{"title":"近视眼黄斑光学相干断层成像参数与青光眼的关系。","authors":"Wei Ma, Xinyi Li, Liqing Xie, Feng Jiang, Mingguang He, Decai Wang, Zhixi Li","doi":"10.1167/tvst.14.9.12","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>The purpose of this study was to estimate the correlations between macular optical coherence tomography (OCT)-derived metrics and incident glaucoma risk in myopic eyes.</p><p><strong>Methods: </strong>This longitudinal observational study included 24,181 individuals with myopia (spherical equivalence [SE] ≤ -0.5 diopters [D]) from the UK Biobank study.</p><p><strong>Results: </strong>Participants (mean age = 55.5 ± 8.0 years, 54.5% women) were followed up for 13.2 ± 1.2 years and incident glaucoma was diagnosed in 582 eyes. Those who developed glaucoma were significantly older (P < 0.001), more likely to be male participants (P < 0.001), and had more pronounced myopic refractive error (P < 0.001). Cox regression analyses indicated that participants with thinner retinal nerve fiber layer (RNFL; hazard ratio [HR] = 0.97, 95% confidence interval [CI] = 0.96-0.99, P < 0.001), thinner ganglion cell-inner plexiform layer (GCIPL; HR = 0.97, 95% CI = 0.96-0.98, P < 0.001), and thinner ganglion cell complex (GCC; HR = 0.98, 95% CI = 0.97-0.99, P < 0.001) had an increasing risk of incident glaucoma after adjustment for age, sex, ethnic group, and SE. Meanwhile, the thicker inner nuclear layer (INL; HR = 1.03, 95% CI = 1.01-1.05, P = 0.002) and photoreceptor segments (PS; HR = 1.03, 95% CI = 1.01-1.06, P = 0.024) were positive for the incidence of glaucoma.</p><p><strong>Conclusions: </strong>This longitudinal study suggested that baseline RNFL, GCIPL, GCC, INL, and PS thickness were significant predictors for the incidence of glaucoma among myopic participants, which indicated a pattern of internal layer thinning (except INL) and outer layer thickening in these pre-glaucoma participants.</p><p><strong>Translational relevance: </strong>Our study highlighted the potential of OCT-derived indicators for early glaucoma risk assessment and clinical monitoring.</p>","PeriodicalId":23322,"journal":{"name":"Translational Vision Science & Technology","volume":"14 9","pages":"12"},"PeriodicalIF":2.6000,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12422395/pdf/","citationCount":"0","resultStr":"{\"title\":\"Macular Optical Coherence Tomography Parameters and Incident Glaucoma Among Myopic Eyes.\",\"authors\":\"Wei Ma, Xinyi Li, Liqing Xie, Feng Jiang, Mingguang He, Decai Wang, Zhixi Li\",\"doi\":\"10.1167/tvst.14.9.12\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>The purpose of this study was to estimate the correlations between macular optical coherence tomography (OCT)-derived metrics and incident glaucoma risk in myopic eyes.</p><p><strong>Methods: </strong>This longitudinal observational study included 24,181 individuals with myopia (spherical equivalence [SE] ≤ -0.5 diopters [D]) from the UK Biobank study.</p><p><strong>Results: </strong>Participants (mean age = 55.5 ± 8.0 years, 54.5% women) were followed up for 13.2 ± 1.2 years and incident glaucoma was diagnosed in 582 eyes. Those who developed glaucoma were significantly older (P < 0.001), more likely to be male participants (P < 0.001), and had more pronounced myopic refractive error (P < 0.001). Cox regression analyses indicated that participants with thinner retinal nerve fiber layer (RNFL; hazard ratio [HR] = 0.97, 95% confidence interval [CI] = 0.96-0.99, P < 0.001), thinner ganglion cell-inner plexiform layer (GCIPL; HR = 0.97, 95% CI = 0.96-0.98, P < 0.001), and thinner ganglion cell complex (GCC; HR = 0.98, 95% CI = 0.97-0.99, P < 0.001) had an increasing risk of incident glaucoma after adjustment for age, sex, ethnic group, and SE. Meanwhile, the thicker inner nuclear layer (INL; HR = 1.03, 95% CI = 1.01-1.05, P = 0.002) and photoreceptor segments (PS; HR = 1.03, 95% CI = 1.01-1.06, P = 0.024) were positive for the incidence of glaucoma.</p><p><strong>Conclusions: </strong>This longitudinal study suggested that baseline RNFL, GCIPL, GCC, INL, and PS thickness were significant predictors for the incidence of glaucoma among myopic participants, which indicated a pattern of internal layer thinning (except INL) and outer layer thickening in these pre-glaucoma participants.</p><p><strong>Translational relevance: </strong>Our study highlighted the potential of OCT-derived indicators for early glaucoma risk assessment and clinical monitoring.</p>\",\"PeriodicalId\":23322,\"journal\":{\"name\":\"Translational Vision Science & Technology\",\"volume\":\"14 9\",\"pages\":\"12\"},\"PeriodicalIF\":2.6000,\"publicationDate\":\"2025-09-02\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12422395/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Translational Vision Science & Technology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1167/tvst.14.9.12\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"OPHTHALMOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Translational Vision Science & Technology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1167/tvst.14.9.12","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"OPHTHALMOLOGY","Score":null,"Total":0}
