Cross-sectional study on the connection between collateral status and cognitive impairment after stroke based on neural regulation and protein metabolism.

Background: Post-stroke cognitive impairment (PSCI), a common complication following stroke, significantly impacts patients' quality of life and prognosis. Research indicates that neuroregulation and protein metabolic disorders play crucial roles in the development of PSCI.

Purpose: This study aimed to evaluate the reliability of the Regional Meningoarterial Score (rLMC) in determining collateral circulation status in acute ischaemic stroke patients.

Method: Participants were selected based on specific criteria including MRI-detected recent cerebral infarction, absence of prior large-scale subcortical infarction or haemorrhage, and no history of Alzheimer's disease or cognitive impairment.

Results: The results showed that cognitive impairment group (CI group) exhibited significantly lower serum acetylcholine levels compared to normal control group (CN group), while β-amyloid protein levels were markedly higher. CI group also demonstrated reduced expression of neuroregulatory factors.

Conclusion: These findings demonstrate that neuroregulatory factors and protein metabolites can serve as potential biomarkers for early diagnosis and intervention, effectively predicting post-stroke cognitive impairment.