Yuhao Yu, Jiayan Luo, Haizhong Jiang, Haojun Song, Bujiang Wang
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Metal ions and colorectal cancer: unlocking the secrets of tumour cell death.
Background: Colorectal cancer (CRC) is a highly prevalent and fatal malignancy worldwide. Despite advancements in early screening techniques and treatments, the prognosis for patients remains suboptimal. Studies have shown that metal ions play crucial roles in the occurrence, progression, and treatment of CRC.
Method: Regulating the concentrations of specific metal ions within tumour cells can promote cancer cell death and increase the effectiveness of chemotherapy, radiotherapy, targeted therapy, and immunotherapy.
Results: This article reviews the relationships between metal ions such as iron, copper, potassium, calcium, magnesium, and zinc and CRC, summarising recent research progress from mechanistic studies to clinical applications. Magnesium ions inhibit CRC development and metastasis by regulating various signalling pathways can either promote or inhibit tumour-associated gene expression.
Conclusion: Therefore, modulating the concentrations of relevant metal ions within tumour cells could be a potential therapeutic direction for CRC, providing new theoretical foundations and strategies for clinical treatment.
期刊介绍:
Archives of Physiology and Biochemistry: The Journal of Metabolic Diseases is an international peer-reviewed journal which has been relaunched to meet the increasing demand for integrated publication on molecular, biochemical and cellular aspects of metabolic diseases, as well as clinical and therapeutic strategies for their treatment. It publishes full-length original articles, rapid papers, reviews and mini-reviews on selected topics. It is the overall goal of the journal to disseminate novel approaches to an improved understanding of major metabolic disorders.
The scope encompasses all topics related to the molecular and cellular pathophysiology of metabolic diseases like obesity, type 2 diabetes and the metabolic syndrome, and their associated complications.
Clinical studies are considered as an integral part of the Journal and should be related to one of the following topics:
-Dysregulation of hormone receptors and signal transduction
-Contribution of gene variants and gene regulatory processes
-Impairment of intermediary metabolism at the cellular level
-Secretion and metabolism of peptides and other factors that mediate cellular crosstalk
-Therapeutic strategies for managing metabolic diseases
Special issues dedicated to topics in the field will be published regularly.