{"title":"二线策略治疗抑郁症比剂量优化更有效","authors":"","doi":"10.1002/pu.31358","DOIUrl":null,"url":null,"abstract":"<p>Alternative second-line treatments for major depressive disorder led to higher response and remission rates in comparison to commonly used dose optimization in a randomized trial. The combination of a selective serotonin reuptake inhibitor (SSRI) and psychotherapy resulted in the lowest prevalence of adverse events among the studied second-line strategies.</p>","PeriodicalId":22275,"journal":{"name":"The Brown University Psychopharmacology Update","volume":"36 10","pages":"3-4"},"PeriodicalIF":0.0000,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Second-line strategies more effective than dose optimization in depression treatment\",\"authors\":\"\",\"doi\":\"10.1002/pu.31358\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>Alternative second-line treatments for major depressive disorder led to higher response and remission rates in comparison to commonly used dose optimization in a randomized trial. The combination of a selective serotonin reuptake inhibitor (SSRI) and psychotherapy resulted in the lowest prevalence of adverse events among the studied second-line strategies.</p>\",\"PeriodicalId\":22275,\"journal\":{\"name\":\"The Brown University Psychopharmacology Update\",\"volume\":\"36 10\",\"pages\":\"3-4\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-09-09\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The Brown University Psychopharmacology Update\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/pu.31358\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Brown University Psychopharmacology Update","FirstCategoryId":"1085","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/pu.31358","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Second-line strategies more effective than dose optimization in depression treatment
Alternative second-line treatments for major depressive disorder led to higher response and remission rates in comparison to commonly used dose optimization in a randomized trial. The combination of a selective serotonin reuptake inhibitor (SSRI) and psychotherapy resulted in the lowest prevalence of adverse events among the studied second-line strategies.
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