定量光诱导荧光技术在早期龋病检测及树脂浸润治疗中的应用。

IF 5.5 2区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of dentistry Pub Date : 2025-09-04 DOI:10.1016/j.jdent.2025.106086

Yangyang Shi , Xue Feng , Mingyun Li , Xiao Guo , Haohao Wang , Dongyue Dai , Jinzhi He , Lei Cheng

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引用次数: 0

摘要

目的：本研究旨在探讨定量光诱导荧光（QLF）在早期龋病检测和治疗中的具体应用场景，为QLF的临床应用提供更多依据。方法：(1)采用横向显微放射成像（TMR）和分光光度计分析相结合的方法，评价QLF检测早期龋病深度的准确性（n=6）。(2)采用树脂浸润疗法作为早期龋病治疗的代表性方法，评价QLF对早期龋病治疗效果的评价能力（n=6）。(3)对治疗后早期龋进行再脱矿，评价QLF对深部病变的检测能力（n=6）。结果：在早期龋检中，当脱矿深度< 200µm时，QLF和分光光度计分析均准确，且与TMR结果相关性较好（r=-0.9938, r=-0.9534, p < 0.05）。QLF和分光光度计检测均能有效反映树脂浸润治疗后早期龋的治疗效果。然而，当浸润性树脂治疗的早期龋齿进行再脱矿治疗，病灶深度为bbb200µm时，QLF对再脱矿早期龋齿的诊断准确性明显下降，不如TMR和分光光度计分析准确。结论：当脱矿深度小于200µm时，QLF可用于早期龋的检测和早期龋的治疗效果评价。但对于树脂浸润处理后超过200 μm的深部再脱矿病变，QLF不适合检测。临床意义：早期龋病的及时诊断和治疗在临床上非常重要。探讨QLF在早期龋病检测和治疗中的具体适用性，有助于为其临床应用提供更多依据，对龋病的防治具有重要意义。

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Application of quantitative light-induced fluorescence technology in early caries detection and resin infiltration treatment

Objectives

The aim of this study is to explore the specific application scenarios of quantitative light-induced fluorescence (QLF) in detecting early caries before and after treatment, so as to provide more evidence for the clinical application of QLF.

Methods

(1) The accuracy of QLF in detecting the lesion depth of early caries was evaluated by combining transverse microradiography (TMR) and spectrophotometer analysis (n = 6). (2) Resin infiltration therapy was used as a representative method for the treatment of early caries to evaluate the ability of QLF in assessing the therapeutic effect on early caries (n = 6). (3) Re-demineralization of early caries after treatment was performed to evaluate the detection capability of QLF for deeper lesions (n = 6).

Results

In the detection of early caries, when the demineralization depth was <200 µm, both QLF and spectrophotometer analysis were accurate and correlated well with TMR results (r=-0.9938, r=0.9776, p < 0.05). In addition, both QLF and spectrophotometer detection could effectively reflect the therapeutic effect on early caries after resin infiltration treatment. However, when the early caries treated with infiltrative resin were re-demineralized and the lesion depth > 200 µm, the diagnostic accuracy of QLF for the re-demineralized early caries decreased significantly, which was not as precise as TMR and spectrophotometer analysis.

Conclusion

When the demineralization depth is <200 µm, QLF can be used to detect early caries and evaluate the therapeutic effect on early caries. However, QLF is not suitable for detecting deep re-demineralized lesions exceeds 200 μm after resin infiltration treatment.

Clinical significance

Timely diagnosis and treatment of early caries are very important in clinic. Exploring the specific applicability of QLF in detecting early caries before and after treatment is helpful to provide more evidence for its clinical application, which is of great significance for the prevention and treatment of caries.

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来源期刊

Journal of dentistry 医学-牙科与口腔外科

CiteScore

7.30

自引率

11.40%

发文量

349

审稿时长

35 days

期刊介绍： The Journal of Dentistry has an open access mirror journal The Journal of Dentistry: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. The Journal of Dentistry is the leading international dental journal within the field of Restorative Dentistry. Placing an emphasis on publishing novel and high-quality research papers, the Journal aims to influence the practice of dentistry at clinician, research, industry and policy-maker level on an international basis. Topics covered include the management of dental disease, periodontology, endodontology, operative dentistry, fixed and removable prosthodontics, dental biomaterials science, long-term clinical trials including epidemiology and oral health, technology transfer of new scientific instrumentation or procedures, as well as clinically relevant oral biology and translational research. The Journal of Dentistry will publish original scientific research papers including short communications. It is also interested in publishing review articles and leaders in themed areas which will be linked to new scientific research. Conference proceedings are also welcome and expressions of interest should be communicated to the Editor.