α -硫辛酸的抗氧化潜力减轻实验性牙周炎的进展。

IF 4.9 2区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Journal of Nutritional Biochemistry Pub Date : 2025-09-02 DOI:10.1016/j.jnutbio.2025.110087

Priscila Ayumi Kubota , Deiweson Souza-Monteiro , Zuleni Alexandre da Silva , Deborah Ribeiro Frazão , Vinicius Ruan Neves dos Santos , Paulo Fernando Santos Mendes , Jorddy Neves Cruz , Cassiano Kuchenbecker Rösing , Fabrício Mezzomo Collares , Renata Duarte Souza-Rodrigues , Rafael Rodrigues Lima

{"title":"α -硫辛酸的抗氧化潜力减轻实验性牙周炎的进展。","authors":"Priscila Ayumi Kubota , Deiweson Souza-Monteiro , Zuleni Alexandre da Silva , Deborah Ribeiro Frazão , Vinicius Ruan Neves dos Santos , Paulo Fernando Santos Mendes , Jorddy Neves Cruz , Cassiano Kuchenbecker Rösing , Fabrício Mezzomo Collares , Renata Duarte Souza-Rodrigues , Rafael Rodrigues Lima","doi":"10.1016/j.jnutbio.2025.110087","DOIUrl":null,"url":null,"abstract":"<div><div>This study aimed to evaluate the effects of alpha-lipoic acid supplementation, a well-known antioxidant with therapeutic potential, on the progression of experimental periodontitis in rats. Eighteen male Wistar rats were randomly assigned to three groups (<em>n</em>=6 per group): control, periodontitis, and periodontitis treated with alpha-lipoic acid. Periodontitis was induced by placing bandages around the lower first molars for 14 days. During this same period, the treated group received alpha-lipoic acid by gavage at a dose of 100 mg/kg/day and the control and periodontitis groups received distilled water. Biochemical analyses showed a significant increase in reduced glutathione levels in the supplemented group compared to the periodontitis group, although no significant changes were observed in Trolox-equivalent antioxidant capacity. Micro-Computed Tomography analysis revealed preservation of trabecular number and their thickness, along with an increase in tissue volume in the supplemented animals. Histological evaluation showed less alveolar bone damage and a larger collagen area in the group that received alpha-lipoic acid. The findings suggest that alpha-lipoic acid supplementation effectively mitigates damage associated with experimental periodontitis, enhances antioxidant defenses, and improves alveolar bone integrity.</div></div>","PeriodicalId":16618,"journal":{"name":"Journal of Nutritional Biochemistry","volume":"147 ","pages":"Article 110087"},"PeriodicalIF":4.9000,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Antioxidant potential of alpha-lipoic acid in mitigating progression of experimental periodontitis\",\"authors\":\"Priscila Ayumi Kubota , Deiweson Souza-Monteiro , Zuleni Alexandre da Silva , Deborah Ribeiro Frazão , Vinicius Ruan Neves dos Santos , Paulo Fernando Santos Mendes , Jorddy Neves Cruz , Cassiano Kuchenbecker Rösing , Fabrício Mezzomo Collares , Renata Duarte Souza-Rodrigues , Rafael Rodrigues Lima\",\"doi\":\"10.1016/j.jnutbio.2025.110087\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>This study aimed to evaluate the effects of alpha-lipoic acid supplementation, a well-known antioxidant with therapeutic potential, on the progression of experimental periodontitis in rats. Eighteen male Wistar rats were randomly assigned to three groups (<em>n</em>=6 per group): control, periodontitis, and periodontitis treated with alpha-lipoic acid. Periodontitis was induced by placing bandages around the lower first molars for 14 days. During this same period, the treated group received alpha-lipoic acid by gavage at a dose of 100 mg/kg/day and the control and periodontitis groups received distilled water. Biochemical analyses showed a significant increase in reduced glutathione levels in the supplemented group compared to the periodontitis group, although no significant changes were observed in Trolox-equivalent antioxidant capacity. Micro-Computed Tomography analysis revealed preservation of trabecular number and their thickness, along with an increase in tissue volume in the supplemented animals. Histological evaluation showed less alveolar bone damage and a larger collagen area in the group that received alpha-lipoic acid. The findings suggest that alpha-lipoic acid supplementation effectively mitigates damage associated with experimental periodontitis, enhances antioxidant defenses, and improves alveolar bone integrity.</div></div>\",\"PeriodicalId\":16618,\"journal\":{\"name\":\"Journal of Nutritional Biochemistry\",\"volume\":\"147 \",\"pages\":\"Article 110087\"},\"PeriodicalIF\":4.9000,\"publicationDate\":\"2025-09-02\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Nutritional Biochemistry\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0955286325002499\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"BIOCHEMISTRY & MOLECULAR BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Nutritional Biochemistry","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0955286325002499","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}

