脉络膜血管指数作为健康和疾病的标志:系统回顾和荟萃分析。

IF 5.9 2区 医学 Q1 OPHTHALMOLOGY
Nicholas Chieh Loh, William Rojas-Carabali, Yuan Heng Lim, Jo Earn Bong, Valeria Villabona-Martinez, Carlos Cifuentes-González, Meenakshi Kumar, Srinivas Sadda, Leopold Schmetterer, Chui Ming Gemmy Cheung, Vishali Gupta, Dilraj S Grewal, Sharon Fekrat, Alejandra de-la-Torre, Bernett Lee, Xin Wei, Lisa Nivison-Smith, Rupesh Agrawal
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引用次数: 0

摘要

脉络膜血管指数(CVI)源于光学相干断层扫描(OCT),已成为检测血管变化的潜在生物标志物。了解其在生理状态、眼部状况和全身性疾病中的可变性对于其融入临床实践至关重要。与健康对照组相比,我们评估了不同生理状态(如妊娠早期)、眼部状况(如年龄相关性黄斑变性)和全身性疾病(如糖尿病)的CVI变化。从1210篇确定的文章中,63项研究(7316名受试者:4000名对照和3316例病例)符合纳入标准。数据涵盖了12种不同的条件和生理状态。大多数研究在欧洲和亚洲进行,主要使用低偏倚风险的光谱域OCT (SD-OCT)机器。在某些生理状态(如Valsalva动作、妊娠早期)和某些疾病(如活动性全葡萄膜炎、非活动性甲状腺眼病)中可见CVI升高。CVI降低见于糖尿病(伴或不伴糖尿病视网膜病变)、远视弱视和AMD。与健康对照相比,CVI显示了作为区分生理状态和病理状态的生物标志物的潜力。这些发现强调了脉络膜对系统和眼部挑战的适应性反应,强调了CVI在理解疾病机制和监测健康方面的相关性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Choroidal vascularity index as a marker of health and disease: systematic review and meta-analyses.

The Choroidal Vascularity Index (CVI), derived from optical coherence tomography (OCT), has emerged as a potential biomarker for detecting vascular changes. Understanding its variability across physiological states, ocular conditions, and systemic diseases is crucial for its integration into clinical practice. We evaluated variations in CVI across different physiological states (e.g., first-trimester pregnancy), ocular conditions (e.g., age-related macular degeneration[AMD]), and systemic diseases (e.g., diabetes mellitus) compared to healthy controls. From 1210 identified articles, 63 studies (7316 participants: 4000 controls and 3316 cases) met inclusion criteria. Data covered 12 distinct conditions and physiological states. Most studies were conducted in Europe and Asia, predominantly using spectral-domain OCT machines with a low risk of bias. Increased CVI was seen in some physiological states (e.g., Valsalva maneuver, first-trimester pregnancy) and some disorders (e.g. active panuveitis, inactive thyroid eye disease). Reduced CVI was found in diabetes mellitus (both with or without diabetic retinopathy), hyperopic amblyopia, and AMD. CVI demonstrates potential as a biomarker to differentiate between physiological states and pathological conditions compared to healthy controls. These findings underscore the choroid's adaptive response to systemic and ocular challenges, highlighting CVI's relevance in understanding disease mechanisms and monitoring health.

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来源期刊
Survey of ophthalmology
Survey of ophthalmology 医学-眼科学
CiteScore
10.30
自引率
2.00%
发文量
138
审稿时长
14.8 weeks
期刊介绍: Survey of Ophthalmology is a clinically oriented review journal designed to keep ophthalmologists up to date. Comprehensive major review articles, written by experts and stringently refereed, integrate the literature on subjects selected for their clinical importance. Survey also includes feature articles, section reviews, book reviews, and abstracts.
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