这里越来越热了：用口服HO-1抑制剂加热肿瘤微环境

IF 16.3 1区医学 Q1 IMMUNOLOGY

Science Immunology Pub Date : 2025-09-05 DOI:10.1126/sciimmunol.aeb8328

Cait A. McAlindon, Rachael A. Clark

引用次数: 0

摘要

一种新的口服生物可利用的HO-1抑制剂通过增强CD8 T细胞的募集来增强小鼠化疗后的肿瘤清除。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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It’s getting hot in here: Heating up the tumor microenvironment with an oral HO-1 inhibitor

A new orally bioavailable HO-1 inhibitor enhances tumor clearance after chemotherapy in mice by enhancing the recruitment of CD8 T cells.

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来源期刊

Science Immunology Immunology and Microbiology-Immunology

CiteScore

32.90

自引率

2.00%

发文量

183

期刊介绍： Science Immunology is a peer-reviewed journal that publishes original research articles in the field of immunology. The journal encourages the submission of research findings from all areas of immunology, including studies on innate and adaptive immunity, immune cell development and differentiation, immunogenomics, systems immunology, structural immunology, antigen presentation, immunometabolism, and mucosal immunology. Additionally, the journal covers research on immune contributions to health and disease, such as host defense, inflammation, cancer immunology, autoimmunity, allergy, transplantation, and immunodeficiency. Science Immunology maintains the same high-quality standard as other journals in the Science family and aims to facilitate understanding of the immune system by showcasing innovative advances in immunology research from all organisms and model systems, including humans.