中暑引起的中枢神经系统损伤：机制和治疗观点

IF 2.9 2区生物学 Q2 BIOLOGY

Journal of thermal biology Pub Date : 2025-08-01 DOI:10.1016/j.jtherbio.2025.104263

Wenjun Yang , Zhen Gao , Chengjin Wang , Min Wang , Yuan Cao , Yun Li , Shaoqing Shi , Yiqi Wu , Lu Wang , Hongjun Kang

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引用次数: 0

摘要

中暑（HS）是一种危及生命的热相关疾病，其特征是核心体温迅速升高超过40℃，并伴有中枢神经系统（CNS）功能障碍和多器官功能障碍综合征（MODS）。随着全球气候变暖的影响不断加剧，HS发病率逐步上升，对全球健康构成重大威胁。中枢神经系统是HS的主要靶器官之一，其损伤机制涉及炎症级联反应、氧化应激、程序性细胞死亡和血脑屏障（BBB）破坏等复杂的相互作用。这些病理过程协同作用导致神经元损伤、功能障碍、潜在的长期认知和运动缺陷。本文综述了目前关于hs诱导的中枢神经系统损伤的分子和细胞机制的证据，探讨了目前治疗策略的进展，并提出了未来的研究方向以解决关键的知识空白。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Heat stroke-induced central nervous system injury: Mechanisms and therapeutic perspectives

Heat stroke (HS), a life-threatening heat-related disorder, is characterized by a rapid elevation of core body temperature exceeding 40 °C, accompanied by central nervous system (CNS) dysfunction and multiple organ dysfunction syndrome (MODS). With the escalating impact of global warming, the incidence of HS has risen progressively, posing a significant threat to global health. The CNS is one of the primary target organs in HS, and its injury mechanisms involve intricate interactions among inflammatory cascades, oxidative stress, programmed cell death, and blood-brain barrier (BBB) disruption. These pathological processes synergistically contribute to neuronal damage, functional impairment, potential long-term cognitive and motor deficits. This review synthesizes current evidence on the molecular and cellular mechanisms underlying HS-induced CNS injury, explores the current progress in therapeutic strategies, and proposes future research directions to address critical knowledge gaps.

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来源期刊

Journal of thermal biology 生物-动物学

CiteScore

5.30

自引率

7.40%

发文量

196

审稿时长

14.5 weeks

期刊介绍： The Journal of Thermal Biology publishes articles that advance our knowledge on the ways and mechanisms through which temperature affects man and animals. This includes studies of their responses to these effects and on the ecological consequences. Directly relevant to this theme are: • The mechanisms of thermal limitation, heat and cold injury, and the resistance of organisms to extremes of temperature • The mechanisms involved in acclimation, acclimatization and evolutionary adaptation to temperature • Mechanisms underlying the patterns of hibernation, torpor, dormancy, aestivation and diapause • Effects of temperature on reproduction and development, growth, ageing and life-span • Studies on modelling heat transfer between organisms and their environment • The contributions of temperature to effects of climate change on animal species and man • Studies of conservation biology and physiology related to temperature • Behavioural and physiological regulation of body temperature including its pathophysiology and fever • Medical applications of hypo- and hyperthermia Article types: • Original articles • Review articles