Miao Lu, Yanan Zhang, Yang Zhang, Xulei Yuan, Tingwei Zhang, Jinlin Song
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Postmenopausal osteoporosis increases periodontal inflammation and the pathogenicity of the oral microbiota in a rat model.
Objectives: This study aims to explore the mechanisms of the detrimental effects of postmenopausal osteoporosis (PMO) on periodontitis.
Methods: An ovariectomized (OVX) rat model was established to investigate the effects of PMO on alveolar bone homeostasis and periodontal inflammation. Chlorhexidine digluconate (CHX) was administered to rats with OVX - periodontitis to ascertain the involvement of the oral microbiota in the influence of PMO on periodontitis. Finally, oral microbiota transplantation was conducted to examine the oral microbiota's pathogenicity.
Results: OVX rats exhibited increased periodontal trabecular bone resorption and inflammation. In addition, depletion of the oral microbiota by CHX decreased the alveolar bone destruction in OVX - periodontitis rats. Furthermore, 16S rRNA gene sequencing demonstrated that PMO changes the composition of the oral microbiota. Finally, oral microbiota transplantation indicated that PMO enhanced the oral microbiota's pathogenicity.
Conclusion: PMO detrimentally affects periodontitis by increasing periodontal inflammation and the pathogenicity of the oral microbiota, which provides a mechanistic understanding of how PMO affects periodontitis and highlights the necessity of more regular monitoring of the oral microbiota in PMO patients.
期刊介绍：
As the first Open Access journal in its field, the Journal of Oral Microbiology aims to be an influential source of knowledge on the aetiological agents behind oral infectious diseases. The journal is an international forum for original research on all aspects of ''oral health''. Articles which seek to understand ''oral health'' through exploration of the pathogenesis, virulence, host-parasite interactions, and immunology of oral infections are of particular interest. However, the journal also welcomes work that addresses the global agenda of oral infectious diseases and articles that present new strategies for treatment and prevention or improvements to existing strategies.
Topics: ''oral health'', microbiome, genomics, host-pathogen interactions, oral infections, aetiologic agents, pathogenesis, molecular microbiology systemic diseases, ecology/environmental microbiology, treatment, diagnostics, epidemiology, basic oral microbiology, and taxonomy/systematics.
Article types: original articles, notes, review articles, mini-reviews and commentaries
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