Roux-en-Y胃旁路术后相位角下降反映体重减轻期间液体再分配：一项12个月的随访研究

Q2 Medicine

Obesity Medicine Pub Date : 2025-09-01 DOI:10.1016/j.obmed.2025.100644

Beatriz Bobbio de Brito , João Arthur Souza Fiorido , Doglas Gobbi Marchesi , Luís Carlos Lopes Júnior , Luciane Bresciani Salaroli , Blanca Elena Guerrero Daboin , Andressa Bolsoni Lopes , Fabiano Kenji Haraguchi

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引用次数: 0

摘要

AimsPhase角（PhA）是细胞完整性和液体平衡的指标，在严重肥胖患者中，特别是在术后减肥期间，尚未得到充分研究。本研究评估了Roux-en-Y胃旁路术（RYGB）后12个月的PhA轨迹及其体成分决定因素。方法60名符合纳入标准的参与者在四个时间点进行评估：手术前，RYGB后2、6和12个月。在每次随访中评估体成分和PhA。采用Friedman检验（α = 0.05）检验随时间的变化。Spearman相关和多元线性回归探讨了PhA与身体成分变量之间的关系。结果术后spha显著下降，且在所有术后评估中均与细胞外/细胞内水（ECW:ICW）比呈一致的负相关（p < 0.05）。体重、BMI、腰围、脂肪量、无脂肪量和全身水分也有显著降低（p < 0.05）。结论ECW:ICW比值是PhA下降的主要决定因素，反映了快速减肥过程中体液再分配和早期代谢适应。PhA可作为监测减肥手术生理反应的实用标记物。

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Phase angle decline after Roux-en-Y gastric bypass reflects fluid redistribution during the weight loss: A 12-month follow-up study

Aims

Phase angle (PhA), an indicator of cellular integrity and fluid balance, is underexplored in individuals with severe obesity, particularly during postoperative weight loss. This study evaluated PhA trajectories and their body composition determinants over 12 months following Roux-en-Y gastric bypass (RYGB).

Methods

Sixty participants meeting inclusion criteria were assessed at four time points: before surgery, and at 2, 6, and 12 months after RYGB. Body composition and PhA were evaluated at each follow-up. The Friedman test (α = 0.05) was used to examine changes over time. Spearman's correlation and multiple linear regression explored associations between PhA and body composition variables.

Results

PhA declined significantly after surgery and showed a consistent inverse association with the extracellular to intracellular water (ECW:ICW) ratio at all postoperative assessments (p < 0.05). Significant reductions were also observed in weight, BMI, waist circumference, fat mass, fat-free mass, and total body water (p < 0.05).

Conclusion

The ECW:ICW ratio was the primary determinant of PhA decline, reflecting fluid redistribution and early metabolic adaptation during rapid weight loss. PhA may serve as a practical marker for monitoring physiological responses to bariatric surgery.

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来源期刊

Obesity Medicine Medicine-Public Health, Environmental and Occupational Health

CiteScore

5.50

自引率

0.00%

发文量

审稿时长

40 days

期刊介绍： The official journal of the Shanghai Diabetes Institute Obesity is a disease of increasing global prevalence with serious effects on both the individual and society. Obesity Medicine focusses on health and disease, relating to the very broad spectrum of research in and impacting on humans. It is an interdisciplinary journal that addresses mechanisms of disease, epidemiology and co-morbidities. Obesity Medicine encompasses medical, societal, socioeconomic as well as preventive aspects of obesity and is aimed at researchers, practitioners and educators alike.