伦理维度和社会影响:确保CRISPR技术的社会责任。

IF 4.4 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Frontiers in genome editing Pub Date : 2025-08-20 eCollection Date: 2025-01-01 DOI:10.3389/fgeed.2025.1593172
Irfan Biswas
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引用次数: 0

摘要

CRISPR-Cas9是一个突破性的基因组编辑平台,可以以前所未有的速度、准确性和可负担性切割选定的DNA序列。通过对单个向导RNA进行重编程,研究人员现在可以改变基因功能,纠正致病变异,或引入新的性状。早期的工具,如锌指核酸酶和TALENs,可以执行类似的任务,但要复杂得多,成本也高得多。然而,CRISPR的强大力量引发了紧迫的伦理问题:谁来控制它的使用,社会如何防止种系增强、优生选择或有利于富裕国家和患者的不平等获取?一个广为宣传的胚胎编辑案例已经表明,不成熟、不受监管的实验会如何侵蚀公众的信任。因此,这一观点将CRISPR的科学前景与其社会责任结合起来,认为积极主动、全球协调的治理对于释放利益、防止新形式的基因不平等至关重要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Ethical dimensions and societal implications: ensuring the social responsibility of CRISPR technology.

Ethical dimensions and societal implications: ensuring the social responsibility of CRISPR technology.

CRISPR-Cas9 is a breakthrough genome-editing platform that can cut chosen DNA sequences with unprecedented speed, accuracy, and affordability. By reprogramming a single guide RNA, researchers now alter gene function, correct pathogenic variants, or introduce novel traits. Earlier tools such as zinc-finger nucleases and TALENs performed similar tasks but were significantly more complex and costly. Yet CRISPR's very power raises urgent ethical concerns: Who controls its use, and how can society prevent germ-line enhancement, eugenic selection, or unequal access that favors wealthy nations and patients? A well-publicized case of embryo editing already showed how premature, unregulated experiments can erode public trust. This perspective therefore frames CRISPR's scientific promise alongside its social responsibilities, arguing that proactive, globally coordinated governance is essential to unlock benefits while preventing new forms of genetic inequality.

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CiteScore
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