生物活性重组人弹性蛋白凝胶,用于重建弹性纤维和恢复内源性老化皮肤

IF 10.2 1区 医学 Q1 ENGINEERING, BIOMEDICAL
Yi Yang , Wenjie Huang , Jingjing Shi , Bei Tian , Caihong Fu , Jianxi Xiao
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引用次数: 0

摘要

内源性皮肤老化导致氧化应激和弹性纤维降解,导致皮肤弹性降低,皮肤松弛。目前的治疗很少针对弹性纤维再生。在这里,我们介绍了一种含有重组人源化弹性蛋白(RHE)的生物活性凝胶,它能有效地恢复皮肤弹性,促进细胞外基质重塑。RHE凝胶在斑马鱼模型中显示出逆转紫外线诱导的损伤和氧化应激的卓越功效,并显著改善老年小鼠的皮肤功能,优于商业维生素E和重组人源胶原(RHC)凝胶。分子分析显示,关键弹性纤维和胶原成分的表达增强,基质降解酶减少。这项研究突出了RHE凝胶作为再生皮肤病和皮肤老化的新疗法的潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Bioactive recombinant human elastin gel for reconstructing elastic fibers and rejuvenating endogenously aged skin

Bioactive recombinant human elastin gel for reconstructing elastic fibers and rejuvenating endogenously aged skin
Endogenous skin aging results in oxidative stress and degradation of elastic fibers, leading to reduced skin elasticity and dermal laxity. Current treatments rarely target elastic fiber regeneration. Here, we introduce a bioactive gel containing recombinant humanized elastin (RHE) that effectively restores skin elasticity and promotes extracellular matrix remodeling. RHE gel demonstrated superior efficacy in reversing UV-induced damage and oxidative stress in zebrafish models, and significantly improved skin function in aged mice, outperforming commercial vitamin E and recombinant humanized collagen (RHC) gels. Molecular analyses revealed enhanced expression of key elastic fiber and collagen components alongside reduced matrix-degrading enzymes. This study highlights RHE gel's potential as a novel therapeutic for regenerative dermatology and skin aging.
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来源期刊
CiteScore
8.30
自引率
4.90%
发文量
303
审稿时长
30 days
期刊介绍: Materials Today Bio is a multidisciplinary journal that specializes in the intersection between biology and materials science, chemistry, physics, engineering, and medicine. It covers various aspects such as the design and assembly of new structures, their interaction with biological systems, functionalization, bioimaging, therapies, and diagnostics in healthcare. The journal aims to showcase the most significant advancements and discoveries in this field. As part of the Materials Today family, Materials Today Bio provides rigorous peer review, quick decision-making, and high visibility for authors. It is indexed in Scopus, PubMed Central, Emerging Sources, Citation Index (ESCI), and Directory of Open Access Journals (DOAJ).
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