引用次数: 0

摘要

本研究旨在评估α -硫辛酸补充剂对实验性牙周炎大鼠进展的影响，α -硫辛酸是一种众所周知的具有治疗潜力的抗氧化剂。18只雄性Wistar大鼠随机分为三组（每组 = 6只）：对照组、牙周炎组和α -硫辛酸治疗牙周炎组。用绷带包裹下第一磨牙14天诱导牙周炎。同期，治疗组灌胃α -硫辛酸100 mg/kg/d，对照组灌胃生理盐水。生化分析显示，与牙周炎组相比，补充组的还原性谷胱甘肽水平显著增加，尽管在trolox等效抗氧化能力方面没有观察到显著变化。显微计算机断层扫描分析显示，在补充的动物中，小梁的数量和厚度得以保留，组织体积也有所增加。组织学评价显示，α -硫辛酸组牙槽骨损伤较小，胶原区较大。研究结果表明，补充α -硫辛酸可有效减轻实验性牙周炎相关的损伤，增强抗氧化防御，并改善牙槽骨完整性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Antioxidant potential of alpha-lipoic acid in mitigating progression of experimental periodontitis

This study aimed to evaluate the effects of alpha-lipoic acid supplementation, a well-known antioxidant with therapeutic potential, on the progression of experimental periodontitis in rats. Eighteen male Wistar rats were randomly assigned to three groups (n=6 per group): control, periodontitis, and periodontitis treated with alpha-lipoic acid. Periodontitis was induced by placing bandages around the lower first molars for 14 days. During this same period, the treated group received alpha-lipoic acid by gavage at a dose of 100 mg/kg/day and the control and periodontitis groups received distilled water. Biochemical analyses showed a significant increase in reduced glutathione levels in the supplemented group compared to the periodontitis group, although no significant changes were observed in Trolox-equivalent antioxidant capacity. Micro-Computed Tomography analysis revealed preservation of trabecular number and their thickness, along with an increase in tissue volume in the supplemented animals. Histological evaluation showed less alveolar bone damage and a larger collagen area in the group that received alpha-lipoic acid. The findings suggest that alpha-lipoic acid supplementation effectively mitigates damage associated with experimental periodontitis, enhances antioxidant defenses, and improves alveolar bone integrity.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Journal of Nutritional Biochemistry 医学-生化与分子生物学

CiteScore

9.50

自引率

3.60%

发文量

237

审稿时长

68 days

期刊介绍： Devoted to advancements in nutritional sciences, The Journal of Nutritional Biochemistry presents experimental nutrition research as it relates to: biochemistry, molecular biology, toxicology, or physiology. Rigorous reviews by an international editorial board of distinguished scientists ensure publication of the most current and key research being conducted in nutrition at the cellular, animal and human level. In addition to its monthly features of critical reviews and research articles, The Journal of Nutritional Biochemistry also periodically publishes emerging issues, experimental methods, and other types of articles.