唐氏综合征和急性淋巴细胞白血病患者的烟雾综合征。

IF 2.3 3区医学 Q2 HEMATOLOGY

Pediatric Blood & Cancer Pub Date : 2025-09-07 DOI:10.1002/pbc.32045

Robert Lisac, Ryan J Summers, D John Bergsagel, Frank G Keller, Bryan Philbrook, David Wrubel, Gary Woods, Sunil S Raikar

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引用次数: 0

摘要

烟雾综合征（MMS）是一种以进行性脑内动脉狭窄为特征的慢性血管病变，导致卒中风险增加。患有唐氏综合症（DS）的儿童同时发生包括MMS和白血病在内的疾病的风险增加。我们报告了4例患有多发性硬化症、多发性硬化症和急性淋巴细胞白血病（ALL）的患者。两名患者在发展为ALL之前被诊断为MMS，而两名患者在ALL治疗期间被诊断为MMS。这一系列研究强调了对退行性椎体滑移和ALL患者MMS的认识，特别是对那些有急性神经系统改变的患者。

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Moyamoya Syndrome in Patients With Down Syndrome and Acute Lymphoblastic Leukemia.

Moyamoya syndrome (MMS) is a chronic vasculopathy characterized by progressive stenosis of intracerebral arteries, leading to an increased risk of stroke. Children with Down syndrome (DS) are at an increased risk of co-occurring medical conditions, including MMS and leukemia. We report four patients with the triad of DS, MMS, and acute lymphoblastic leukemia (ALL). Two patients had a diagnosis of MMS prior to developing ALL, whereas two were diagnosed with MMS during ALL therapy. This series highlights the need to remain cognizant of MMS in patients with DS and ALL, particularly in those with acute neurologic changes.

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来源期刊

Pediatric Blood & Cancer 医学-小儿科

CiteScore

4.90

自引率

9.40%

发文量

546

审稿时长

1.5 months

期刊介绍： Pediatric Blood & Cancer publishes the highest quality manuscripts describing basic and clinical investigations of blood disorders and malignant diseases of childhood including diagnosis, treatment, epidemiology, etiology, biology, and molecular and clinical genetics of these diseases as they affect children, adolescents, and young adults. Pediatric Blood & Cancer will also include studies on such treatment options as hematopoietic stem cell transplantation, immunology, and gene therapy.