Wei Sang , Haoliang Fan , Yijun Huang , Junfeng Zhang , Weiqi Gao , Chaoran Zhao , Xiaoyao Liu , Linmei Zhao , Yulong Liu , Yunlu Dai , Ruiping Zhang
{"title":"纳米材料辅助超声诊断和治疗肿瘤的新策略","authors":"Wei Sang , Haoliang Fan , Yijun Huang , Junfeng Zhang , Weiqi Gao , Chaoran Zhao , Xiaoyao Liu , Linmei Zhao , Yulong Liu , Yunlu Dai , Ruiping Zhang","doi":"10.1016/j.ultsonch.2025.107542","DOIUrl":null,"url":null,"abstract":"<div><div>With the development of nanomedicine and ultrasound technology, ultrasound-enhanced contrast agents and treatment platforms based on nanomaterials have become important tools for tumor diagnosis and treatment, owing to their high safety profile, low cost and excellent biocompatibility. This review comprehensively discusses the classification and mechanism of nanomaterials in enhancing ultrasound imaging and treatment. It encompasses organic nanomaterials, including nanobubbles and polymer nanoparticles, and as well as inorganic nanomaterials, such as metal nanoparticles and metal oxide nanoparticles. The application strategies and typical examples of combining nanomaterials with ultrasound technology for different tumors are elaborated, including brain tumors, breast cancer, lung cancer, liver cancer and pancreatic cancer. Numerous studies have demonstrated that integrating ultrasound technology with nano-delivery systems can improve drug delivery efficiency and overcome physiological barriers. This integration can also enhance anti-tumor effects by modulating the tumor immune microenvironment. Despite the significant progress in this field, challenges regarding the biosafety and clinical translation of nanomaterials remain. Future research should concentrate on optimizing the design of nanomaterials and strengthening clinical studies. This will promote the widespread application of ultrasound and nanotechnology in tumor treatment.</div></div>","PeriodicalId":442,"journal":{"name":"Ultrasonics Sonochemistry","volume":"121 ","pages":"Article 107542"},"PeriodicalIF":9.7000,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"New strategies for tumor diagnosis and therapy with ultrasound assisted by nanomaterials\",\"authors\":\"Wei Sang , Haoliang Fan , Yijun Huang , Junfeng Zhang , Weiqi Gao , Chaoran Zhao , Xiaoyao Liu , Linmei Zhao , Yulong Liu , Yunlu Dai , Ruiping Zhang\",\"doi\":\"10.1016/j.ultsonch.2025.107542\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>With the development of nanomedicine and ultrasound technology, ultrasound-enhanced contrast agents and treatment platforms based on nanomaterials have become important tools for tumor diagnosis and treatment, owing to their high safety profile, low cost and excellent biocompatibility. This review comprehensively discusses the classification and mechanism of nanomaterials in enhancing ultrasound imaging and treatment. It encompasses organic nanomaterials, including nanobubbles and polymer nanoparticles, and as well as inorganic nanomaterials, such as metal nanoparticles and metal oxide nanoparticles. The application strategies and typical examples of combining nanomaterials with ultrasound technology for different tumors are elaborated, including brain tumors, breast cancer, lung cancer, liver cancer and pancreatic cancer. Numerous studies have demonstrated that integrating ultrasound technology with nano-delivery systems can improve drug delivery efficiency and overcome physiological barriers. This integration can also enhance anti-tumor effects by modulating the tumor immune microenvironment. Despite the significant progress in this field, challenges regarding the biosafety and clinical translation of nanomaterials remain. Future research should concentrate on optimizing the design of nanomaterials and strengthening clinical studies. This will promote the widespread application of ultrasound and nanotechnology in tumor treatment.</div></div>\",\"PeriodicalId\":442,\"journal\":{\"name\":\"Ultrasonics Sonochemistry\",\"volume\":\"121 \",\"pages\":\"Article 107542\"},\"PeriodicalIF\":9.7000,\"publicationDate\":\"2025-09-05\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Ultrasonics Sonochemistry\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1350417725003219\",\"RegionNum\":1,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"ACOUSTICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Ultrasonics Sonochemistry","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1350417725003219","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ACOUSTICS","Score":null,"Total":0}
New strategies for tumor diagnosis and therapy with ultrasound assisted by nanomaterials
With the development of nanomedicine and ultrasound technology, ultrasound-enhanced contrast agents and treatment platforms based on nanomaterials have become important tools for tumor diagnosis and treatment, owing to their high safety profile, low cost and excellent biocompatibility. This review comprehensively discusses the classification and mechanism of nanomaterials in enhancing ultrasound imaging and treatment. It encompasses organic nanomaterials, including nanobubbles and polymer nanoparticles, and as well as inorganic nanomaterials, such as metal nanoparticles and metal oxide nanoparticles. The application strategies and typical examples of combining nanomaterials with ultrasound technology for different tumors are elaborated, including brain tumors, breast cancer, lung cancer, liver cancer and pancreatic cancer. Numerous studies have demonstrated that integrating ultrasound technology with nano-delivery systems can improve drug delivery efficiency and overcome physiological barriers. This integration can also enhance anti-tumor effects by modulating the tumor immune microenvironment. Despite the significant progress in this field, challenges regarding the biosafety and clinical translation of nanomaterials remain. Future research should concentrate on optimizing the design of nanomaterials and strengthening clinical studies. This will promote the widespread application of ultrasound and nanotechnology in tumor treatment.
期刊介绍:
Ultrasonics Sonochemistry stands as a premier international journal dedicated to the publication of high-quality research articles primarily focusing on chemical reactions and reactors induced by ultrasonic waves, known as sonochemistry. Beyond chemical reactions, the journal also welcomes contributions related to cavitation-induced events and processing, including sonoluminescence, and the transformation of materials on chemical, physical, and biological levels.
Since its inception in 1994, Ultrasonics Sonochemistry has consistently maintained a top ranking in the "Acoustics" category, reflecting its esteemed reputation in the field. The journal publishes exceptional papers covering various areas of ultrasonics and sonochemistry. Its contributions are highly regarded by both academia and industry stakeholders, demonstrating its relevance and impact in advancing research and innovation.