Emmanuel Osei Nkansah, Binbin Xu, Yunzhu Lan, Mohammad Ishraq Zafar
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Positioning nutrigenomics and nutrigenetics within the framework of male infertility exploration
Male infertility, a complex result of genetic, environmental, and lifestyle factors, has gained significant focus in contemporary medical research. The intricate interplay between genetics, nutrition, and male fertility is crucial for understanding the complex mechanisms that underlie male reproductive health. The twenty-first century has seen a paradigm shift in medicine, where holistic personalized medical care is posited to be ideal and effective. In this regard, this narrative review explored how the convergence of dietary habits and genetic predispositions influence male fertility in the context of predictive, preventive, and personalized medicine. This review explored the evolving landscape of genetic insights into male infertility, creating awareness of their possible engagement as genetic predictors for idiopathic male infertility. It also dissects the roles of nutrigenomics and nutrigenetics in shaping preventive male reproductive medicine strategies through distinguishing the influence of dietary components on genetic expression and further elucidating how epigenetic alterations, influenced by dietary components, impact male fertility, potentially imparting transgenerational effects. Furthermore, this review offers potential personalized reproductive remedies in the form of functional and super foods, gut microbiome enhancers, redox homeostasis and proposes personalized nutrition as an intervention with high prospects in the context of improving male fertility.
期刊介绍:
Drawing from a large number of disciplines, Reproductive Toxicology publishes timely, original research on the influence of chemical and physical agents on reproduction. Written by and for obstetricians, pediatricians, embryologists, teratologists, geneticists, toxicologists, andrologists, and others interested in detecting potential reproductive hazards, the journal is a forum for communication among researchers and practitioners. Articles focus on the application of in vitro, animal and clinical research to the practice of clinical medicine.
All aspects of reproduction are within the scope of Reproductive Toxicology, including the formation and maturation of male and female gametes, sexual function, the events surrounding the fusion of gametes and the development of the fertilized ovum, nourishment and transport of the conceptus within the genital tract, implantation, embryogenesis, intrauterine growth, placentation and placental function, parturition, lactation and neonatal survival. Adverse reproductive effects in males will be considered as significant as adverse effects occurring in females. To provide a balanced presentation of approaches, equal emphasis will be given to clinical and animal or in vitro work. Typical end points that will be studied by contributors include infertility, sexual dysfunction, spontaneous abortion, malformations, abnormal histogenesis, stillbirth, intrauterine growth retardation, prematurity, behavioral abnormalities, and perinatal mortality.