变形杆菌的分类，临床意义，和高度通用病原体的抗生素耐药性。

IF 19.3 1区医学 Q1 MICROBIOLOGY

Clinical Microbiology Reviews Pub Date : 2025-09-08 DOI:10.1128/cmr.00181-24

Linea Katharina Muhsal,Lisa Theis,Jörg Overmann,Axel Hamprecht

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引用次数: 0

摘要

变形杆菌属肠杆菌目，广泛存在于人类、动物和环境中。有些菌种，特别是奇异假单胞菌，具有高致病性，是引起尿路和血液感染的最常见原因之一。变形杆菌具有多种毒力因子，如群体和脲酶活性，导致持续和严重的感染。据报道，菌株对抗生素的耐药性日益增强，并对全球健康构成重大威胁。近年来，已经发现了几种新的变形杆菌属，但它们作为病原体的潜力尚未确定。在这里，我们提供了最新的分类，毒力因子，和抗生素耐药性的变形杆菌。

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Proteus spp.-taxonomy, clinical significance, and antibiotic resistance of a highly versatile pathogen.

SUMMARYProteus spp. are members of the Enterobacterales order and are widely found in humans, animals, and the environment. Some species, particularly P. mirabilis, are highly pathogenic and are among the most frequent causes of urinary tract and bloodstream infections. Proteus spp. possess a variety of virulence factors, such as swarming and urease activity, leading to persistent and severe infections. An increasing resistance to antibiotics has been reported for isolates and poses a substantial threat to global health. In recent years, several new Proteus spp. have been described, but their potential as pathogens has not yet been determined. Here, we provide an update on the taxonomy, virulence factors, and antibiotic resistance of Proteus spp.

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来源期刊

Clinical Microbiology Reviews 医学-微生物学

CiteScore

54.20

自引率

0.50%

发文量

期刊介绍： Clinical Microbiology Reviews (CMR) is a journal that primarily focuses on clinical microbiology and immunology.It aims to provide readers with up-to-date information on the latest developments in these fields.CMR also presents the current state of knowledge in clinical microbiology and immunology.Additionally, the journal offers balanced and thought-provoking perspectives on controversial issues in these areas.