Michael L. Alosco, Madeline Morrison, Rhoda Au, Eric G. Steinberg, Jane Mwicigi, Monica Ly, Caroline Altaras, Steve Lenio, Myriam Abdennadher, Maureen K. O'Connor, Yorghos Tripodis, Joseph Palmisano, Diane Dixon, Brett Martin, Greta Schneider, Jenna R. Groh, Andrew Ellison, Dean Sheppard, Chad W. Farris, Christopher Nowinski, Robert C. Cantu, Katherine W. Turk, Lindsay Farrer, Gyungah Jun, Lee E. Goldstein, Wei Qiao Qiu, Thor D. Stein, Andrew E. Budson, Ann C. McKee, Jesse Mez
{"title":"波士顿大学阿尔茨海默病研究中心临床核心：促进创伤后阿尔茨海默病和相关痴呆研究的基础设施","authors":"Michael L. Alosco, Madeline Morrison, Rhoda Au, Eric G. Steinberg, Jane Mwicigi, Monica Ly, Caroline Altaras, Steve Lenio, Myriam Abdennadher, Maureen K. O'Connor, Yorghos Tripodis, Joseph Palmisano, Diane Dixon, Brett Martin, Greta Schneider, Jenna R. Groh, Andrew Ellison, Dean Sheppard, Chad W. Farris, Christopher Nowinski, Robert C. Cantu, Katherine W. Turk, Lindsay Farrer, Gyungah Jun, Lee E. Goldstein, Wei Qiao Qiu, Thor D. Stein, Andrew E. Budson, Ann C. McKee, Jesse Mez","doi":"10.1002/alz.70654","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <p>We describe the rationale, methodology, and design of the Boston University Alzheimer's Disease Research Center (BU ADRC) Clinical Core (CC). The CC characterizes a longitudinal cohort of participants with/without brain trauma to characterize the clinical presentation, biomarker profiles, and risk factors of post-traumatic Alzheimer's disease (AD) and AD-related dementias (ADRD), including chronic traumatic encephalopathy (CTE). Participants complete assessments of traumatic brain injury (TBI) and repetitive head impacts (RHIs); annual Uniform Data Set (UDS) and supplementary evaluations; digital phenotyping; annual blood draw; magnetic resonance imaging (MRI) and lumbar puncture every 3 years; electroencephalogram (EEG); and amyloid and/or tau positron emission tomography (PET) on a subset. As of 3/2025, the CC consists of 467 participants (mean age: 65.6, 50.1% female), including 163 RHI and 302 TBI who completed a UDS 3.0 baseline visit. Common sources of RHI included football (<i>n</i> = 95), soccer (<i>n</i> = 26), ice hockey (<i>n</i> = 17), and military service (<i>n</i> = 46). Most TBIs were mild (97.7%). Eighty-nine percent agreed to brain donation. The BU ADRC CC will facilitate research, education, and training on post-traumatic AD/ADRD.</p>\n </section>\n \n <section>\n \n <h3> Highlights</h3>\n \n <div>\n <ul>\n \n <li>The Boston University Alzheimer's Disease Research Center (ADRC) Clinical Core facilitates unique research, education, and training on Alzheimer's disease and Alzheimer's disease-related dementias (AD/ADRD) with a focus on post-traumatic AD/ADRD, including chronic traumatic encephalopathy (CTE).</li>\n \n <li>We summarize the rationale, mission, study design, and recent updates for the Clinical Core.</li>\n \n <li>As of March 2025, the Clinical Core includes a longitudinal cohort of 467 participants enriched for repetitive head impacts (∼1/3) and traumatic brain injury (∼1/3) exposure who span the cognitive continuum, with most having available fluid and neuroimaging biomarker data and agreeing to brain donation (89%).</li>\n </ul>\n </div>\n </section>\n </div>","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"21 9","pages":""},"PeriodicalIF":11.1000,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://alz-journals.onlinelibrary.wiley.com/doi/epdf/10.1002/alz.70654","citationCount":"0","resultStr":"{\"title\":\"Boston University Alzheimer's Disease Research Center Clinical Core: Infrastructure to facilitate research on post-traumatic Alzheimer's disease and related dementias\",\"authors\":\"Michael L. 