为慢性肝病的液-液相分离研究提供新的思路。

IF 7.5 2区医学 Q1 PHARMACOLOGY & PHARMACY

Drug Discovery Today Pub Date : 2025-09-02 DOI:10.1016/j.drudis.2025.104464

Ming-Hui Li , Yang Yang , Qi-Qi Dong , Wen-Jie Sun , Hui Tao , Jing-Jing Yang

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引用次数: 0

摘要

液-液相分离（LLPS）是细胞内生物大分子弱多价相互作用形成无膜结构的一种现象，近年来在慢性肝病的研究中受到广泛关注。LLPS在慢性肝病的发生发展中具有多种作用，包括调节病毒复制、影响脂质代谢、调节免疫反应、参与基因表达调控等。本文综述了LLPS在慢性肝病中的具体机制，并探讨了其在药物开发、免疫治疗、基因治疗等方面的潜在应用，为慢性肝病的治疗提供新的思路。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Shining light on liquid–liquid phase separation in chronic liver disease

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Shining light on liquid–liquid phase separation in chronic liver disease

Liquid–liquid phase separation (LLPS), a phenomenon characterized by a membrane-free structure formed by weak multivalent interactions of intracellular biological macromolecules, has attracted wide attention in the study of chronic liver diseases in recent years. LLPS has multiple roles in the occurrence and development of chronic liver disease, including regulating virus replication, affecting lipid metabolism, regulating immune response, and participating in the regulation of gene expression. This article reviews the specific mechanism of LLPS in chronic liver disease, and discusses its potential application in drug development, immunotherapy, and gene therapy, providing new ideas for the treatment of chronic liver disease.

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来源期刊

Drug Discovery Today 医学-药学

CiteScore

14.80

自引率

2.70%

发文量

293

审稿时长

6 months

期刊介绍： Drug Discovery Today delivers informed and highly current reviews for the discovery community. The magazine addresses not only the rapid scientific developments in drug discovery associated technologies but also the management, commercial and regulatory issues that increasingly play a part in how R&D is planned, structured and executed. Features include comment by international experts, news and analysis of important developments, reviews of key scientific and strategic issues, overviews of recent progress in specific therapeutic areas and conference reports.