使用基线光学相干断层扫描生物标志物预测视网膜静脉闭塞的治疗反应:系统综述。

IF 5.9 2区 医学 Q1 OPHTHALMOLOGY
Amin Hatamnejad, Keean Nanji, Justin Grad, Abdullah El-Sayes, Andrew Mihalache, Mohamed Gemae, Ryan Huang, Nadia K Waheed, David Sarraf, SrinVas R Sadda, Tien Yin Wong, Dena Zeraatkar, Jinhiu Ma, Sunir J Garg, Marion R Munk, Enrico Borrelli, David H Steel, Sobha Sivaprasad, Charles C Wykoff, Varun Chaudhary
{"title":"使用基线光学相干断层扫描生物标志物预测视网膜静脉闭塞的治疗反应:系统综述。","authors":"Amin Hatamnejad, Keean Nanji, Justin Grad, Abdullah El-Sayes, Andrew Mihalache, Mohamed Gemae, Ryan Huang, Nadia K Waheed, David Sarraf, SrinVas R Sadda, Tien Yin Wong, Dena Zeraatkar, Jinhiu Ma, Sunir J Garg, Marion R Munk, Enrico Borrelli, David H Steel, Sobha Sivaprasad, Charles C Wykoff, Varun Chaudhary","doi":"10.1016/j.survophthal.2025.08.016","DOIUrl":null,"url":null,"abstract":"<p><p>This systematic review examines the prognostic value of baseline optical coherence tomography (OCT) biomarkers in predicting visual acuity (VA) outcomes for eyes with macular edema secondary to retinal vein occlusions (RVO) treated with anti-VEGF therapies, steroids, laser photocoagulation, or combination treatments. VA predictions at 6, 12, and 24 months post-treatment were assessed using a narrative synthesis approach and vote counting based on effect direction relative to a minimal clinically important difference. Certainty of evidence was evaluated using GRADE guidelines. Confounding factors, biomarker variability, and inconsistent outcome measurements were critically analyzed. A total of 116 studies assessing 31 unique OCT biomarkers were included. 'Low' certainty evidence indicated that an intact external limiting membrane (ELM) at baseline predicted better VA at 6 months, while baseline ellipsoid zone (EZ) integrity predicted better VA at 12 months at 5-letter change, however, these associations were not observed at thresholds of 10 and 15 letters. Certainty of evidence was often downgraded due to confounding factors, variability in biomarker definitions, and inconsistent outcomes. These findings highlight OCT biomarkers' potential for prognostication in RVO patients, but underscore the need for standardized definitions and further research to address confounders, improving the reliability and clinical utility of OCT-based biomarkers.</p>","PeriodicalId":22102,"journal":{"name":"Survey of ophthalmology","volume":" ","pages":""},"PeriodicalIF":5.9000,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Predicting treatment response in retinal vein occlusions using baseline optical coherence tomography biomarkers: A systematic review.\",\"authors\":\"Amin Hatamnejad, Keean Nanji, Justin Grad, Abdullah El-Sayes, Andrew Mihalache, Mohamed Gemae, Ryan Huang, Nadia K Waheed, David Sarraf, SrinVas R Sadda, Tien Yin Wong, Dena Zeraatkar, Jinhiu Ma, Sunir J Garg, Marion R Munk, Enrico Borrelli, David H Steel, Sobha Sivaprasad, Charles C Wykoff, Varun Chaudhary\",\"doi\":\"10.1016/j.survophthal.2025.08.016\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>This systematic review examines the prognostic value of baseline optical coherence tomography (OCT) biomarkers in predicting visual acuity (VA) outcomes for eyes with macular edema secondary to retinal vein occlusions (RVO) treated with anti-VEGF therapies, steroids, laser photocoagulation, or combination treatments. VA predictions at 6, 12, and 24 months post-treatment were assessed using a narrative synthesis approach and vote counting based on effect direction relative to a minimal clinically important difference. Certainty of evidence was evaluated using GRADE guidelines. Confounding factors, biomarker variability, and inconsistent outcome measurements were critically analyzed. A total of 116 studies assessing 31 unique OCT biomarkers were included. 'Low' certainty evidence indicated that an intact external limiting membrane (ELM) at baseline predicted better VA at 6 months, while baseline ellipsoid zone (EZ) integrity predicted better VA at 12 months at 5-letter change, however, these associations were not observed at thresholds of 10 and 15 letters. Certainty of evidence was often downgraded due to confounding factors, variability in biomarker definitions, and inconsistent outcomes. These findings highlight OCT biomarkers' potential for prognostication in RVO patients, but underscore the need for standardized definitions and further research to address confounders, improving the reliability and clinical utility of OCT-based biomarkers.</p>\",\"PeriodicalId\":22102,\"journal\":{\"name\":\"Survey of ophthalmology\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":5.9000,\"publicationDate\":\"2025-09-04\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Survey of ophthalmology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1016/j.survophthal.2025.08.016\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"OPHTHALMOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Survey of ophthalmology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.survophthal.2025.08.016","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"OPHTHALMOLOGY","Score":null,"Total":0}
引用次数: 0

