Pablo Martínez Calabuig , Elena Grau García , José Andrés Román Ivorra
{"title":"类风湿关节炎患者抗鲤鱼水平与临床活性和血清学特征的关系","authors":"Pablo Martínez Calabuig , Elena Grau García , José Andrés Román Ivorra","doi":"10.1016/j.medcle.2025.107045","DOIUrl":null,"url":null,"abstract":"<div><h3>Objective</h3><div>To analyze the association of anti-CarP levels with clinical activity, manifestations, and serological profile in rheumatoid arthritis (RA) patients.</div></div><div><h3>Methods</h3><div>Cross-sectional study including RA patients and healthy controls (HC). Clinical and analytical data were collected, and anti-CarP levels were measured by ELISA.</div></div><div><h3>Results</h3><div>A total of 101 patients (79% female, mean age 45), and 98 HC (67% female, mean age 55) were included. RA patients had significantly higher anti-CarP levels than HC (<em>p</em> <!--><<!--> <!-->0.001), increasing with age (<em>p</em> <!-->=<!--> <!-->0.004). Anti-CarP correlated with RF and ACPA positivity (<em>p</em> <!--><<!--> <!-->0.001). Those patients with RF/ACPA positive showed the highest anti-CarP levels compared to other groups (<em>p</em> <!--><<!--> <!-->0.001).</div><div>The threshold for elevated anti-CarP was set at 17.2<!--> <!-->ng/mL. Among 35 patients with elevated anti-CarP, 32 were RF/ACPA double-positive (<em>p</em> <!-->=<!--> <!-->0.006), and 3 were seronegative. Elevated anti-CarP levels were associated to clinical activity, tender joints (<em>p</em> <!-->=<!--> <!-->0.002), the presence of rheumatoid nodules and interstitial lung disease, but not with Sharp/van der Heijde score, joint damage progression or Sjögren syndrome.</div></div><div><h3>Conclusions</h3><div>RA patients exhibit higher anti-CarP levels, especially those with RF/ACPA double-positivity. Elevated levels correlate with higher disease activity and extra-articular involvement.</div></div>","PeriodicalId":74154,"journal":{"name":"Medicina clinica (English ed.)","volume":"165 3","pages":"Article 107045"},"PeriodicalIF":0.0000,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Association of anti-CarP levels with clinical activity and serological profile in rheumatoid arthritis\",\"authors\":\"Pablo Martínez Calabuig , Elena Grau García , José Andrés Román Ivorra\",\"doi\":\"10.1016/j.medcle.2025.107045\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Objective</h3><div>To analyze the association of anti-CarP levels with clinical activity, manifestations, and serological profile in rheumatoid arthritis (RA) patients.</div></div><div><h3>Methods</h3><div>Cross-sectional study including RA patients and healthy controls (HC). Clinical and analytical data were collected, and anti-CarP levels were measured by ELISA.</div></div><div><h3>Results</h3><div>A total of 101 patients (79% female, mean age 45), and 98 HC (67% female, mean age 55) were included. RA patients had significantly higher anti-CarP levels than HC (<em>p</em> <!--><<!--> <!-->0.001), increasing with age (<em>p</em> <!-->=<!--> <!-->0.004). Anti-CarP correlated with RF and ACPA positivity (<em>p</em> <!--><<!--> <!-->0.001). Those patients with RF/ACPA positive showed the highest anti-CarP levels compared to other groups (<em>p</em> <!--><<!--> <!-->0.001).</div><div>The threshold for elevated anti-CarP was set at 17.2<!--> <!-->ng/mL. Among 35 patients with elevated anti-CarP, 32 were RF/ACPA double-positive (<em>p</em> <!-->=<!--> <!-->0.006), and 3 were seronegative. Elevated anti-CarP levels were associated to clinical activity, tender joints (<em>p</em> <!-->=<!--> <!-->0.002), the presence of rheumatoid nodules and interstitial lung disease, but not with Sharp/van der Heijde score, joint damage progression or Sjögren syndrome.</div></div><div><h3>Conclusions</h3><div>RA patients exhibit higher anti-CarP levels, especially those with RF/ACPA double-positivity. Elevated levels correlate with higher disease activity and extra-articular involvement.</div></div>\",\"PeriodicalId\":74154,\"journal\":{\"name\":\"Medicina clinica (English ed.)\",\"volume\":\"165 3\",\"pages\":\"Article 107045\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Medicina clinica (English ed.)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2387020625004413\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Medicina clinica (English ed.)","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2387020625004413","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Association of anti-CarP levels with clinical activity and serological profile in rheumatoid arthritis
Objective
To analyze the association of anti-CarP levels with clinical activity, manifestations, and serological profile in rheumatoid arthritis (RA) patients.
Methods
Cross-sectional study including RA patients and healthy controls (HC). Clinical and analytical data were collected, and anti-CarP levels were measured by ELISA.
Results
A total of 101 patients (79% female, mean age 45), and 98 HC (67% female, mean age 55) were included. RA patients had significantly higher anti-CarP levels than HC (p < 0.001), increasing with age (p = 0.004). Anti-CarP correlated with RF and ACPA positivity (p < 0.001). Those patients with RF/ACPA positive showed the highest anti-CarP levels compared to other groups (p < 0.001).
The threshold for elevated anti-CarP was set at 17.2 ng/mL. Among 35 patients with elevated anti-CarP, 32 were RF/ACPA double-positive (p = 0.006), and 3 were seronegative. Elevated anti-CarP levels were associated to clinical activity, tender joints (p = 0.002), the presence of rheumatoid nodules and interstitial lung disease, but not with Sharp/van der Heijde score, joint damage progression or Sjögren syndrome.
Conclusions
RA patients exhibit higher anti-CarP levels, especially those with RF/ACPA double-positivity. Elevated levels correlate with higher disease activity and extra-articular involvement.