表皮免疫微环境中皮肤微生物组和抗菌肽之间的相互作用：对特应性皮炎的桥接见解。

IF 6.7 2区医学 Q1 ALLERGY

Allergology International Pub Date : 2025-09-05 DOI:10.1016/j.alit.2025.08.002

Shan Wang, Ge Peng, Alafate Abudouwanli, Mengyao Yang, Quan Sun, Wanchen Zhao, Arisa Ikeda, Yi Tan, Lin Ma, Hideoki Ogawa, Ko Okumura, François Niyonsaba

{"title":"表皮免疫微环境中皮肤微生物组和抗菌肽之间的相互作用：对特应性皮炎的桥接见解。","authors":"Shan Wang, Ge Peng, Alafate Abudouwanli, Mengyao Yang, Quan Sun, Wanchen Zhao, Arisa Ikeda, Yi Tan, Lin Ma, Hideoki Ogawa, Ko Okumura, François Niyonsaba","doi":"10.1016/j.alit.2025.08.002","DOIUrl":null,"url":null,"abstract":"The epidermal immune microenvironment is a multifaceted system in which the interplay between the skin microbiome and antimicrobial peptides plays a pivotal role in sustaining skin homeostasis and preventing dysbiosis. Disruption of these interactions can lead to inflammatory skin conditions such as atopic dermatitis. This review aims to explore the complex mechanisms by which antimicrobial peptides and the skin microbiome communicate within the epidermal immune microenvironment, emphasizing causal dynamics and the dual role of antimicrobial peptides. This analysis opens new avenues for targeted interventions, including antimicrobial peptide modulation and microbiome-based therapies, to restore skin health and mitigate inflammatory skin disorders.","PeriodicalId":48861,"journal":{"name":"Allergology International","volume":" ","pages":""},"PeriodicalIF":6.7000,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The interaction between the skin microbiome and antimicrobial peptides within the epidermal immune microenvironment: Bridging insights into atopic dermatitis.\",\"authors\":\"Shan Wang, Ge Peng, Alafate Abudouwanli, Mengyao Yang, Quan Sun, Wanchen Zhao, Arisa Ikeda, Yi Tan, Lin Ma, Hideoki Ogawa, Ko Okumura, François Niyonsaba\",\"doi\":\"10.1016/j.alit.2025.08.002\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The epidermal immune microenvironment is a multifaceted system in which the interplay between the skin microbiome and antimicrobial peptides plays a pivotal role in sustaining skin homeostasis and preventing dysbiosis. Disruption of these interactions can lead to inflammatory skin conditions such as atopic dermatitis. This review aims to explore the complex mechanisms by which antimicrobial peptides and the skin microbiome communicate within the epidermal immune microenvironment, emphasizing causal dynamics and the dual role of antimicrobial peptides. This analysis opens new avenues for targeted interventions, including antimicrobial peptide modulation and microbiome-based therapies, to restore skin health and mitigate inflammatory skin disorders.\",\"PeriodicalId\":48861,\"journal\":{\"name\":\"Allergology International\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":6.7000,\"publicationDate\":\"2025-09-05\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Allergology International\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1016/j.alit.2025.08.002\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"ALLERGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Allergology International","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.alit.2025.08.002","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ALLERGY","Score":null,"Total":0}

引用次数: 0

摘要

表皮免疫微环境是一个多方面的系统，其中皮肤微生物群和抗菌肽之间的相互作用在维持皮肤稳态和防止生态失调中起着关键作用。这些相互作用的破坏可导致炎症性皮肤状况，如特应性皮炎。本文旨在探讨抗菌肽和皮肤微生物群在表皮免疫微环境中相互作用的复杂机制，强调抗菌肽的因果动力学和双重作用。这一分析为有针对性的干预开辟了新的途径，包括抗菌肽调节和基于微生物组的治疗，以恢复皮肤健康和减轻炎症性皮肤疾病。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

The interaction between the skin microbiome and antimicrobial peptides within the epidermal immune microenvironment: Bridging insights into atopic dermatitis.

The epidermal immune microenvironment is a multifaceted system in which the interplay between the skin microbiome and antimicrobial peptides plays a pivotal role in sustaining skin homeostasis and preventing dysbiosis. Disruption of these interactions can lead to inflammatory skin conditions such as atopic dermatitis. This review aims to explore the complex mechanisms by which antimicrobial peptides and the skin microbiome communicate within the epidermal immune microenvironment, emphasizing causal dynamics and the dual role of antimicrobial peptides. This analysis opens new avenues for targeted interventions, including antimicrobial peptide modulation and microbiome-based therapies, to restore skin health and mitigate inflammatory skin disorders.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Allergology International ALLERGY-IMMUNOLOGY

CiteScore

12.60

自引率

5.90%

发文量

审稿时长

29 weeks

期刊介绍： Allergology International is the official journal of the Japanese Society of Allergology and publishes original papers dealing with the etiology, diagnosis and treatment of allergic and related diseases. Papers may include the study of methods of controlling allergic reactions, human and animal models of hypersensitivity and other aspects of basic and applied clinical allergy in its broadest sense. The Journal aims to encourage the international exchange of results and encourages authors from all countries to submit papers in the following three categories: Original Articles, Review Articles, and Letters to the Editor.