剖析眼底镶嵌的临床和病理生理复杂性。

IF 5.9 2区 医学 Q1 OPHTHALMOLOGY
Ramesh Venkatesh, Pratibha Hande, Vishma Prabhu, Shruthi Vidyasagar, Karishma Tendulkar, Rupak Roy, Kanika Godani, Alisha Sirsikar, Preksha Biradar, Priyanka Gandhi, Naresh Kumar Yadav, Jay Chhablani
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引用次数: 0

摘要

眼底镶嵌(FT),也被称为斑状或马赛克眼底,其特征是眼底脉络膜血管的可见性增加。虽然通常是生理上的发现,但FT也可能是高度近视、脉络膜萎缩或色素紊乱等疾病的早期病理信号。我们综合了目前对影响FT外观的解剖学、光学和成像因素的理解,包括轴向伸长、黑色素分布和介质清晰度的作用。多模态成像技术的进步,如彩色眼底摄影、光学相干断层扫描和眼底自身荧光,提高了区分生理性FT和疾病相关变化的能力。此外,眼底镶嵌密度指数(FTDI)等人工智能驱动的工具为临床决策提供了定量支持。我们提出一个结合临床参数、影像特征和FTDI的结构化框架来指导诊断和风险评估。我们强调了准确区分生理性和病理性FT的临床意义,并强调了未来的研究方向,包括FTDI作为预后生物标志物的潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Dissecting the clinical and pathophysiological complexity of fundus tessellation.

Fundus tessellation (FT)-also referred to as tigroid or mosaic fundus-is characterized by increased visibility of underlying choroidal vessels. While often a physiological finding, FT may also signal early pathology in conditions such as high myopia, choroidal atrophy, or pigmentary disorders. We synthesize current understanding of the anatomical, optical, and imaging factors influencing FT appearance, including the roles of axial elongation, melanin distribution, and media clarity. Advances in multimodal imaging-such as color fundus photography, optical coherence tomography, and fundus autofluorescence-have improved the ability to differentiate physiological FT from disease-associated changes. Furthermore, artificial intelligence-driven tools like the Fundus Tessellation Density Index (FTDI) provide quantitative support for clinical decision-making. We propose a structured framework combining clinical parameters, imaging features, and FTDI to guide diagnosis and risk assessment. We underscore the clinical relevance of accurately distinguishing physiological from pathological FT and highlights directions for future research, including the potential of FTDI as a prognostic biomarker.

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来源期刊
Survey of ophthalmology
Survey of ophthalmology 医学-眼科学
CiteScore
10.30
自引率
2.00%
发文量
138
审稿时长
14.8 weeks
期刊介绍: Survey of Ophthalmology is a clinically oriented review journal designed to keep ophthalmologists up to date. Comprehensive major review articles, written by experts and stringently refereed, integrate the literature on subjects selected for their clinical importance. Survey also includes feature articles, section reviews, book reviews, and abstracts.
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