Fatemeh Maleki Sedgi, Amir Hossein Hassani, Amir Hossein Faghfouri, Shahsanam Gheibi, Yousef Mohammadpour, Amin Mokari-Yamchi
{"title":"氧化平衡评分与妊娠期糖尿病风险的关系:一项病例对照研究。","authors":"Fatemeh Maleki Sedgi, Amir Hossein Hassani, Amir Hossein Faghfouri, Shahsanam Gheibi, Yousef Mohammadpour, Amin Mokari-Yamchi","doi":"10.1186/s12902-025-02028-6","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Gestational diabetes mellitus (GDM) is a common pregnancy complication closely associated with increased oxidative stress. The Oxidative Balance Score (OBS) integrates dietary and lifestyle factors influencing oxidative stress, yet its relationship with GDM remains unclear.</p><p><strong>Methods: </strong>In this case-control study, 150 pregnant women with GDM and 170 healthy controls were recruited from primary healthcare centers in Urmia, Iran. Dietary intake was assessed using a validated 168-item Food Frequency Questionnaire (FFQ), and OBS was calculated based on dietary and lifestyle pro-oxidant and antioxidant components. Logistic regression models were used to examine the association between OBS tertiles and GDM risk, adjusting for potential confounders.</p><p><strong>Results: </strong>Women with GDM had significantly lower total OBS (18.37 ± 8.77 vs. 20.64 ± 10.98, p = 0.041) and dietary OBS (16.1 ± 6.46 vs. 17.89 ± 8.66, p = 0.036) compared to controls. key antioxidant nutrient intake, including riboflavin, folate, magnesium, and zinc, were significantly lower in the GDM group (p < 0.05). In contrast, lifestyle OBS was significantly higher in the GDM group (4.05 ± 1.4 vs. 3.65 ± 1.62, p = 0.018). Women in the highest OBS tertile had a 23% lower risk of GDM (aOR = 0.77; 95% CI: 0.48-0.92). Higher dietary and lifestyle OBS were also inversely associated with GDM risk.</p><p><strong>Conclusion: </strong>A higher OBS, particularly in its dietary and lifestyle components, is associated with a reduced risk of GDM. These findings highlight the importance of antioxidant-rich diets and lifestyle modifications in GDM prevention.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":"25 1","pages":"205"},"PeriodicalIF":3.3000,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12409937/pdf/","citationCount":"0","resultStr":"{\"title\":\"Association between oxidative balance score and gestational diabetes mellitus risk: a case-control study.\",\"authors\":\"Fatemeh Maleki Sedgi, Amir Hossein Hassani, Amir Hossein Faghfouri, Shahsanam Gheibi, Yousef Mohammadpour, Amin Mokari-Yamchi\",\"doi\":\"10.1186/s12902-025-02028-6\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Gestational diabetes mellitus (GDM) is a common pregnancy complication closely associated with increased oxidative stress. The Oxidative Balance Score (OBS) integrates dietary and lifestyle factors influencing oxidative stress, yet its relationship with GDM remains unclear.</p><p><strong>Methods: </strong>In this case-control study, 150 pregnant women with GDM and 170 healthy controls were recruited from primary healthcare centers in Urmia, Iran. Dietary intake was assessed using a validated 168-item Food Frequency Questionnaire (FFQ), and OBS was calculated based on dietary and lifestyle pro-oxidant and antioxidant components. Logistic regression models were used to examine the association between OBS tertiles and GDM risk, adjusting for potential confounders.</p><p><strong>Results: </strong>Women with GDM had significantly lower total OBS (18.37 ± 8.77 vs. 20.64 ± 10.98, p = 0.041) and dietary OBS (16.1 ± 6.46 vs. 17.89 ± 8.66, p = 0.036) compared to controls. key antioxidant nutrient intake, including riboflavin, folate, magnesium, and zinc, were significantly lower in the GDM group (p < 0.05). In contrast, lifestyle OBS was significantly higher in the GDM group (4.05 ± 1.4 vs. 3.65 ± 1.62, p = 0.018). Women in the highest OBS tertile had a 23% lower risk of GDM (aOR = 0.77; 95% CI: 0.48-0.92). Higher dietary and lifestyle OBS were also inversely associated with GDM risk.</p><p><strong>Conclusion: </strong>A higher OBS, particularly in its dietary and lifestyle components, is associated with a reduced risk of GDM. These findings highlight the importance of antioxidant-rich diets and lifestyle modifications in GDM prevention.</p>\",\"PeriodicalId\":9152,\"journal\":{\"name\":\"BMC Endocrine Disorders\",\"volume\":\"25 1\",\"pages\":\"205\"},\"PeriodicalIF\":3.3000,\"publicationDate\":\"2025-09-04\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12409937/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"BMC Endocrine Disorders\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1186/s12902-025-02028-6\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"ENDOCRINOLOGY & METABOLISM\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"BMC Endocrine Disorders","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1186/s12902-025-02028-6","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}
Association between oxidative balance score and gestational diabetes mellitus risk: a case-control study.
Background: Gestational diabetes mellitus (GDM) is a common pregnancy complication closely associated with increased oxidative stress. The Oxidative Balance Score (OBS) integrates dietary and lifestyle factors influencing oxidative stress, yet its relationship with GDM remains unclear.
Methods: In this case-control study, 150 pregnant women with GDM and 170 healthy controls were recruited from primary healthcare centers in Urmia, Iran. Dietary intake was assessed using a validated 168-item Food Frequency Questionnaire (FFQ), and OBS was calculated based on dietary and lifestyle pro-oxidant and antioxidant components. Logistic regression models were used to examine the association between OBS tertiles and GDM risk, adjusting for potential confounders.
Results: Women with GDM had significantly lower total OBS (18.37 ± 8.77 vs. 20.64 ± 10.98, p = 0.041) and dietary OBS (16.1 ± 6.46 vs. 17.89 ± 8.66, p = 0.036) compared to controls. key antioxidant nutrient intake, including riboflavin, folate, magnesium, and zinc, were significantly lower in the GDM group (p < 0.05). In contrast, lifestyle OBS was significantly higher in the GDM group (4.05 ± 1.4 vs. 3.65 ± 1.62, p = 0.018). Women in the highest OBS tertile had a 23% lower risk of GDM (aOR = 0.77; 95% CI: 0.48-0.92). Higher dietary and lifestyle OBS were also inversely associated with GDM risk.
Conclusion: A higher OBS, particularly in its dietary and lifestyle components, is associated with a reduced risk of GDM. These findings highlight the importance of antioxidant-rich diets and lifestyle modifications in GDM prevention.
期刊介绍:
BMC Endocrine Disorders is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of endocrine disorders, as well as related molecular genetics, pathophysiology, and epidemiology.