类风湿关节炎患者抗鲤鱼水平与临床活性和血清学特征的关系

Pablo Martínez Calabuig , Elena Grau García , José Andrés Román Ivorra
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引用次数: 0

摘要

目的分析类风湿关节炎(RA)患者抗鲤鱼水平与临床活性、表现及血清学特征的关系。方法横断面研究包括RA患者和健康对照(HC)。收集临床及分析资料,ELISA检测抗鲤鱼水平。结果共纳入101例患者(女性79%,平均年龄45岁),98例HC患者(女性67%,平均年龄55岁)。RA患者的抗鲤鱼水平明显高于HC (p < 0.001),且随年龄增长而升高(p = 0.004)。Anti-CarP与RF和ACPA阳性相关(p < 0.001)。与其他组相比,RF/ACPA阳性患者的抗鲤鱼水平最高(p < 0.001)。anti-CarP升高阈值设为17.2 ng/mL。35例抗鲤鱼升高患者中,32例为RF/ACPA双阳性(p = 0.006), 3例为血清阴性。抗鲤鱼水平升高与临床活动、关节压痛(p = 0.002)、类风湿结节和间质性肺疾病的存在相关,但与Sharp/van der Heijde评分、关节损伤进展或Sjögren综合征无关。结论ra患者具有较高的抗鲤鱼水平,尤其是RF/ACPA双阳性患者。升高的水平与较高的疾病活动度和关节外受累相关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Association of anti-CarP levels with clinical activity and serological profile in rheumatoid arthritis

Objective

To analyze the association of anti-CarP levels with clinical activity, manifestations, and serological profile in rheumatoid arthritis (RA) patients.

Methods

Cross-sectional study including RA patients and healthy controls (HC). Clinical and analytical data were collected, and anti-CarP levels were measured by ELISA.

Results

A total of 101 patients (79% female, mean age 45), and 98 HC (67% female, mean age 55) were included. RA patients had significantly higher anti-CarP levels than HC (p < 0.001), increasing with age (p = 0.004). Anti-CarP correlated with RF and ACPA positivity (p < 0.001). Those patients with RF/ACPA positive showed the highest anti-CarP levels compared to other groups (p < 0.001).
The threshold for elevated anti-CarP was set at 17.2 ng/mL. Among 35 patients with elevated anti-CarP, 32 were RF/ACPA double-positive (p = 0.006), and 3 were seronegative. Elevated anti-CarP levels were associated to clinical activity, tender joints (p = 0.002), the presence of rheumatoid nodules and interstitial lung disease, but not with Sharp/van der Heijde score, joint damage progression or Sjögren syndrome.

Conclusions

RA patients exhibit higher anti-CarP levels, especially those with RF/ACPA double-positivity. Elevated levels correlate with higher disease activity and extra-articular involvement.
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