伊莉莎白菌引起的感染性心内膜炎：2例报告并文献复习

IF 4 3区医学 Q1 INFECTIOUS DISEASES

Journal of Infection and Public Health Pub Date : 2025-09-04 DOI:10.1016/j.jiph.2025.102968

Valentin Colin , Brice Guerpillon , Mathieu Blot , Lionel Piroth , Lucie Amoureux , Jean Philippe Talarmin , Thibault Sixt

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引用次数: 0

摘要

我们报告两例伊丽莎白相关的感染性心内膜炎，突出了关键的危险因素，如人工瓣膜置换术。这些病例强调需要考虑心内膜炎在设置持续或复发菌血症。诊断证明具有挑战性，需要多种成像方式，当超声心动图无贡献时，正电子发射断层扫描（PET）扫描提供了临界值。在治疗过程中，由于机体固有的多药耐药和快速出现的额外耐药，治疗变得复杂。这些病例强调了联合抗生素治疗方案的重要性，其中二甲胺四环素可能起关键作用。由于其能够迅速粘附并在假体瓣膜上产生生物膜，我们的病例支持早期手术干预以消除生物膜并限制进一步的耐药性发展的必要性。为了更好地描述这种罕见的实体，我们对先前报道的病例进行了文献回顾，这加强了与伊丽莎白心内膜炎相关的诊断和治疗挑战。

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Infectious endocarditis caused by Elizabethkingia spp.: Two case reports and a literature review

We report two cases of Elizabethkingia-related infective endocarditis, highlighting key risk factors such as prosthetic valve replacement. These cases underscore the need to consider endocarditis in the setting of persistent or recurrent bacteremia.

Diagnosis proved challenging and required multiple imaging modalities, with positron emission tomography (PET) scan providing critical value when echocardiography was non-contributory. Management was complicated by the organism’s intrinsic multidrug resistance and the rapid emergence of additional resistance during therapy. These cases emphasize the importance of combination antibiotic regimens, in which minocycline may play a key role.

Due to its ability to rapidly adhere to and produce biofilm on prosthetic valves, our cases support the need for early surgical intervention to eradicate the biofilm and limit further resistance development. To better characterize this rare entity, we conducted a literature review of previously reported cases, which reinforces the diagnostic and therapeutic challenges associated with Elizabethkingia endocarditis.

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来源期刊

Journal of Infection and Public Health PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH -INFECTIOUS DISEASES

CiteScore

13.10

自引率

1.50%

发文量

203

审稿时长

96 days

期刊介绍： The Journal of Infection and Public Health, first official journal of the Saudi Arabian Ministry of National Guard Health Affairs, King Saud Bin Abdulaziz University for Health Sciences and the Saudi Association for Public Health, aims to be the foremost scientific, peer-reviewed journal encompassing infection prevention and control, microbiology, infectious diseases, public health and the application of healthcare epidemiology to the evaluation of health outcomes. The point of view of the journal is that infection and public health are closely intertwined and that advances in one area will have positive consequences on the other. The journal will be useful to all health professionals who are partners in the management of patients with communicable diseases, keeping them up to date. The journal is proud to have an international and diverse editorial board that will assist and facilitate the publication of articles that reflect a global view on infection control and public health, as well as emphasizing our focus on supporting the needs of public health practitioners. It is our aim to improve healthcare by reducing risk of infection and related adverse outcomes by critical review, selection, and dissemination of new and relevant information in the field of infection control, public health and infectious diseases in all healthcare settings and the community.