通过基线校正克服SiPM噪声,提高TOF-PET快速集成电路的CTR

IF 3.5 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Afonso Silvério Xavier De Matos Pinto;Nicolaus Kratochwil;Sergio Gómez;David Gascón;Pedro Correia;João Veloso;Emilie Roncali;Ana Luísa Silva;Gerard Ariño-Estrada
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引用次数: 0

摘要

由于闪烁材料、光电探测器和读出电子技术的进步,飞行时间正电子发射断层扫描(TOF-PET)的时间分辨率在过去十年中有了显著提高,与传统的正电子发射断层扫描相比,这增加了信噪比(SNR)。TOF-PET探测器中的硅光电倍增管通常工作在高偏置电压下,以增加信号噪声为代价来提高时间性能。SiPM噪声,无论是相关的还是不相关的,都可能导致基线波动,在使用前沿触发策略时导致时间行走效应,从而限制定时性能。我们使用FastIC ASIC检查了SiPM基线波动的影响,FastIC ASIC是一种可扩展的多通道读出器,用于快速定时应用。我们通过在实际闪烁事件之前使用由暗计数触发的比较器信号来标记噪声事件。我们用闪烁晶体和切伦科夫辐射体测试了不同的分类和校正方法,并耦合了来自Broadcom (NUV-MT)和Hamamatsu Photonics的模拟sipm。我们通过修正噪声事件的时间漫步,将锗酸铋2\ × 2\ × 3 mm3 (BGO)晶体的符合时间分辨率(CTR)从$410~\pm ~10$降低到$388~\pm ~10$ ps FWHM(5%)。通过过滤噪声事件,我们测量到LYSO晶体从$107~\pm 2$到$93.5~\pm ~0.6$ ps(11%)。通过滤波噪声事件,EJ232塑料闪烁体的CTR也提高了9%,从82.2~ 0.5美元降低到75~ 1美元。本研究提出了一种可扩展的方法,用于在全TOF-PET系统中标记不希望发生的事件,并讨论了SiPM噪声对fasttic读出的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Improving CTR With the FastIC ASIC for TOF-PET by Overcoming SiPM Noise With Baseline Correction
Time resolution in time-of-flight positron emission tomography (TOF-PET) has improved significantly over the last decade due to advancements in scintillation materials, photodetectors, and readout electronics, which has increased the signal-to-noise ratio (SNR) compared to conventional positron emission tomography. Silicon photomultipliers (SiPMs) in TOF-PET detectors are often operated at high bias voltage to improve the time performance at the expense of increasing signal noise. SiPM noise, both correlated and uncorrelated, can cause baseline fluctuations, leading to time-walk effects when a leading edge trigger strategy is used, and thus limiting timing performance. We examined the effect of SiPM baseline fluctuations using the FastIC ASIC, a scalable multichannel readout for fast timing applications. We flagged noisy events by using a comparator signal triggered by dark counts before the actual scintillation event. We tested different classification and correction methods with scintillating crystals and Cherenkov radiators, coupled to analog SiPMs from Broadcom (NUV-MT) and Hamamatsu Photonics. We reduced the coincidence time resolution (CTR) in bismuth germanate $2\times 2\times $ 3 mm3 (BGO) crystals from $410~\pm ~10$ to $388~\pm ~10$ ps FWHM (5%) by correcting the time-walk on the noisy events. We measured an improvement from $107~\pm 2$ to $93.5~\pm ~0.6$ ps (11%) for LYSO $2\times 2\times $ 3 mm3 crystals by filtering the noisy events. An improvement of 9% on the CTR of the EJ232 plastic scintillator was also achieved by filtering noisy events, reducing it from $82.2~\pm ~0.5$ to $75~\pm ~1$ ps. This study presents a scalable method for flagging undesired events in a full TOF-PET system and discusses the impact of SiPM noise on the FastIC readout.
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来源期刊
IEEE Transactions on Radiation and Plasma Medical Sciences
IEEE Transactions on Radiation and Plasma Medical Sciences RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-
CiteScore
8.00
自引率
18.20%
发文量
109
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