关于世卫组织四大重点真菌病原体的四十年全球研究：进展与展望

IF 4 3区医学 Q1 INFECTIOUS DISEASES

Journal of Infection and Public Health Pub Date : 2025-08-29 DOI:10.1016/j.jiph.2025.102947

Caixia Tan , Anhua Wu , Chunhui Li

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引用次数: 0

摘要

背景：2022年10月25日，世界卫生组织（WHO）发布了第一份真菌优先病原体清单（FPPL），将新型隐球菌（C. neoformans）、耳念珠菌（C. auris）、烟曲霉（A. fumigatus）和白色念珠菌（C. albicans）分类为“关键优先”病原体，因为它们具有重大的临床影响和不断增加的抗真菌耐药性。虽然文献计量学分析已经对单个真菌病原体进行了分析，但仍然缺乏对所有四种关键病原体的全面和比较评估。为了解决这一差距，我们进行了综合文献计量分析，分析了与这些病原体相关的全球研究趋势和出版物特征，旨在提高全球对这一重要问题的认识并支持未来的准备工作。方法对Web of Science Core Collection （WoSCC）数据库进行全面检索，重点检索1983 - 2023年间发表的英文综述和研究文章。搜索条件包括病原体的名称和他们的医学主题标题（MeSH）的标题。使用Microsoft Excel、VOSviewer、CiteSpace和RStudio中的Bibliometrix-Biblioshiny包导出和分析数据，包括完整记录和引用文献。结果共分析文献19,785篇，真菌研究呈上升趋势，以发达国家为主。新兴经济体，尤其是中国和巴西，也显示出越来越大的贡献。主要的研究领域包括囊状形成、氧化应激和临床影响，如脑膜炎。对于金黄色葡萄球菌，研究的重点是多药耐药、感染控制和诊断。烟曲霉的研究强调抗真菌耐药性、毒力和临床结果，而白色念珠菌的研究强调生物膜形成、抗真菌耐药性和宿主免疫相互作用。抗真菌药物耐药性，特别是像金黄色葡萄球菌这样的新兴病原体，仍然是一个关键问题。结论：这一分析表明人们对真菌研究的兴趣日益浓厚，并强调需要更多地关注真菌与宿主的相互作用、环境适应、新发病原体的流行病学以及加强国际合作。

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Forty years of global research on WHO’s four critical priority fungal pathogens: Advances and prospects

Background

On October 25, 2022, the World Health Organization (WHO) released its first Fungal Priority Pathogen List (FPPL), classifying Cryptococcus neoformans (C. neoformans), Candida auris (C. auris), Aspergillus fumigatus (A. fumigatus), and Candida albicans (C. albicans) as “critical priority” pathogens due to their substantial clinical impact and increasing antifungal resistance. Although bibliometric analyses have been conducted for individual fungal pathogens, a comprehensive and comparative assessment of all four critical pathogens remains lacking. To address this gap, we conducted an integrated bibliometric analysis to analyze global research trends and publication characteristics related to these pathogens, aiming to enhance global awareness and support future preparedness efforts on this important issue.

Methods

We conducted a comprehensive search of the Web of Science Core Collection (WoSCC) database, focusing on English-language review and research articles published from 1983 to 2023. Search terms included the pathogens' names and their Medical Subject Headings (MeSH) terms in the title. The data, including full records and cited references, were exported and analyzed using Microsoft Excel, VOSviewer, CiteSpace, and the Bibliometrix-Biblioshiny package in RStudio.

Results

A total of 19,785 publications were analyzed, showing an increasing trend in fungal research, with developed countries leading in output. Emerging economies, notably China and Brazil, also showed increasing contributions. Key research areas for C. neoformans included capsule formation, oxidative stress, and clinical impacts such as meningitis. For C. auris, studies focused on multidrug resistance, infection control, and diagnostics. A. fumigatus research emphasized antifungal resistance, virulence, and clinical outcomes, while C. albicans studies highlighted biofilm formation, antifungal resistance, and host immune interactions. Antifungal resistance, particularly in emerging pathogens like C. auris, remains a critical concern.

Conclusions

This analysis demonstrated a growing interest in fungal research and highlighted the need for more focus on fungus-host interactions, environmental adaptation, epidemiology of emerging pathogens, and enhanced international collaboration.

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来源期刊

Journal of Infection and Public Health PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH -INFECTIOUS DISEASES

CiteScore

13.10

自引率

1.50%

发文量

203

审稿时长

96 days

期刊介绍： The Journal of Infection and Public Health, first official journal of the Saudi Arabian Ministry of National Guard Health Affairs, King Saud Bin Abdulaziz University for Health Sciences and the Saudi Association for Public Health, aims to be the foremost scientific, peer-reviewed journal encompassing infection prevention and control, microbiology, infectious diseases, public health and the application of healthcare epidemiology to the evaluation of health outcomes. The point of view of the journal is that infection and public health are closely intertwined and that advances in one area will have positive consequences on the other. The journal will be useful to all health professionals who are partners in the management of patients with communicable diseases, keeping them up to date. The journal is proud to have an international and diverse editorial board that will assist and facilitate the publication of articles that reflect a global view on infection control and public health, as well as emphasizing our focus on supporting the needs of public health practitioners. It is our aim to improve healthcare by reducing risk of infection and related adverse outcomes by critical review, selection, and dissemination of new and relevant information in the field of infection control, public health and infectious diseases in all healthcare settings and the community.