解码斑马鱼的卵发生：从原始生殖细胞发育到受精

IF 6 2区生物学 Q1 CELL BIOLOGY

Seminars in cell & developmental biology Pub Date : 2025-09-05 DOI:10.1016/j.semcdb.2025.103650

Laura Hofmann, Carl-Philipp Heisenberg

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引用次数: 0

摘要

卵发生-卵母细胞的形成和发育-是生殖和胚胎发育的基础。由于其易于遗传操作和体外培养和实验操作卵母细胞的能力，斑马鱼已成为研究卵子发生的强大脊椎动物模型系统。在这篇综述中，我们提供了斑马鱼卵发生的全面概述，从早期生殖细胞形成到卵母细胞成熟和受精。我们讨论了在揭示驱动这一复杂过程的分子和细胞机制方面的最新进展，并强调了仍有待解决的关键知识空白。

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Decoding zebrafish oogenesis: From primordial germ cell development to fertilization

Oogenesis – the formation and development of an oocyte – is fundamental to reproduction and embryonic development. Due to its accessibility to genetic manipulations and the ability to culture and experimentally manipulate oocytes ex vivo, zebrafish has emerged as a powerful vertebrate model system for studying oogenesis. In this review, we provide a comprehensive overview of zebrafish oogenesis, from early germ cell formation to oocyte maturation and fertilization. We discuss recent advances in uncovering the molecular and cellular mechanisms driving this complex process and highlight key knowledge gaps that remain to be addressed.

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来源期刊

Seminars in cell & developmental biology 生物-发育生物学

CiteScore

15.10

自引率

1.40%

发文量

310

审稿时长

9.1 weeks

期刊介绍： Seminars in Cell and Developmental Biology is a review journal dedicated to keeping scientists informed of developments in the field of molecular cell and developmental biology, on a topic by topic basis. Each issue is thematic in approach, devoted to an important topic of interest to cell and developmental biologists, focusing on the latest advances and their specific implications. The aim of each issue is to provide a coordinated, readable, and lively review of a selected area, published rapidly to ensure currency.