Alica Pavlova, Bozena Kocikova, Katarina Dudasova, Rene Mandelik, Michaela Urda Dolinska, Zuzana Paralicova, Anna Jackova
{"title":"斯洛伐克人类患者、食品和动物产品中戊型肝炎病毒的发生。","authors":"Alica Pavlova, Bozena Kocikova, Katarina Dudasova, Rene Mandelik, Michaela Urda Dolinska, Zuzana Paralicova, Anna Jackova","doi":"10.1111/zph.70012","DOIUrl":null,"url":null,"abstract":"<div>\n \n <p>Hepatitis E virus (HEV) is the only zoonotic pathogen that causes human viral hepatitis. Foodborne transmission of this virus is one of the most important transmission routes. In this study, performed in various hospitals between 2019 and 2024, we detected the HEV RNA in samples of 66 suspected patients in Eastern Slovakia. In total, 36 patients were found positive. Phylogenetic analysis of selected sequences (<i>n</i> = 26) showed that the majority (<i>n</i> = 22) clustered to genotype HEV-3 group 1. There were only four isolates that clustered to HEV-3 group 2. Statistically significant risk factors associated with viral hepatitis E were gender, age, health status and consumption of animal products. We also analysed suspected food products consumed by patients (<i>n</i> = 10) and animal product samples from stores (<i>n</i> = 218). Only 2 out of 55 (3.6%) pork liver samples from the same butchery shop were found positive for the HEV RNA, clustering to HEV-3 group 2. None of the other animal or food products were found to be positive. This report is the first to utilise genetic typing of the HEV from Slovakia in human patients, food and animal products. However, a direct relationship between human HEV infection and food was not found.</p>\n </div>","PeriodicalId":24025,"journal":{"name":"Zoonoses and Public Health","volume":"72 7","pages":"690-695"},"PeriodicalIF":2.3000,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Occurrence of Hepatitis E Virus in Human Patients, Food and Animal Products From Slovakia\",\"authors\":\"Alica Pavlova, Bozena Kocikova, Katarina Dudasova, Rene Mandelik, Michaela Urda Dolinska, Zuzana Paralicova, Anna Jackova\",\"doi\":\"10.1111/zph.70012\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n <p>Hepatitis E virus (HEV) is the only zoonotic pathogen that causes human viral hepatitis. Foodborne transmission of this virus is one of the most important transmission routes. In this study, performed in various hospitals between 2019 and 2024, we detected the HEV RNA in samples of 66 suspected patients in Eastern Slovakia. In total, 36 patients were found positive. Phylogenetic analysis of selected sequences (<i>n</i> = 26) showed that the majority (<i>n</i> = 22) clustered to genotype HEV-3 group 1. There were only four isolates that clustered to HEV-3 group 2. Statistically significant risk factors associated with viral hepatitis E were gender, age, health status and consumption of animal products. We also analysed suspected food products consumed by patients (<i>n</i> = 10) and animal product samples from stores (<i>n</i> = 218). Only 2 out of 55 (3.6%) pork liver samples from the same butchery shop were found positive for the HEV RNA, clustering to HEV-3 group 2. None of the other animal or food products were found to be positive. This report is the first to utilise genetic typing of the HEV from Slovakia in human patients, food and animal products. However, a direct relationship between human HEV infection and food was not found.</p>\\n </div>\",\"PeriodicalId\":24025,\"journal\":{\"name\":\"Zoonoses and Public Health\",\"volume\":\"72 7\",\"pages\":\"690-695\"},\"PeriodicalIF\":2.3000,\"publicationDate\":\"2025-09-04\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Zoonoses and Public Health\",\"FirstCategoryId\":\"97\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1111/zph.70012\",\"RegionNum\":2,\"RegionCategory\":\"农林科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"INFECTIOUS DISEASES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Zoonoses and Public Health","FirstCategoryId":"97","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/zph.70012","RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}
Occurrence of Hepatitis E Virus in Human Patients, Food and Animal Products From Slovakia
Hepatitis E virus (HEV) is the only zoonotic pathogen that causes human viral hepatitis. Foodborne transmission of this virus is one of the most important transmission routes. In this study, performed in various hospitals between 2019 and 2024, we detected the HEV RNA in samples of 66 suspected patients in Eastern Slovakia. In total, 36 patients were found positive. Phylogenetic analysis of selected sequences (n = 26) showed that the majority (n = 22) clustered to genotype HEV-3 group 1. There were only four isolates that clustered to HEV-3 group 2. Statistically significant risk factors associated with viral hepatitis E were gender, age, health status and consumption of animal products. We also analysed suspected food products consumed by patients (n = 10) and animal product samples from stores (n = 218). Only 2 out of 55 (3.6%) pork liver samples from the same butchery shop were found positive for the HEV RNA, clustering to HEV-3 group 2. None of the other animal or food products were found to be positive. This report is the first to utilise genetic typing of the HEV from Slovakia in human patients, food and animal products. However, a direct relationship between human HEV infection and food was not found.
期刊介绍：
Zoonoses and Public Health brings together veterinary and human health researchers and policy-makers by providing a venue for publishing integrated and global approaches to zoonoses and public health. The Editors will consider papers that focus on timely collaborative and multi-disciplinary research in zoonoses and public health. This journal provides rapid publication of original papers, reviews, and potential discussion papers embracing this collaborative spirit. Papers should advance the scientific knowledge of the sources, transmission, prevention and control of zoonoses and be authored by scientists with expertise in areas such as microbiology, virology, parasitology and epidemiology. Articles that incorporate recent data into new methods, applications, or approaches (e.g. statistical modeling) which enhance public health are strongly encouraged.
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