Mirvetuximab soravtansine在卵巢癌治疗领域:既往紫杉烷暴露对结果的影响。

IF 4.7 2区 医学 Q1 OBSTETRICS & GYNECOLOGY
Alexandra H Smick, Lindsay Brennan, Jordyn Silverstein, Ritu Salani, Gottfried Konecny, Dana M Chase
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引用次数: 0

摘要

目的:评价接受米维妥昔单抗治疗铂耐药卵巢癌患者的处方模式、毒性和结局。方法:本回顾性研究纳入了在单一机构(2018-2023)接受mirvetuximab治疗的高叶酸受体α表达的铂耐药卵巢癌患者。根据米维妥昔单抗治疗前的治疗情况对患者进行分类:紫杉烷组接受紫杉烷治疗;非紫杉烷组给予其他治疗。纳入年龄匹配的未接受mirvetuximab治疗的铂耐药患者进行生存比较。统计分析包括描述性统计、Kaplan-Meier曲线、log-rank检验、Wilcoxon秩和检验和Cox模型。结果:41例患者接受了mirvetuximab治疗,中位数为8个周期(范围:1-47)。≥3级不良事件包括眼部(n = 6; 15%)、血液学(n = 1; 2%)、神经病变(n = 1; 2%)和肺炎(n = 1; 2%)。剂量减少和延迟分别发生26例(63%)和21例(51%)患者。40例(98%)患者停用了Mirvetuximab,最常见的原因是疾病进展(n = 35; 88%)。与未使用mirvetuximab的年龄匹配队列相比,接受mirvetuximab治疗的患者从诊断开始的中位总生存期更长(83.12个月vs 52.14个月;HR 0.34, 95% CI 0.18 ~ 0.64, p < 0.001)。在mirvetuximab之前立即接受紫杉烷治疗的患者(n = 9),平均治疗时间为5个月(9个周期),无3级以上神经病变。在mirvetuximab之前立即接受非紫杉烷方案的患者(n = 32),平均治疗持续时间为6个月(8个周期),1例患者(3%)出现≥3级神经病变。两组间的中位无进展生存期相似(5.49个月vs 6.28个月;HR 1.30, 95% CI 0.61 ~ 2.78, p = 0.50),但紫杉烷组的总生存期较短(11.28个月vs 21.02个月;HR 2.47, 95% CI 1.01 ~ 6.04, p = 0.048)。结论:mirvetuximab在治疗铂耐药卵巢癌方面具有良好的安全性和临床获益。在mirvetuximab之前立即使用紫杉烷治疗与较短的总生存期相关,但不会增加神经毒性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Mirvetuximab soravtansine in the ovarian cancer treatment landscape: influence of prior taxane exposure on outcomes.

Objective: To evaluate prescribing patterns, toxicities, and outcomes among patients receiving mirvetuximab for platinum-resistant ovarian cancer.

Methods: This retrospective study included patients with platinum-resistant ovarian cancer with high folate receptor alpha expression treated with mirvetuximab at a single institution (2018-2023). Patients were categorized based on treatment immediately preceding mirvetuximab: the taxane group received taxane treatment; the non-taxane group received other therapy. An age-matched cohort of platinum-resistant patients not treated with mirvetuximab was included for survival comparison. Statistical analyses included descriptive statistics, Kaplan-Meier curves, log-rank tests, Wilcoxon rank-sum tests, and Cox models.

Results: Forty-one patients received mirvetuximab, with a median of 8 cycles (range; 1-47). Grade ≥3 adverse events included ocular (n = 6; 15%), hematologic (n = 1; 2%), neuropathy (n = 1; 2%), and pneumonitis (n = 1; 2%). Dose reductions and delays occurred in 26 (63%) and 21 (51%) patients, respectively. Mirvetuximab was discontinued in 40 patients (98%), most commonly due to disease progression (n = 35; 88%). Mirvetuximab-treated patients had longer median overall survival from diagnosis compared to the age-matched cohort without mirvetuximab exposure (83.12 vs 52.14 months; HR 0.34, 95% CI 0.18 to 0.64, p < .001). Among patients who received taxane therapy immediately before mirvetuximab (n = 9), average treatment duration was 5 months (9 cycles), with no grade ≥3 neuropathy. In those who received a non-taxane regimen immediately before mirvetuximab (n = 32), average treatment duration was 6 months (8 cycles), with 1 patient (3%) experiencing grade ≥3 neuropathy. Median progression-free survival was similar between groups (5.49 vs 6.28 months; HR 1.30, 95% CI 0.61 to 2.78, p = .50), but overall survival was shorter in the taxane group (11.28 vs 21.02 months; HR 2.47, 95% CI 1.01 to 6.04, p = .048).

Conclusions: Real-world experience with mirvetuximab demonstrated a favorable safety profile and clinical benefit in platinum-resistant ovarian cancer. Taxane therapy immediately preceding mirvetuximab was associated with shorter overall survival but not increased neurotoxicity.

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来源期刊
CiteScore
6.60
自引率
10.40%
发文量
280
审稿时长
3-6 weeks
期刊介绍: The International Journal of Gynecological Cancer, the official journal of the International Gynecologic Cancer Society and the European Society of Gynaecological Oncology, is the primary educational and informational publication for topics relevant to detection, prevention, diagnosis, and treatment of gynecologic malignancies. IJGC emphasizes a multidisciplinary approach, and includes original research, reviews, and video articles. The audience consists of gynecologists, medical oncologists, radiation oncologists, radiologists, pathologists, and research scientists with a special interest in gynecological oncology.
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