氧化平衡评分与妊娠期糖尿病风险的关系:一项病例对照研究。

IF 3.3 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM
Fatemeh Maleki Sedgi, Amir Hossein Hassani, Amir Hossein Faghfouri, Shahsanam Gheibi, Yousef Mohammadpour, Amin Mokari-Yamchi
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引用次数: 0

摘要

背景:妊娠期糖尿病(GDM)是一种常见的妊娠并发症,与氧化应激升高密切相关。氧化平衡评分(OBS)综合了影响氧化应激的饮食和生活方式因素,但其与GDM的关系尚不清楚。方法:在本病例对照研究中,从伊朗乌尔米娅的初级卫生保健中心招募了150名GDM孕妇和170名健康对照者。研究人员使用经过验证的168项食物频率问卷(FFQ)评估膳食摄入量,并根据饮食和生活方式的促氧化剂和抗氧化剂成分计算OBS。Logistic回归模型用于检验OBS分位数与GDM风险之间的关系,并对潜在的混杂因素进行调整。结果:与对照组相比,GDM患者的总OBS(18.37±8.77比20.64±10.98,p = 0.041)和膳食OBS(16.1±6.46比17.89±8.66,p = 0.036)显著降低。关键抗氧化营养素的摄入量,包括核黄素、叶酸、镁和锌,在GDM组显著降低(p结论:较高的OBS,特别是在其饮食和生活方式组成部分,与GDM的风险降低有关。这些发现强调了富含抗氧化剂的饮食和改变生活方式对预防GDM的重要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Association between oxidative balance score and gestational diabetes mellitus risk: a case-control study.

Background: Gestational diabetes mellitus (GDM) is a common pregnancy complication closely associated with increased oxidative stress. The Oxidative Balance Score (OBS) integrates dietary and lifestyle factors influencing oxidative stress, yet its relationship with GDM remains unclear.

Methods: In this case-control study, 150 pregnant women with GDM and 170 healthy controls were recruited from primary healthcare centers in Urmia, Iran. Dietary intake was assessed using a validated 168-item Food Frequency Questionnaire (FFQ), and OBS was calculated based on dietary and lifestyle pro-oxidant and antioxidant components. Logistic regression models were used to examine the association between OBS tertiles and GDM risk, adjusting for potential confounders.

Results: Women with GDM had significantly lower total OBS (18.37 ± 8.77 vs. 20.64 ± 10.98, p = 0.041) and dietary OBS (16.1 ± 6.46 vs. 17.89 ± 8.66, p = 0.036) compared to controls. key antioxidant nutrient intake, including riboflavin, folate, magnesium, and zinc, were significantly lower in the GDM group (p < 0.05). In contrast, lifestyle OBS was significantly higher in the GDM group (4.05 ± 1.4 vs. 3.65 ± 1.62, p = 0.018). Women in the highest OBS tertile had a 23% lower risk of GDM (aOR = 0.77; 95% CI: 0.48-0.92). Higher dietary and lifestyle OBS were also inversely associated with GDM risk.

Conclusion: A higher OBS, particularly in its dietary and lifestyle components, is associated with a reduced risk of GDM. These findings highlight the importance of antioxidant-rich diets and lifestyle modifications in GDM prevention.

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来源期刊
BMC Endocrine Disorders
BMC Endocrine Disorders ENDOCRINOLOGY & METABOLISM-
CiteScore
4.40
自引率
0.00%
发文量
280
审稿时长
>12 weeks
期刊介绍: BMC Endocrine Disorders is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of endocrine disorders, as well as related molecular genetics, pathophysiology, and epidemiology.
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