功能丧失突变确保对免疫检查点治疗的反应被NOD2拒绝

IF 16.3 1区医学 Q1 IMMUNOLOGY

Science Immunology Pub Date : 2025-09-05 DOI:10.1126/sciimmunol.aeb8333

Ana C. Anderson, Manu Rangachari

引用次数: 0

摘要

NOD2的功能缺失突变可能预测癌症患者对PD-1阻断单药治疗的阳性反应。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Loss-of-function mutations ensure that response to immune checkpoint therapy is NOD2 be denied

Loss-of-function mutations in NOD2 may predict positive response to PD-1 blockade monotherapy in cancer.

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来源期刊

Science Immunology Immunology and Microbiology-Immunology

CiteScore

32.90

自引率

2.00%

发文量

183

期刊介绍： Science Immunology is a peer-reviewed journal that publishes original research articles in the field of immunology. The journal encourages the submission of research findings from all areas of immunology, including studies on innate and adaptive immunity, immune cell development and differentiation, immunogenomics, systems immunology, structural immunology, antigen presentation, immunometabolism, and mucosal immunology. Additionally, the journal covers research on immune contributions to health and disease, such as host defense, inflammation, cancer immunology, autoimmunity, allergy, transplantation, and immunodeficiency. Science Immunology maintains the same high-quality standard as other journals in the Science family and aims to facilitate understanding of the immune system by showcasing innovative advances in immunology research from all organisms and model systems, including humans.