDate\":\"2025-07-28\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12413258/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Neurotrauma reports\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1089/neur.2024.0149\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q3\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neurotrauma reports","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1089/neur.2024.0149","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q3","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
引用次数: 0

摘要

大多数中重度弥漫性轴索损伤(DAI)患者的语言流畅性(VF)能力受损。然而,dai后大脑和VF恢复之间的关系仍然是未知的。目的是评估三个语言相关束的13个皮层厚度感兴趣区(roi)、分数各向异性区(FA)和游离水区(FW)的大脑变化;DAI后6个月和12个月的VF表现;以及3到6个月的大脑变化是否能预测dai后6到12个月的VF表现。对21例成人中重度DAI进行分析。损伤后3个月和6个月在3T系统上获得结构和扩散数据。在DAI后的第6个月和第12个月之间,分析皮质厚度、FA和FW值随时间的差异作为音素和语义VF评分的因素。所有分析都进行了多重比较校正。右半球13个roi中的7个和左半球13个roi中的5个皮质厚度随时间增加。随着时间的推移,右弓状束和下纵束的FA增加。在创伤性脑损伤后6至12个月,音素VF得分有所增加,但语义VF得分没有随时间增加。3 - 6个月时,左侧额下后小包部和左侧颞前上沟的皮质厚度变化与音位VF评分随时间的提高有关。扩散磁共振成像指标与VF评分之间没有关联。我们的研究结果表明,大脑可塑性在创伤性脑损伤后的头一年起着重要作用,这一点可以通过皮质厚度和白质完整性的增加来证明。VF的改善与负责语言表现的皮质运动区厚度的增加有关。然而,需要更大的样本量来证实这些发现。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Longitudinal Multimodal Magnetic Resonance Imaging Reveals Improvement in Verbal Fluency Over Time in Moderate-to-Severe Traumatic Brain Injury.

Longitudinal Multimodal Magnetic Resonance Imaging Reveals Improvement in Verbal Fluency Over Time in Moderate-to-Severe Traumatic Brain Injury.

Longitudinal Multimodal Magnetic Resonance Imaging Reveals Improvement in Verbal Fluency Over Time in Moderate-to-Severe Traumatic Brain Injury.

Longitudinal Multimodal Magnetic Resonance Imaging Reveals Improvement in Verbal Fluency Over Time in Moderate-to-Severe Traumatic Brain Injury.

Most individuals with moderate-to-severe diffuse axonal injury (DAI) have impaired verbal fluency (VF) capacity. Still, the relationship between brain and VF recovery post-DAI has remained mostly unknown. The aim was to assess brain changes in 13 cortical thickness regions of interest (ROIs), fractional anisotropy (FA), and free water (FW) in three language-related tracts; the VF performance at 6 and 12 months after the DAI; and whether brain changes from 3 to 6 months predict VF performance from 6- to 12-month post-DAI. Twenty-one adults with moderate and severe DAI were analyzed. Structural and diffusion data were acquired on a 3T system 3 and 6 months after the injury. The differences in cortical thickness, FA, and FW values over time were analyzed as factors for the phonemic and semantic VF scores between the 6th and 12th months following the DAI. All analyses were corrected for multiple comparisons. Cortical thickness increased over time in 7 of the 13 ROIs in the right hemisphere and 5 of the 13 ROIs in the left hemisphere. There was an increase in FA in the right arcuate fasciculus and the inferior longitudinal fasciculus over time. An increase in phonemic VF scores was detected between 6 and 12 months post-traumatic brain injury, but not in semantic VF scores over time. Cortical thickness changes in the left posterior inferior frontal pars opercularis and left anterior superior temporal sulcus from 3 to 6 months were associated with improved phonemic VF scores over time. There was no association between diffusion magnetic resonance imaging metrics and VF scores. Our findings suggest that brain plasticity plays a significant role in the initial year following traumatic brain injury, as evidenced by increased cortical thickness and white matter integrity. Improved VF is associated with increased thickness in cortical motor regions responsible for speech performance. However, a larger sample size is needed to confirm these findings.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
CiteScore
2.40
自引率
0.00%
发文量
0
审稿时长
8 weeks
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信