ABCA1和ABCG1基因的DNA甲基化与中风风险有关。

IF 1.5 3区医学 Q3 CLINICAL NEUROLOGY

Cerebrovascular Diseases Pub Date : 2025-09-04 DOI:10.1159/000548066

Chan Yang, Li Chen, Juan Li, Xiaowei Liu, Xiaoxia Li, Yuhong Zhang, Yi Zhao

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引用次数: 0

摘要

在中国，中风是主要的死亡原因之一。表观遗传因素，特别是与胆固醇调节有关的ABCA1/G1基因的甲基化，正在被研究以了解它们与中风的关系。方法：在这项巢式病例对照研究中，我们检查了来自中国西北队列（CNC-NX）初始阶段的数据，包括53对脑卒中患者和对照组。所有参与者均为年龄≥18岁的成年人。我们检查了条件逻辑回归模型，以确定卒中发生的风险比（OR）和95%置信区间（95% CI）。结果：ABCA1中CpG_10.11.12.13甲基化水平与卒中风险相关（OR 0.93, 95% CI: 0.87-0.99）， ABCG1中CpG_19.20甲基化水平的动态变化与卒中风险相关（OR 1.62, 95% CI: 1.11-2.37）。在动态甲基化中，与低甲基化水平相比，ABCG1中CpG_19.20的高甲基化水平与中风风险高5.10倍相关（OR 5.10, 95% CI: 1.60-16.30）。结论：在中国西北农村人群中，ABCA1和ABCG1基因的低甲基化状态与卒中发病率密切相关。ABCG1中CpG_19.20甲基化水平变化与卒中风险的显著相关性

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DNA methylation of the ABCA1 and ABCG1 genes contribute to stroke risk.

Introduction: Stroke is a major cause of death in China. The epigenetic factors, especially the methylation of ABCA1/G1 genes implicated in cholesterol regulation, are being examined to comprehend their association with stroke.

Methods: In this nested case-control study, we examined data from the North-west China Cohort (CNC-NX) initial phase, involving 53 pairs of stroke cases and controls. All participants were adults aged ≥18 years. We examined the conditional logistic regression models were used to determine the risk ratio (OR) and 95% confidence interval (95% CI) for stroke occurrence.

Results: CpG_10.11.12.13 methylation levels in ABCA1 were associated with stroke risk (OR 0.93, 95% CI: 0.87-0.99), and dynamic changes in CpG_19.20 methylation levels in ABCG1 were associated with stroke risk (OR 1.62, 95% CI: 1.11-2.37). In dynamic methylation, high methylation levels of CpG_19.20 in ABCG1 were associated with a 5.10 times higher risk of stroke compared to low methylation levels (OR 5.10, 95% CI: 1.60-16.30).

Conclusions: In a rural population in North-West China, the hypomethylation status of ABCA1 and ABCG1 genes was strongly associated with the incidence of stroke. Significant correlations between CpG_19.20 methylation levels change in ABCG1 and stroke risk.

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来源期刊

Cerebrovascular Diseases 医学-临床神经学

CiteScore

4.50

自引率

0.00%

发文量

审稿时长

1 months

期刊介绍： A rapidly-growing field, stroke and cerebrovascular research is unique in that it involves a variety of specialties such as neurology, internal medicine, surgery, radiology, epidemiology, cardiology, hematology, psychology and rehabilitation. ''Cerebrovascular Diseases'' is an international forum which meets the growing need for sophisticated, up-to-date scientific information on clinical data, diagnostic testing, and therapeutic issues, dealing with all aspects of stroke and cerebrovascular diseases. It contains original contributions, reviews of selected topics and clinical investigative studies, recent meeting reports and work-in-progress as well as discussions on controversial issues. All aspects related to clinical advances are considered, while purely experimental work appears if directly relevant to clinical issues.