引用次数: 0
摘要
目的：本研究的目的是估计黄斑光学相干断层扫描（OCT）衍生指标与近视眼睛发生青光眼风险之间的相关性。方法：这项纵向观察研究包括来自英国生物银行研究的24181名近视患者（球形等度[SE]≤-0.5屈光度[D]）。结果：平均年龄55.5±8.0岁，女性54.5%，随访13.2±1.2年，确诊青光眼582眼。青光眼患者明显年龄较大（P < 0.001），男性参与者较多（P < 0.001），近视屈光不正患者较多（P < 0.001）。Cox回归分析表明，在调整年龄、性别、种族和SE后，视网膜神经纤维层（RNFL；风险比[HR] = 0.97, 95%可信区间[CI] = 0.96-0.99, P < 0.001）、神经节细胞-内丛状层（GCIPL; HR = 0.97, 95% CI = 0.96-0.98, P < 0.001）较薄的受试者发生青光眼的风险增加。同时，较厚的内核层（INL; HR = 1.03, 95% CI = 1.01-1.05, P = 0.002）和光感受器段（PS; HR = 1.03, 95% CI = 1.01-1.06, P = 0.024）与青光眼的发病率呈正相关。结论：这项纵向研究表明，基线RNFL、GCIPL、GCC、INL和PS厚度是近视参与者青光眼发病率的重要预测因素，这表明这些青光眼前期参与者存在内层变薄（INL除外）和外层增厚的模式。翻译相关性：我们的研究强调了oct衍生指标在早期青光眼风险评估和临床监测中的潜力。
Macular Optical Coherence Tomography Parameters and Incident Glaucoma Among Myopic Eyes.
Purpose: The purpose of this study was to estimate the correlations between macular optical coherence tomography (OCT)-derived metrics and incident glaucoma risk in myopic eyes.
Methods: This longitudinal observational study included 24,181 individuals with myopia (spherical equivalence [SE] ≤ -0.5 diopters [D]) from the UK Biobank study.
Results: Participants (mean age = 55.5 ± 8.0 years, 54.5% women) were followed up for 13.2 ± 1.2 years and incident glaucoma was diagnosed in 582 eyes. Those who developed glaucoma were significantly older (P < 0.001), more likely to be male participants (P < 0.001), and had more pronounced myopic refractive error (P < 0.001). Cox regression analyses indicated that participants with thinner retinal nerve fiber layer (RNFL; hazard ratio [HR] = 0.97, 95% confidence interval [CI] = 0.96-0.99, P < 0.001), thinner ganglion cell-inner plexiform layer (GCIPL; HR = 0.97, 95% CI = 0.96-0.98, P < 0.001), and thinner ganglion cell complex (GCC; HR = 0.98, 95% CI = 0.97-0.99, P < 0.001) had an increasing risk of incident glaucoma after adjustment for age, sex, ethnic group, and SE. Meanwhile, the thicker inner nuclear layer (INL; HR = 1.03, 95% CI = 1.01-1.05, P = 0.002) and photoreceptor segments (PS; HR = 1.03, 95% CI = 1.01-1.06, P = 0.024) were positive for the incidence of glaucoma.
Conclusions: This longitudinal study suggested that baseline RNFL, GCIPL, GCC, INL, and PS thickness were significant predictors for the incidence of glaucoma among myopic participants, which indicated a pattern of internal layer thinning (except INL) and outer layer thickening in these pre-glaucoma participants.
Translational relevance: Our study highlighted the potential of OCT-derived indicators for early glaucoma risk assessment and clinical monitoring.
期刊介绍：
Translational Vision Science & Technology (TVST), an official journal of the Association for Research in Vision and Ophthalmology (ARVO), an international organization whose purpose is to advance research worldwide into understanding the visual system and preventing, treating and curing its disorders, is an online, open access, peer-reviewed journal emphasizing multidisciplinary research that bridges the gap between basic research and clinical care. A highly qualified and diverse group of Associate Editors and Editorial Board Members is led by Editor-in-Chief Marco Zarbin, MD, PhD, FARVO.
The journal covers a broad spectrum of work, including but not limited to:
Applications of stem cell technology for regenerative medicine,
Development of new animal models of human diseases,
Tissue bioengineering,
Chemical engineering to improve virus-based gene delivery,
Nanotechnology for drug delivery,
Design and synthesis of artificial extracellular matrices,
Development of a true microsurgical operating environment,
Refining data analysis algorithms to improve in vivo imaging technology,
Results of Phase 1 clinical trials,
Reverse translational ("bedside to bench") research.
TVST seeks manuscripts from scientists and clinicians with diverse backgrounds ranging from basic chemistry to ophthalmic surgery that will advance or change the way we understand and/or treat vision-threatening diseases. TVST encourages the use of color, multimedia, hyperlinks, program code and other digital enhancements.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
