老年人腹主动脉瘤破裂的结局和谁应该提供手术

IF 2.4 3区 医学 Q1 PERIPHERAL VASCULAR DISEASE
Colby Meinke, Kristina A. Giles
{"title":"老年人腹主动脉瘤破裂的结局和谁应该提供手术","authors":"Colby Meinke,&nbsp;Kristina A. Giles","doi":"10.1053/j.semvascsurg.2025.07.007","DOIUrl":null,"url":null,"abstract":"<div><div>As life expectancy increases, the prevalence of ruptured abdominal aortic aneurysms (rAAA) poses a significant challenge for our healthcare system. Aging induces biochemical changes, including degradation of the extracellular matrix and loss of vascular smooth muscle cells, which increase the propensity for the development of aneurysms and subsequent rupture due to compromised integrity of the aortic wall. The mortality rate for elderly patients presenting with rAAA is high, ranging from 80 to 90%. Both open and endovascular repair come with substantial risk for elderly patients. While EVAR has been shown to have lower perioperative mortality in this population, elderly patients face significant post-operative recovery challenges related to age and frailty. In determining who should be offered surgery for rAAA, patient selection is crucial. Frailty and existing comorbidities should be factored into whether or not patients are offered surgery. A tailored approach that is individualized to patient specific goals and accounts for pre-existing comorbidities and functional status is essential to improving outcomes for elderly patients presenting with rAAA.</div></div>","PeriodicalId":51153,"journal":{"name":"Seminars in Vascular Surgery","volume":"38 3","pages":"Pages 243-249"},"PeriodicalIF":2.4000,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Outcomes of ruptured abdominal aortic aneurysms in older adults and who should be offered surgery\",\"authors\":\"Colby Meinke,&nbsp;Kristina A. Giles\",\"doi\":\"10.1053/j.semvascsurg.2025.07.007\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>As life expectancy increases, the prevalence of ruptured abdominal aortic aneurysms (rAAA) poses a significant challenge for our healthcare system. Aging induces biochemical changes, including degradation of the extracellular matrix and loss of vascular smooth muscle cells, which increase the propensity for the development of aneurysms and subsequent rupture due to compromised integrity of the aortic wall. The mortality rate for elderly patients presenting with rAAA is high, ranging from 80 to 90%. Both open and endovascular repair come with substantial risk for elderly patients. While EVAR has been shown to have lower perioperative mortality in this population, elderly patients face significant post-operative recovery challenges related to age and frailty. In determining who should be offered surgery for rAAA, patient selection is crucial. Frailty and existing comorbidities should be factored into whether or not patients are offered surgery. A tailored approach that is individualized to patient specific goals and accounts for pre-existing comorbidities and functional status is essential to improving outcomes for elderly patients presenting with rAAA.</div></div>\",\"PeriodicalId\":51153,\"journal\":{\"name\":\"Seminars in Vascular Surgery\",\"volume\":\"38 3\",\"pages\":\"Pages 243-249\"},\"PeriodicalIF\":2.4000,\"publicationDate\":\"2025-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Seminars in Vascular Surgery\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0895796725000560\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"PERIPHERAL VASCULAR DISEASE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Seminars in Vascular Surgery","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0895796725000560","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PERIPHERAL VASCULAR DISEASE","Score":null,"Total":0}
引用次数: 0

摘要

随着预期寿命的增加,腹主动脉瘤破裂(rAAA)的患病率对我们的医疗保健系统提出了重大挑战。衰老引起生物化学变化,包括细胞外基质的降解和血管平滑肌细胞的丧失,这增加了动脉瘤发展的倾向,并由于主动脉壁完整性受损而导致随后的破裂。老年rAAA患者的死亡率很高,从80%到90%不等。对于老年患者,开放和血管内修复都有很大的风险。虽然EVAR已被证明在这一人群中具有较低的围手术期死亡率,但老年患者面临着与年龄和虚弱相关的重大术后恢复挑战。在决定谁应该接受rAAA手术时,患者的选择是至关重要的。患者是否接受手术应考虑到虚弱和现有的合并症。针对患者的具体目标,考虑已有的合并症和功能状态,量身定制的方法对于改善老年rAAA患者的预后至关重要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Outcomes of ruptured abdominal aortic aneurysms in older adults and who should be offered surgery
As life expectancy increases, the prevalence of ruptured abdominal aortic aneurysms (rAAA) poses a significant challenge for our healthcare system. Aging induces biochemical changes, including degradation of the extracellular matrix and loss of vascular smooth muscle cells, which increase the propensity for the development of aneurysms and subsequent rupture due to compromised integrity of the aortic wall. The mortality rate for elderly patients presenting with rAAA is high, ranging from 80 to 90%. Both open and endovascular repair come with substantial risk for elderly patients. While EVAR has been shown to have lower perioperative mortality in this population, elderly patients face significant post-operative recovery challenges related to age and frailty. In determining who should be offered surgery for rAAA, patient selection is crucial. Frailty and existing comorbidities should be factored into whether or not patients are offered surgery. A tailored approach that is individualized to patient specific goals and accounts for pre-existing comorbidities and functional status is essential to improving outcomes for elderly patients presenting with rAAA.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
CiteScore
3.50
自引率
4.00%
发文量
54
审稿时长
50 days
期刊介绍: Each issue of Seminars in Vascular Surgery examines the latest thinking on a particular clinical problem and features new diagnostic and operative techniques. The journal allows practitioners to expand their capabilities and to keep pace with the most rapidly evolving areas of surgery.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信