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The CC characterizes a longitudinal cohort of participants with/without brain trauma to characterize the clinical presentation, biomarker profiles, and risk factors of post-traumatic Alzheimer's disease (AD) and AD-related dementias (ADRD), including chronic traumatic encephalopathy (CTE). Participants complete assessments of traumatic brain injury (TBI) and repetitive head impacts (RHIs); annual Uniform Data Set (UDS) and supplementary evaluations; digital phenotyping; annual blood draw; magnetic resonance imaging (MRI) and lumbar puncture every 3 years; electroencephalogram (EEG); and amyloid and/or tau positron emission tomography (PET) on a subset. As of 3/2025, the CC consists of 467 participants (mean age: 65.6, 50.1% female), including 163 RHI and 302 TBI who completed a UDS 3.0 baseline visit. Common sources of RHI included football (<i>n</i> = 95), soccer (<i>n</i> = 26), ice hockey (<i>n</i> = 17), and military service (<i>n</i> = 46). Most TBIs were mild (97.7%). Eighty-nine percent agreed to brain donation. 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Boston University Alzheimer's Disease Research Center Clinical Core: Infrastructure to facilitate research on post-traumatic Alzheimer's disease and related dementias
We describe the rationale, methodology, and design of the Boston University Alzheimer's Disease Research Center (BU ADRC) Clinical Core (CC). The CC characterizes a longitudinal cohort of participants with/without brain trauma to characterize the clinical presentation, biomarker profiles, and risk factors of post-traumatic Alzheimer's disease (AD) and AD-related dementias (ADRD), including chronic traumatic encephalopathy (CTE). Participants complete assessments of traumatic brain injury (TBI) and repetitive head impacts (RHIs); annual Uniform Data Set (UDS) and supplementary evaluations; digital phenotyping; annual blood draw; magnetic resonance imaging (MRI) and lumbar puncture every 3 years; electroencephalogram (EEG); and amyloid and/or tau positron emission tomography (PET) on a subset. As of 3/2025, the CC consists of 467 participants (mean age: 65.6, 50.1% female), including 163 RHI and 302 TBI who completed a UDS 3.0 baseline visit. Common sources of RHI included football (n = 95), soccer (n = 26), ice hockey (n = 17), and military service (n = 46). Most TBIs were mild (97.7%). Eighty-nine percent agreed to brain donation. The BU ADRC CC will facilitate research, education, and training on post-traumatic AD/ADRD.
Highlights
The Boston University Alzheimer's Disease Research Center (ADRC) Clinical Core facilitates unique research, education, and training on Alzheimer's disease and Alzheimer's disease-related dementias (AD/ADRD) with a focus on post-traumatic AD/ADRD, including chronic traumatic encephalopathy (CTE).
We summarize the rationale, mission, study design, and recent updates for the Clinical Core.
As of March 2025, the Clinical Core includes a longitudinal cohort of 467 participants enriched for repetitive head impacts (∼1/3) and traumatic brain injury (∼1/3) exposure who span the cognitive continuum, with most having available fluid and neuroimaging biomarker data and agreeing to brain donation (89%).
期刊介绍：
Alzheimer's & Dementia is a peer-reviewed journal that aims to bridge knowledge gaps in dementia research by covering the entire spectrum, from basic science to clinical trials to social and behavioral investigations. It provides a platform for rapid communication of new findings and ideas, optimal translation of research into practical applications, increasing knowledge across diverse disciplines for early detection, diagnosis, and intervention, and identifying promising new research directions. In July 2008, Alzheimer's & Dementia was accepted for indexing by MEDLINE, recognizing its scientific merit and contribution to Alzheimer's research.
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