{"title":"肉桂致接触性口炎74例回顾性分析并文献复习。","authors":"Eleni-Marina Kalogirou, Aikaterini Aktypi-Bampouranou, Marianna Vasilaki, Konstantina Chatzidimitriou, Konstantinos I Tosios","doi":"10.1111/odi.70081","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>Cinnamon-induced contact stomatitis (CCS) is a hypersensitivity reaction associated with cinnamon-containing products (CCPs). We performed a retrospective study of 74 cases of CCS induced by chewing gums or candies and reviewed the literature.</p><p><strong>Materials and methods: </strong>This is a retrospective study of CCS cases, diagnosed during 2010-2025, characterised by temporal association of lesions with the consumption of cinnamon-containing chewing gums or candies; lesion's resolution after discontinuation of those CCPs; and absence of recurrence as long as those CCPs were not re-used. The literature was reviewed for similar CCS cases, documented by relevant history and at least one clinical/histopathological image.</p><p><strong>Results: </strong>Seventy-four patients were diagnosed with CCS that mainly involved the buccal mucosa (67/74) and/or lateral tongue (50/74). White lichenoid or plaque-type lesions were observed in seven patients, erythematous/erosive/ulcerative lesions in 26 patients, and combined whitish-red lesions in 41 patients. Discontinuation of CCPs resulted in complete resolution within a week in all cases. The literature review yielded 40 well-documented cases of CCS related to chewing gums, candies, or mints.</p><p><strong>Conclusion: </strong>The presence of erythematous and/or white lesions at the occlusal plane should raise suspicion of CCS that can be diagnosed based on the patient's history and clinical presentation.</p>","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9000,"publicationDate":"2025-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Cinnamon-Induced Contact Stomatitis: A Retrospective Study of 74 Cases and Literature Review.\",\"authors\":\"Eleni-Marina Kalogirou, Aikaterini Aktypi-Bampouranou, Marianna Vasilaki, Konstantina Chatzidimitriou, Konstantinos I Tosios\",\"doi\":\"10.1111/odi.70081\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>Cinnamon-induced contact stomatitis (CCS) is a hypersensitivity reaction associated with cinnamon-containing products (CCPs). We performed a retrospective study of 74 cases of CCS induced by chewing gums or candies and reviewed the literature.</p><p><strong>Materials and methods: </strong>This is a retrospective study of CCS cases, diagnosed during 2010-2025, characterised by temporal association of lesions with the consumption of cinnamon-containing chewing gums or candies; lesion's resolution after discontinuation of those CCPs; and absence of recurrence as long as those CCPs were not re-used. The literature was reviewed for similar CCS cases, documented by relevant history and at least one clinical/histopathological image.</p><p><strong>Results: </strong>Seventy-four patients were diagnosed with CCS that mainly involved the buccal mucosa (67/74) and/or lateral tongue (50/74). White lichenoid or plaque-type lesions were observed in seven patients, erythematous/erosive/ulcerative lesions in 26 patients, and combined whitish-red lesions in 41 patients. Discontinuation of CCPs resulted in complete resolution within a week in all cases. The literature review yielded 40 well-documented cases of CCS related to chewing gums, candies, or mints.</p><p><strong>Conclusion: </strong>The presence of erythematous and/or white lesions at the occlusal plane should raise suspicion of CCS that can be diagnosed based on the patient's history and clinical presentation.</p>\",\"PeriodicalId\":19615,\"journal\":{\"name\":\"Oral diseases\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":2.9000,\"publicationDate\":\"2025-09-07\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Oral diseases\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1111/odi.70081\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"DENTISTRY, ORAL SURGERY & MEDICINE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Oral diseases","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1111/odi.70081","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"DENTISTRY, ORAL SURGERY & MEDICINE","Score":null,"Total":0}
Cinnamon-Induced Contact Stomatitis: A Retrospective Study of 74 Cases and Literature Review.
Objective: Cinnamon-induced contact stomatitis (CCS) is a hypersensitivity reaction associated with cinnamon-containing products (CCPs). We performed a retrospective study of 74 cases of CCS induced by chewing gums or candies and reviewed the literature.
Materials and methods: This is a retrospective study of CCS cases, diagnosed during 2010-2025, characterised by temporal association of lesions with the consumption of cinnamon-containing chewing gums or candies; lesion's resolution after discontinuation of those CCPs; and absence of recurrence as long as those CCPs were not re-used. The literature was reviewed for similar CCS cases, documented by relevant history and at least one clinical/histopathological image.
Results: Seventy-four patients were diagnosed with CCS that mainly involved the buccal mucosa (67/74) and/or lateral tongue (50/74). White lichenoid or plaque-type lesions were observed in seven patients, erythematous/erosive/ulcerative lesions in 26 patients, and combined whitish-red lesions in 41 patients. Discontinuation of CCPs resulted in complete resolution within a week in all cases. The literature review yielded 40 well-documented cases of CCS related to chewing gums, candies, or mints.
Conclusion: The presence of erythematous and/or white lesions at the occlusal plane should raise suspicion of CCS that can be diagnosed based on the patient's history and clinical presentation.
期刊介绍:
Oral Diseases is a multidisciplinary and international journal with a focus on head and neck disorders, edited by leaders in the field, Professor Giovanni Lodi (Editor-in-Chief, Milan, Italy), Professor Stefano Petti (Deputy Editor, Rome, Italy) and Associate Professor Gulshan Sunavala-Dossabhoy (Deputy Editor, Shreveport, LA, USA). The journal is pre-eminent in oral medicine. Oral Diseases specifically strives to link often-isolated areas of dentistry and medicine through broad-based scholarship that includes well-designed and controlled clinical research, analytical epidemiology, and the translation of basic science in pre-clinical studies. The journal typically publishes articles relevant to many related medical specialties including especially dermatology, gastroenterology, hematology, immunology, infectious diseases, neuropsychiatry, oncology and otolaryngology. The essential requirement is that all submitted research is hypothesis-driven, with significant positive and negative results both welcomed. Equal publication emphasis is placed on etiology, pathogenesis, diagnosis, prevention and treatment.