从常规血糖监测到持续血糖监测对口服降糖药物的2型糖尿病成人血糖控制和自我管理的影响

IF 7.4 3区医学 Q1 ENDOCRINOLOGY & METABOLISM

Diabetes research and clinical practice Pub Date : 2025-09-05 DOI:10.1016/j.diabres.2025.112458

Ayman Al Hayek , David C. Klonoff , Wael M. Al Zahrani , Abdulghani H. Al Saeed , Mohammed A. Al Dawish

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引用次数: 0

摘要

背景：尽管取得了进展，但口服降糖药物（ADMs）治疗2型糖尿病（PwT2D）患者的血糖控制通常仍不理想。连续血糖监测（CGM）在糖尿病管理中显示出前景，提供对血糖趋势的实时洞察。本研究评估了接受口服ADMs的PwT2D患者从传统的自我血糖监测（SMBG）转变为CGM对血糖结局和自我管理的影响。方法：在这项前瞻性研究中，纳入108名口服ADMs治疗的PwT2D患者。参与者从传统的SMBG过渡到FreeStyle Libre 2 CGM系统，为期12 周。在基线和研究终点记录临床、代谢和血糖参数，以及通过血糖监测自我管理量表（IGMSS）评估的患者报告的结果。结果：CGM的使用与多项血糖和自我管理指标的显著改善相关。在12 周内，HbA1c从7.93 %降至7.31 % （p ）。结论：口服ADMs治疗的PwT2D患者，从传统SMBG切换到CGM可显著改善血糖控制和自我管理。这一观察结果突出了CGM在这一人群中更广泛整合的潜力。

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Impact of transitioning from conventional blood glucose monitoring to continuous glucose monitoring on glycemic control and self-management in adults with type 2 diabetes on oral glucose-lowering medications

Background

Despite advances, glycemic control in people with type 2 diabetes (PwT2D) treated with oral antidiabetic medications (ADMs) often remains suboptimal. Continuous glucose monitoring (CGM) has shown promise in diabetes management, offering real-time insights into glucose trends. This study evaluates the impact of transitioning from conventional self-monitoring of blood glucose (SMBG) to CGM on glycemic outcomes and self-management in PwT2D receiving oral ADMs.

Methods

In this prospective study, 108 PwT2D managed with oral ADMs were enrolled. Participants transitioned from conventional SMBG to the FreeStyle Libre 2 CGM system for 12 weeks. Clinical, metabolic, and glycemic parameters, alongside patient-reported outcomes assessed by the Impact of Glucose Monitoring on Self-Management Scale (IGMSS), were recorded at baseline and study endpoint.

Results

CGM use was associated with significant improvement across multiple glycemic and self-management metrics. Over 12 weeks, HbA1c decreased from 7.93 % to 7.31 % (p < 0.001), and mean capillary glucose levels decreased from 191 mg/dL to 180 mg/dL (p < 0.001). Time in range reached 70 % (SD = 6.86). Self-management, as measured by the IGMSS, improved—with Capability scores rising from 16.1 to 30.3, Opportunity from 19.8 to 35, and Motivation from 12.3 to 23.3 (all p < 0.001). The scale score increased from 42 to 75.6 (p < 0.001). Additionally, longer diabetes duration (p = 0.024) and more frequent SMBG (p = 0.012) were associated with lower endpoint IGMSS scores, whereas the presence of co-morbidities was linked to higher scores (p = 0.03).

Conclusion

Switching from conventional SMBG to CGM significantly improved glycemic control and self-management in PwT2D treated with oral ADMs. This observation highlights the potential for broader integration of CGM into this population.

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来源期刊

Diabetes research and clinical practice 医学-内分泌学与代谢

CiteScore

10.30

自引率

3.90%

发文量

862

审稿时长

32 days

期刊介绍： Diabetes Research and Clinical Practice is an international journal for health-care providers and clinically oriented researchers that publishes high-quality original research articles and expert reviews in diabetes and related areas. The role of the journal is to provide a venue for dissemination of knowledge and discussion of topics related to diabetes clinical research and patient care. Topics of focus include translational science, genetics, immunology, nutrition, psychosocial research, epidemiology, prevention, socio-economic research, complications, new treatments, technologies and therapy.