{"title":"环状RNA：从非编码调节因子到功能性蛋白质编码器","authors":"Xinwei Zhang , Hongyan Wu , Xuechuan Hong , Yuling Xiao , Xiaodong Zeng","doi":"10.1016/j.pscia.2025.100085","DOIUrl":null,"url":null,"abstract":"<div><div>Circular RNAs (circRNAs), a distinct class of non-coding RNAs characterized by a covalently closed circular structure, have gained prominence as a promising research field due to their unique biological properties and functional roles relative to linear RNAs. This review summarizes recent progress in circRNA research, emphasizing fundamental mechanisms and translational potential. We first outline the discovery, biological features, synthesis, and purification of circRNAs. Next, their delivery systems, biological functions, and applications are reviewed. Finally, we discuss challenges and future prospects for clinical translation, with a focus on advancing precision medicine, gene therapy, and personalized vaccines. This review uniquely integrates recent advances in circRNA biology with their translational applications, offering a comprehensive perspective from molecular mechanisms to clinical potential.</div></div>","PeriodicalId":101012,"journal":{"name":"Pharmaceutical Science Advances","volume":"3 ","pages":"Article 100085"},"PeriodicalIF":0.0000,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Circular RNA: From non-coding regulators to functional protein encoders\",\"authors\":\"Xinwei Zhang , Hongyan Wu , Xuechuan Hong , Yuling Xiao , Xiaodong Zeng\",\"doi\":\"10.1016/j.pscia.2025.100085\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Circular RNAs (circRNAs), a distinct class of non-coding RNAs characterized by a covalently closed circular structure, have gained prominence as a promising research field due to their unique biological properties and functional roles relative to linear RNAs. This review summarizes recent progress in circRNA research, emphasizing fundamental mechanisms and translational potential. We first outline the discovery, biological features, synthesis, and purification of circRNAs. Next, their delivery systems, biological functions, and applications are reviewed. Finally, we discuss challenges and future prospects for clinical translation, with a focus on advancing precision medicine, gene therapy, and personalized vaccines. This review uniquely integrates recent advances in circRNA biology with their translational applications, offering a comprehensive perspective from molecular mechanisms to clinical potential.</div></div>\",\"PeriodicalId\":101012,\"journal\":{\"name\":\"Pharmaceutical Science Advances\",\"volume\":\"3 \",\"pages\":\"Article 100085\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-07-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Pharmaceutical Science Advances\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2773216925000236\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pharmaceutical Science Advances","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2773216925000236","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Circular RNA: From non-coding regulators to functional protein encoders
Circular RNAs (circRNAs), a distinct class of non-coding RNAs characterized by a covalently closed circular structure, have gained prominence as a promising research field due to their unique biological properties and functional roles relative to linear RNAs. This review summarizes recent progress in circRNA research, emphasizing fundamental mechanisms and translational potential. We first outline the discovery, biological features, synthesis, and purification of circRNAs. Next, their delivery systems, biological functions, and applications are reviewed. Finally, we discuss challenges and future prospects for clinical translation, with a focus on advancing precision medicine, gene therapy, and personalized vaccines. This review uniquely integrates recent advances in circRNA biology with their translational applications, offering a comprehensive perspective from molecular mechanisms to clinical potential.
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