摘要

本系统综述探讨了基线光学相干断层扫描(OCT)生物标志物在预测接受抗vegf治疗、类固醇、激光光凝或联合治疗的视网膜静脉闭塞(RVO)继发黄斑水肿患者视力(VA)结果方面的预后价值。治疗后6个月、12个月和24个月的VA预测使用叙事综合方法和基于相对于最小临床重要差异的效果方向的投票计数进行评估。使用GRADE指南评估证据的确定性。对混杂因素、生物标志物可变性和不一致的结果测量进行了严格分析。共纳入116项研究,评估31种独特的OCT生物标志物。“低”确定性证据表明,基线时完整的外限制膜(ELM)预测6个月时更好的VA,而基线椭球区(EZ)完整性预测12个月时5个字母变化时更好的VA,然而,在阈值为10和15个字母时未观察到这些关联。由于混杂因素、生物标志物定义的可变性和不一致的结果,证据的确定性经常被降低。这些发现强调了OCT生物标志物在RVO患者中的预后潜力,但也强调了标准化定义和进一步研究的必要性,以解决混杂因素,提高基于OCT的生物标志物的可靠性和临床实用性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Predicting treatment response in retinal vein occlusions using baseline optical coherence tomography biomarkers: A systematic review.

This systematic review examines the prognostic value of baseline optical coherence tomography (OCT) biomarkers in predicting visual acuity (VA) outcomes for eyes with macular edema secondary to retinal vein occlusions (RVO) treated with anti-VEGF therapies, steroids, laser photocoagulation, or combination treatments. VA predictions at 6, 12, and 24 months post-treatment were assessed using a narrative synthesis approach and vote counting based on effect direction relative to a minimal clinically important difference. Certainty of evidence was evaluated using GRADE guidelines. Confounding factors, biomarker variability, and inconsistent outcome measurements were critically analyzed. A total of 116 studies assessing 31 unique OCT biomarkers were included. 'Low' certainty evidence indicated that an intact external limiting membrane (ELM) at baseline predicted better VA at 6 months, while baseline ellipsoid zone (EZ) integrity predicted better VA at 12 months at 5-letter change, however, these associations were not observed at thresholds of 10 and 15 letters. Certainty of evidence was often downgraded due to confounding factors, variability in biomarker definitions, and inconsistent outcomes. These findings highlight OCT biomarkers' potential for prognostication in RVO patients, but underscore the need for standardized definitions and further research to address confounders, improving the reliability and clinical utility of OCT-based biomarkers.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Survey of ophthalmology
Survey of ophthalmology 医学-眼科学
CiteScore
10.30
自引率
2.00%
发文量
138
审稿时长
14.8 weeks
期刊介绍: Survey of Ophthalmology is a clinically oriented review journal designed to keep ophthalmologists up to date. Comprehensive major review articles, written by experts and stringently refereed, integrate the literature on subjects selected for their clinical importance. Survey also includes feature articles, section reviews, book reviews, and abstracts.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信